A0A915BS86 · A0A915BS86_PARUN

Function

function

Converts sphingomyelin to ceramide.

Catalytic activity

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 2 Zn2+ ions per subunit.

Features

Showing features for binding site.

161150100150200250300350400450500550600
TypeIDPosition(s)Description
Binding site160Zn2+ 1 (UniProtKB | ChEBI)
Binding site162Zn2+ 1 (UniProtKB | ChEBI)
Binding site233Zn2+ 2 (UniProtKB | ChEBI)
Binding site233Zn2+ 1 (UniProtKB | ChEBI)
Binding site273Zn2+ 2 (UniProtKB | ChEBI)
Binding site380Zn2+ 2 (UniProtKB | ChEBI)
Binding site414Zn2+ 2 (UniProtKB | ChEBI)
Binding site416Zn2+ 1 (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentextracellular space
Cellular Componentlysosome
Molecular Functionacid sphingomyelin phosphodiesterase activity
Molecular Functionhydrolase activity, acting on glycosyl bonds
Molecular Functionmetal ion binding
Biological Processceramide biosynthetic process
Biological Processsphingomyelin catabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Sphingomyelin phosphodiesterase
  • EC number

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Nematoda > Chromadorea > Rhabditida > Spirurina > Ascaridomorpha > Ascaridoidea > Ascarididae > Parascaris

Accessions

  • Primary accession
    A0A915BS86

Proteomes

Subcellular Location

Keywords

  • Cellular component

PTM/Processing

Features

Showing features for signal, chain, disulfide bond.

Type
IDPosition(s)Description
Signal1-29
ChainPRO_503684920530-611Sphingomyelin phosphodiesterase
Disulfide bond44↔119
Disulfide bond47↔112
Disulfide bond75↔86
Disulfide bond175↔180
Disulfide bond181↔205
Disulfide bond340↔388
Disulfide bond537↔541

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain40-123Saposin B-type

Sequence similarities

Belongs to the acid sphingomyelinase family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    611
  • Mass (Da)
    70,829
  • Last updated
    2023-02-22 v1
  • Checksum
    46683936EB62D026
DMCTTKLRRPFVQFFILIFILLSGSSTNGQLVSRASNVRNVLRCIGCRATVEAFRFIYGQNRTRDAIINIASYICEHFVQRETVVCYGMATQFREEILYVVDKLLLQPDRLCGLFIDGCDKSFNPFSKWNVTIPPKRADIEYPTYPAMRKRNLRVLQISDLHIDKYYTPGSVANCESPLCCQADSATEAGTTKKVAGYWGTQAACDVPYWTIEHMFRNINRTQKFDYILLSGDYMSHLDWAYTKQGHLEMIINLTSTLDHFFPGTPVFWTLGNHEGVPVNSFAPHSIPEKFQPRWLYSQLKESQRRWISQEALQTIAYRGSFTVQLFEGLRLISLNTGYCETTNFWLYLNETDPDGTLSWLVSELYQAENEKQYVHILSHIPPGNIECLEGWASNYYKIVNRFSNTIKAQFFGHIHIDSFTVFYEDMNDDASMPTNVLFSSPSVTTFSGLNPAYRTYEIEAGLQYHVIDYTTYFLNLTKANLERDPEWELLYSAKAEYNLPDLSPSSINQLIDRIDLEPKIYATFLKNSVRRDDYSCEGKCRFELLCQLRRGHRNATLCSHVGQQRISFSKYPLYRQVRLRVDQLKSRRNAAKRFSNDAKKKLFAILRDSY

Keywords

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
Help