A0A915BS86 · A0A915BS86_PARUN
- ProteinSphingomyelin phosphodiesterase
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids611 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Converts sphingomyelin to ceramide.
Catalytic activity
- a sphingomyelin + H2O = phosphocholine + an N-acylsphing-4-enine + H+This reaction proceeds in the forward direction.
Cofactor
Note: Binds 2 Zn2+ ions per subunit.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 160 | Zn2+ 1 (UniProtKB | ChEBI) | |||
Binding site | 162 | Zn2+ 1 (UniProtKB | ChEBI) | |||
Binding site | 233 | Zn2+ 2 (UniProtKB | ChEBI) | |||
Binding site | 233 | Zn2+ 1 (UniProtKB | ChEBI) | |||
Binding site | 273 | Zn2+ 2 (UniProtKB | ChEBI) | |||
Binding site | 380 | Zn2+ 2 (UniProtKB | ChEBI) | |||
Binding site | 414 | Zn2+ 2 (UniProtKB | ChEBI) | |||
Binding site | 416 | Zn2+ 1 (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | extracellular space | |
Cellular Component | lysosome | |
Molecular Function | acid sphingomyelin phosphodiesterase activity | |
Molecular Function | hydrolase activity, acting on glycosyl bonds | |
Molecular Function | metal ion binding | |
Biological Process | ceramide biosynthetic process | |
Biological Process | sphingomyelin catabolic process |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameSphingomyelin phosphodiesterase
- EC number
Organism names
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Nematoda > Chromadorea > Rhabditida > Spirurina > Ascaridomorpha > Ascaridoidea > Ascarididae > Parascaris
Accessions
- Primary accessionA0A915BS86
Proteomes
Subcellular Location
PTM/Processing
Features
Showing features for signal, chain, disulfide bond.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Signal | 1-29 | ||||
Chain | PRO_5036849205 | 30-611 | Sphingomyelin phosphodiesterase | ||
Disulfide bond | 44↔119 | ||||
Disulfide bond | 47↔112 | ||||
Disulfide bond | 75↔86 | ||||
Disulfide bond | 175↔180 | ||||
Disulfide bond | 181↔205 | ||||
Disulfide bond | 340↔388 | ||||
Disulfide bond | 537↔541 | ||||
Keywords
- PTM
Structure
Sequence
- Sequence statusComplete
- Length611
- Mass (Da)70,829
- Last updated2023-02-22 v1
- Checksum46683936EB62D026
Keywords
- Technical term