A0A918YYN9 · A0A918YYN9_9GAMM
- ProteinUndecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphate transferase
- GenewecA
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids770 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
function
Catalyzes the transfer of the GlcNAc-1-phosphate moiety from UDP-GlcNAc onto the carrier lipid undecaprenyl phosphate (C55-P), yielding GlcNAc-pyrophosphoryl-undecaprenyl (GlcNAc-PP-C55).
Catalytic activity
- di-trans,octa-cis-undecaprenyl phosphate + UDP-N-acetyl-alpha-D-glucosamine = N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + UMP
Cofactor
Protein has several cofactor binding sites:
Pathway
Bacterial outer membrane biogenesis; LPS O-antigen biosynthesis.
Features
Showing features for binding site.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | Gram-negative-bacterium-type cell wall | |
Cellular Component | plasma membrane | |
Molecular Function | glycosyltransferase activity | |
Molecular Function | isomerase activity | |
Molecular Function | magnesium ion binding | |
Molecular Function | manganese ion binding | |
Molecular Function | UDP-N-acetylglucosamine-undecaprenyl-phosphate N-acetylglucosaminephosphotransferase activity | |
Biological Process | cell wall macromolecule biosynthetic process | |
Biological Process | cell wall organization | |
Biological Process | O antigen biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameUndecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphate transferase
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Gammaproteobacteria > Lysobacterales > Lysobacteraceae > Vulcaniibacterium
Accessions
- Primary accessionA0A918YYN9
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Cell inner membrane ; Multi-pass membrane protein
Cell membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 6-24 | Helical | ||||
Sequence: LEAASAIALAVTLFLIFTV | ||||||
Transmembrane | 45-66 | Helical | ||||
Sequence: GSVPLIGGLCFFLGTVVGLAYA | ||||||
Transmembrane | 72-89 | Helical | ||||
Sequence: TIATLMIPSGLIVMVGVL | ||||||
Transmembrane | 101-119 | Helical | ||||
Sequence: LAVQAAAAVMVIAASGLYL | ||||||
Transmembrane | 131-151 | Helical | ||||
Sequence: FALGALGIPLSVIAVIGLINA | ||||||
Transmembrane | 158-177 | Helical | ||||
Sequence: IDGLAASIAMVAIAAIFLYS | ||||||
Transmembrane | 183-203 | Helical | ||||
Sequence: AMTGVLLLLQVLFAALVPYLC | ||||||
Transmembrane | 215-236 | Helical | ||||
Sequence: FMGDAGSTLIGFLLAWSLIFMS | ||||||
Transmembrane | 294-313 | Helical | ||||
Sequence: MALAVIVAMAVTLVAVGYVL | ||||||
Transmembrane | 319-340 | Helical | ||||
Sequence: LLNLTLFLAVLASYVLLFQTAL |
Keywords
- Cellular component
Structure
Family & Domains
Features
Showing features for region, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 360-379 | Disordered | ||||
Sequence: LAAASGNEPAPPAREPSTPP | ||||||
Domain | 400-739 | UDP-N-acetylglucosamine 2-epimerase | ||||
Sequence: RELEQDGRFDARFCVAAPDPGEQERVLGLFGIRPDARIELPPSAAHGAIDAETMNGMKRLLGEFRPDVVLVPGDSPATLAASLAAFSQRIPIARIESALPDEARGARADAVSRRLSSLLATVNIAPSECRGRRLLDTGIPAERIVLAPNAASASLRAAVRRIDADPELRAALAQTFSHLREGHPLLLVSCCGRLIETFTPLYRSLARIAAQRPDLDIVCALDDPDHLRADALRRDFSNVHLIAPRDYLAFACLLERASVILAASTEVAQDVAPLGKPVLLLQRDDAGVAVDAANVMPVRAERDGIAASVLTLLSDPVAYERMCLPEPAGEDACRRVVETL |
Sequence similarities
Belongs to the UDP-N-acetylglucosamine 2-epimerase family.
Belongs to the glycosyltransferase 4 family. WecA subfamily.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length770
- Mass (Da)81,554
- Last updated2023-02-22 v1
- ChecksumF10582B01911C2E4
Keywords
- Technical term