A0A919EFJ6 · A0A919EFJ6_9ACTN
- ProteinImidazole glycerol phosphate synthase subunit HisH
- GenehisH
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids206 (go to sequence)
- Protein existencePredicted
- Annotation score3/5
Function
function
IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.
Catalytic activity
- 5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + L-glutamine = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate + H+ + L-glutamate
Pathway
Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 5/9.
Features
Showing features for active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Active site | 77 | Nucleophile | ||||
Sequence: C | ||||||
Active site | 187 | |||||
Sequence: H | ||||||
Active site | 189 | |||||
Sequence: E |
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | hydrolase activity | |
Molecular Function | lyase activity | |
Molecular Function | pentosyltransferase activity | |
Biological Process | glutamine metabolic process | |
Biological Process | L-histidine biosynthetic process |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameImidazole glycerol phosphate synthase subunit HisH
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Actinomycetota > Actinomycetes > Kitasatosporales > Streptomycetaceae > Streptomyces
Accessions
- Primary accessionA0A919EFJ6
Proteomes
Interaction
Subunit
Heterodimer of HisH and HisF.
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 2-202 | Glutamine amidotransferase | ||||
Sequence: IFDYGFGNVRSAERALAHVGADVEITRDYDRAMNADGLLVPGVGAFAACMRGLRAARGDWIVGRRLAGGRPVMGICVGMQILFERGIEHGEETEGLDEWPGTVEPLKAPVVPHMGWNTVEPAEGSRLFAGLDAGTRYYFVHSYGVREWNFETGNASLHPPQVTWATHGERFVAAVENGPLCATQFHPEKSGDAGAQLLTNW |
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length206
- Mass (Da)22,425
- Last updated2023-02-22 v1
- Checksum073E4D9BF29D1D8F
Keywords
- Technical term