A0A922HG47 · A0A922HG47_DERFA
- ProteinHedgehog protein
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids582 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
function
The C-terminal part of the hedgehog protein precursor displays an autoproteolysis activity that results in the cleavage of the full-length protein into two parts (N-product and C-product). In addition, the C-terminal part displays a cholesterol transferase activity that results by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated N-product. Once cleaved, the C-product has no signaling activity and diffuses from the cell.
Protein hedgehog N-product
The dually lipidated hedgehog protein N-product is a morphogen which is essential for a variety of patterning events during development.
Protein hedgehog
The C-terminal part of the hedgehog protein precursor displays an autoproteolysis activity that results in the cleavage of the full-length protein into two parts (N-product and C-product). In addition, the C-terminal part displays a cholesterol transferase activity that results by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated N-product.
Catalytic activity
- glycyl-L-cysteinyl-[protein] + cholesterol + H+ = [protein]-C-terminal glycyl cholesterol ester + N-terminal L-cysteinyl-[protein]This reaction proceeds in the forward direction.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | endoplasmic reticulum membrane | |
Cellular Component | extracellular space | |
Cellular Component | Golgi membrane | |
Cellular Component | plasma membrane | |
Molecular Function | calcium ion binding | |
Molecular Function | morphogen activity | |
Molecular Function | patched binding | |
Molecular Function | peptidase activity | |
Molecular Function | transferase activity | |
Biological Process | anatomical structure morphogenesis | |
Biological Process | cell fate specification | |
Biological Process | cell-cell signaling | |
Biological Process | intein-mediated protein splicing | |
Biological Process | protein autoprocessing | |
Biological Process | regulation of gene expression | |
Biological Process | segment polarity determination | |
Biological Process | smoothened signaling pathway | |
Biological Process | system development |
Keywords
- Molecular function
- Ligand
Names & Taxonomy
Protein names
- Recommended nameHedgehog protein
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Arthropoda > Chelicerata > Arachnida > Acari > Acariformes > Sarcoptiformes > Astigmata > Psoroptidia > Analgoidea > Pyroglyphidae > Dermatophagoidinae > Dermatophagoides
Accessions
- Primary accessionA0A922HG47
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Sonic hedgehog protein
Protein hedgehog N-product
Cell membrane ; Lipid-anchor
Keywords
- Cellular component
PTM/Processing
Keywords
- PTM
Interaction
Subunit
Interacts with shf.
Structure
Family & Domains
Features
Showing features for region, compositional bias, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 104-138 | Disordered | ||||
Sequence: QKSNQHQLNSHHHHHQNHHRPYHHRSRSSSSSSTI | ||||||
Compositional bias | 110-129 | Basic residues | ||||
Sequence: QLNSHHHHHQNHHRPYHHRS | ||||||
Domain | 339-444 | Hint | ||||
Sequence: GGCFDQNSTVIGHNGQTINIDNLRIGDEILTMNPATGHLEYSSIIMFLDRNPSIERLYYEIETEFGRMITATPSHLLFISDTGNIDDKHEEFVSKIEMNQYLFVVM | ||||||
Domain | 460-504 | Hint | ||||
Sequence: ETTPRLERIIRISTKKSKGIYAPLTVTGTIVVNNIVASCYAIINS |
Sequence similarities
Belongs to the hedgehog family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length582
- Mass (Da)67,344
- Last updated2023-02-22 v1
- ChecksumF9075C0B806ABE5B
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 110-129 | Basic residues | ||||
Sequence: QLNSHHHHHQNHHRPYHHRS |
Keywords
- Technical term