A0A922HG47 · A0A922HG47_DERFA

Function

function

The C-terminal part of the hedgehog protein precursor displays an autoproteolysis activity that results in the cleavage of the full-length protein into two parts (N-product and C-product). In addition, the C-terminal part displays a cholesterol transferase activity that results by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated N-product. Once cleaved, the C-product has no signaling activity and diffuses from the cell.

Protein hedgehog N-product

The dually lipidated hedgehog protein N-product is a morphogen which is essential for a variety of patterning events during development.

Protein hedgehog

The C-terminal part of the hedgehog protein precursor displays an autoproteolysis activity that results in the cleavage of the full-length protein into two parts (N-product and C-product). In addition, the C-terminal part displays a cholesterol transferase activity that results by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated N-product.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

GO annotations

AspectTerm
Cellular Componentendoplasmic reticulum membrane
Cellular Componentextracellular space
Cellular ComponentGolgi membrane
Cellular Componentplasma membrane
Molecular Functioncalcium ion binding
Molecular Functionmorphogen activity
Molecular Functionpatched binding
Molecular Functionpeptidase activity
Molecular Functiontransferase activity
Biological Processanatomical structure morphogenesis
Biological Processcell fate specification
Biological Processcell-cell signaling
Biological Processintein-mediated protein splicing
Biological Processprotein autoprocessing
Biological Processregulation of gene expression
Biological Processsegment polarity determination
Biological Processsmoothened signaling pathway
Biological Processsystem development

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Hedgehog protein

Gene names

    • ORF names
      DERF_016016

Organism names

  • Taxonomic identifier
  • Strain
    • Derf
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Arthropoda > Chelicerata > Arachnida > Acari > Acariformes > Sarcoptiformes > Astigmata > Psoroptidia > Analgoidea > Pyroglyphidae > Dermatophagoidinae > Dermatophagoides

Accessions

  • Primary accession
    A0A922HG47

Proteomes

Subcellular Location

Sonic hedgehog protein

Endoplasmic reticulum membrane
Golgi apparatus membrane

Protein hedgehog N-product

Cell membrane
; Lipid-anchor

Keywords

PTM/Processing

Keywords

Interaction

Subunit

Interacts with shf.

Family & Domains

Features

Showing features for region, compositional bias, domain.

TypeIDPosition(s)Description
Region104-138Disordered
Compositional bias110-129Basic residues
Domain339-444Hint
Domain460-504Hint

Sequence similarities

Belongs to the hedgehog family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    582
  • Mass (Da)
    67,344
  • Last updated
    2023-02-22 v1
  • Checksum
    F9075C0B806ABE5B
MTNNDNIAINDHYHDQQIWQKSSNFINNNQNHHHHHHNNNDNQCNRSIIMIDNETNHQYNKLNEIRTKSNDIIINVRLKMIDTLKFIIWLLPLSFMFEMKRSQQKSNQHQLNSHHHHHQNHHRPYHHRSRSSSSSSTISIIDHQQQLMSIIIIIMLIIQQSQLTMSCGPGRGGSRRRSPRKLIPLVFKQHVPNVSENTLGASGLNEGPITRNHRRFKELVPNYNQDILFKDEEGTGADRLMTQRLKEKLNTLAISVMNQWPGVRLRVTEGWDEDGSHASNSLHYEGRAVDITTSDRDRSKYGMLARLAVEAGFDWVYYESRFHIHCSVKSEKSESARNGGCFDQNSTVIGHNGQTINIDNLRIGDEILTMNPATGHLEYSSIIMFLDRNPSIERLYYEIETEFGRMITATPSHLLFISDTGNIDDKHEEFVSKIEMNQYLFVVMNQSDNQNKSVAAAVAETTPRLERIIRISTKKSKGIYAPLTVTGTIVVNNIVASCYAIINSQQLSHLSFIPIRWLYQFIKFGDYLSQQLHVHHSQLIIRTTKQSDQSPSPSSLPIGIHWYPRLLYTMFNYFIPNDYIYQ

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias110-129Basic residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
ASGP02000009
EMBL· GenBank· DDBJ
KAH9491287.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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