A0A915U311 · A0A915U311_9BACT

Function

function

Catalyzes the conversion of dihydroorotate to orotate.

Catalytic activity

Cofactor

FMN (UniProtKB | Rhea| CHEBI:58210 )

Note: Binds 1 FMN per subunit.

Pathway

Pyrimidine metabolism; UMP biosynthesis via de novo pathway.

Features

Showing features for binding site, active site.

131420406080100120140160180200220240260280300
Type
IDPosition(s)Description
Binding site29FMN (UniProtKB | ChEBI)
Binding site53substrate
Binding site53-54FMN (UniProtKB | ChEBI)
Binding site77-81substrate
Binding site107FMN (UniProtKB | ChEBI)
Binding site135FMN (UniProtKB | ChEBI)
Binding site135substrate
Active site138Nucleophile
Binding site173FMN (UniProtKB | ChEBI)
Binding site199FMN (UniProtKB | ChEBI)
Binding site200-201substrate
Binding site225FMN (UniProtKB | ChEBI)
Binding site251-252FMN (UniProtKB | ChEBI)
Binding site273-274FMN (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Functiondihydroorotate dehydrogenase activity
Biological Process'de novo' pyrimidine nucleobase biosynthetic process
Biological Process'de novo' UMP biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Dihydroorotate dehydrogenase
  • EC number
  • Short names
    DHOD
    ; DHODase
    ; DHOdehase

Gene names

    • Name
      pyrD
    • ORF names
      GF1_26900

Organism names

Accessions

  • Primary accession
    A0A915U311

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Heterotetramer of 2 PyrK and 2 PyrD type B subunits.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain12-294Dihydroorotate dehydrogenase catalytic

Sequence similarities

Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    314
  • Mass (Da)
    32,942
  • Last updated
    2023-02-22 v1
  • MD5 Checksum
    E36F0A9A59FC185CC67E416FACD4597A
MDPVSAKNDMDLRVRIGDLRLPNPVLTASGTFGYGREFAHLVDLHRLGGIVVKGISLEPRPGNPPPRIVETACGMLNAIGLENVGVERFVGEKLPWLRETGARIIVNILGDSVDEYARLAGRLAGVEGISGLEVNISCPNVKRGGVAFGTVPEMAASVTEAVKAESDVMVIVKLSPNVTDIVQMARAVEEAGADAVSLINTLIGMAIDIESRRPALANVIGGLSGPAIKPVALRMVYQVASSVRIPVIGIGGITTADDAIEFLLAGATAVQVGTANFYQPSAAEEIIDGITEYLARHGHLSVREIIGGLQTGKE

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AP024233
EMBL· GenBank· DDBJ
BCO10314.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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