A0A915AIM3 · A0A915AIM3_PARUN
- ProteinGPI mannosyltransferase 1
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids713 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the first alpha-1,4-mannose to GlcN-acyl-PI during GPI precursor assembly.
S-adenosyl-L-methionine-dependent methyltransferase that catalyzes four methylations of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine methyl ester. The four successive methylation reactions represent the second step of diphthamide biosynthesis.
Catalytic activity
- 2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + 4 S-adenosyl-L-methionine = diphthine methyl ester-[translation elongation factor 2] + 4 S-adenosyl-L-homocysteine + 3 H+
Pathway
Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.
Protein modification; peptidyl-diphthamide biosynthesis.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | endoplasmic reticulum membrane | |
Cellular Component | glycosylphosphatidylinositol-mannosyltransferase I complex | |
Molecular Function | alpha-1,4-mannosyltransferase activity | |
Molecular Function | diphthine synthase activity | |
Molecular Function | glycolipid mannosyltransferase activity | |
Biological Process | GPI anchor biosynthetic process | |
Biological Process | methylation | |
Biological Process | protein histidyl modification to diphthamide |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameGPI mannosyltransferase 1
- EC number
- Alternative names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Nematoda > Chromadorea > Rhabditida > Spirurina > Ascaridomorpha > Ascaridoidea > Ascarididae > Parascaris
Accessions
- Primary accessionA0A915AIM3
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Endoplasmic reticulum membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Transmembrane | 191-220 | Helical | |||
Transmembrane | 240-263 | Helical | |||
Transmembrane | 305-326 | Helical | |||
Transmembrane | 338-362 | Helical | |||
Transmembrane | 374-397 | Helical | |||
Transmembrane | 403-424 | Helical | |||
Keywords
- Cellular component
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 438-678 | Tetrapyrrole methylase | |||
Sequence similarities
Belongs to the PIGM family.
Belongs to the diphthine synthase family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length713
- Mass (Da)80,760
- Last updated2023-02-22 v1
- Checksum626B9200657724A9
Keywords
- Technical term