A0A919EFJ6 · A0A919EFJ6_9ACTN

  • Protein
    Imidazole glycerol phosphate synthase subunit HisH
  • Gene
    hisH
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Predicted
  • Annotation score
    3/5

Function

function

IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Pathway

Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 5/9.

Features

Showing features for active site.

TypeIDPosition(s)Description
Active site77Nucleophile
Active site187
Active site189

GO annotations

AspectTerm
Molecular Functionhydrolase activity
Molecular Functionlyase activity
Molecular Functionpentosyltransferase activity
Biological Processglutamine metabolic process
Biological ProcessL-histidine biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Imidazole glycerol phosphate synthase subunit HisH
  • EC number
  • Alternative names
    • IGP synthase glutaminase subunit
    • IGP synthase subunit HisH
    • ImGP synthase subunit HisH

Gene names

    • Name
      hisH
    • ORF names
      GCM10010218_54380

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • JCM 4059
  • Taxonomic lineage
    Bacteria > Actinomycetota > Actinomycetes > Kitasatosporales > Streptomycetaceae > Streptomyces

Accessions

  • Primary accession
    A0A919EFJ6

Proteomes

Interaction

Subunit

Heterodimer of HisH and HisF.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain2-202Glutamine amidotransferase

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    206
  • Mass (Da)
    22,425
  • Last updated
    2023-02-22 v1
  • Checksum
    073E4D9BF29D1D8F
MIFDYGFGNVRSAERALAHVGADVEITRDYDRAMNADGLLVPGVGAFAACMRGLRAARGDWIVGRRLAGGRPVMGICVGMQILFERGIEHGEETEGLDEWPGTVEPLKAPVVPHMGWNTVEPAEGSRLFAGLDAGTRYYFVHSYGVREWNFETGNASLHPPQVTWATHGERFVAAVENGPLCATQFHPEKSGDAGAQLLTNWIESL

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
BNBD01000015
EMBL· GenBank· DDBJ
GHF66052.1
EMBL· GenBank· DDBJ
Genomic DNA

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Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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