A0A915U311 · A0A915U311_9BACT
- ProteinDihydroorotate dehydrogenase
- GenepyrD
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids314 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the conversion of dihydroorotate to orotate.
Catalytic activity
- (S)-dihydroorotate + A = orotate + AH2
Cofactor
Note: Binds 1 FMN per subunit.
Pathway
Pyrimidine metabolism; UMP biosynthesis via de novo pathway.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 29 | FMN (UniProtKB | ChEBI) | |||
Binding site | 53 | substrate | |||
Binding site | 53-54 | FMN (UniProtKB | ChEBI) | |||
Binding site | 77-81 | substrate | |||
Binding site | 107 | FMN (UniProtKB | ChEBI) | |||
Binding site | 135 | FMN (UniProtKB | ChEBI) | |||
Binding site | 135 | substrate | |||
Active site | 138 | Nucleophile | |||
Binding site | 173 | FMN (UniProtKB | ChEBI) | |||
Binding site | 199 | FMN (UniProtKB | ChEBI) | |||
Binding site | 200-201 | substrate | |||
Binding site | 225 | FMN (UniProtKB | ChEBI) | |||
Binding site | 251-252 | FMN (UniProtKB | ChEBI) | |||
Binding site | 273-274 | FMN (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | dihydroorotate dehydrogenase activity | |
Biological Process | 'de novo' pyrimidine nucleobase biosynthetic process | |
Biological Process | 'de novo' UMP biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameDihydroorotate dehydrogenase
- EC number
- Short namesDHOD ; DHODase ; DHOdehase
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Thermodesulfobacteriota > Desulfobulbia > Desulfobulbales > Desulfobulbaceae > Desulfolithobacter
Accessions
- Primary accessionA0A915U311
Proteomes
Subcellular Location
Interaction
Subunit
Heterotetramer of 2 PyrK and 2 PyrD type B subunits.
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 12-294 | Dihydroorotate dehydrogenase catalytic | |||
Sequence similarities
Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily.
Family and domain databases
Sequence
- Sequence statusComplete
- Length314
- Mass (Da)32,942
- Last updated2023-02-22 v1
- MD5 ChecksumE36F0A9A59FC185CC67E416FACD4597A
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AP024233 EMBL· GenBank· DDBJ | BCO10314.1 EMBL· GenBank· DDBJ | Genomic DNA |