A0A915BH67 · A0A915BH67_PARUN

Function

function

ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the membrane-bound receptor, and returning it to the cytosol to initiate a new round of targeting.

Features

Showing features for binding site, active site.

134150100150200250300
TypeIDPosition(s)Description
Binding site27-34ATP (UniProtKB | ChEBI)
Active site56
Binding site237ATP (UniProtKB | ChEBI)
Binding site264ATP (UniProtKB | ChEBI)
Binding site279Zn2+ (UniProtKB | ChEBI); ligand shared between dimeric partners
Binding site282Zn2+ (UniProtKB | ChEBI); ligand shared between dimeric partners

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular ComponentGET complex
Molecular FunctionATP binding
Molecular FunctionATP hydrolysis activity
Molecular Functionmetal ion binding
Biological Processpost-translational protein targeting to endoplasmic reticulum membrane
Biological Processprotein insertion into ER membrane

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    ATPase ASNA1 homolog
  • EC number
  • Alternative names
    • Arsenical pump-driving ATPase homolog
    • Arsenite-stimulated ATPase

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Nematoda > Chromadorea > Rhabditida > Spirurina > Ascaridomorpha > Ascaridoidea > Ascarididae > Parascaris

Accessions

  • Primary accession
    A0A915BH67

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Homodimer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain20-329Anion-transporting ATPase-like

Sequence similarities

Belongs to the arsA ATPase family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    341
  • Mass (Da)
    37,834
  • Last updated
    2023-02-22 v1
  • Checksum
    D87E8147A0813B2D
MMDEDLEPTLRNVIEQNTLKWIFVGGKGGVGKTTCSCSLAVKLAEVRRSVLIISTDPAHNISDAFAQKFGKTPTLVNGFQNLYAMEIDASLGTDSSAQMASASNVAEGDMLGMGRQVLQELAGGLPGIDEAMSFSQMIKLIQSMDFEVVVFDTAPTGHTLRLLHFPDIIENTLGKFLNLQSSFAPLISQMGGMLGLGEVSADETANKMRETLDVVKRINAQFKNPDLTTFICVCIAEFLSLYETERLIQELTKQNIDTHNVVVNQLLFPEEDENGHIKCKKCNARYSIQNKYLEQIADLYEDFNVTKLPLLDNEVRGADQIRRFSAYLLDPYDPRKHPSGL

Keywords

Genome annotation databases

Similar Proteins

Disclaimer

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