A0A915AIM3 · A0A915AIM3_PARUN

Function

function

Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the first alpha-1,4-mannose to GlcN-acyl-PI during GPI precursor assembly.
S-adenosyl-L-methionine-dependent methyltransferase that catalyzes four methylations of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine methyl ester. The four successive methylation reactions represent the second step of diphthamide biosynthesis.

Catalytic activity

Pathway

Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.
Protein modification; peptidyl-diphthamide biosynthesis.

GO annotations

AspectTerm
Cellular Componentendoplasmic reticulum membrane
Cellular Componentglycosylphosphatidylinositol-mannosyltransferase I complex
Molecular Functionalpha-1,4-mannosyltransferase activity
Molecular Functiondiphthine synthase activity
Molecular Functionglycolipid mannosyltransferase activity
Biological ProcessGPI anchor biosynthetic process
Biological Processmethylation
Biological Processprotein histidyl modification to diphthamide

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    GPI mannosyltransferase 1
  • EC number
  • Alternative names
    • GPI mannosyltransferase I
    • Phosphatidylinositol-glycan biosynthesis class M protein

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Nematoda > Chromadorea > Rhabditida > Spirurina > Ascaridomorpha > Ascaridoidea > Ascarididae > Parascaris

Accessions

  • Primary accession
    A0A915AIM3

Proteomes

Subcellular Location

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane191-220Helical
Transmembrane240-263Helical
Transmembrane305-326Helical
Transmembrane338-362Helical
Transmembrane374-397Helical
Transmembrane403-424Helical

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain438-678Tetrapyrrole methylase

Sequence similarities

Belongs to the PIGM family.
Belongs to the diphthine synthase family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    713
  • Mass (Da)
    80,760
  • Last updated
    2023-02-22 v1
  • Checksum
    626B9200657724A9
MRKRGGIVSTNVECTSDSDSESGEERVVAWTTAKIFITAFLFRALLVCYGPVHDYLFDVNFTDVDYRVFTDAAAYVRRGRSPYERATYRYTPLLAWLLVPNTVWPEFGKMIFCVLDIAVGYDCYETATAPLLARKPSKRTHSRITREAKQAIVIFWLANPLTAIISARGNADVIVCAAVVHTLKLLLNNQWLLAAVVHGLIAIQLKIYPLIYLPSIFLYISNVRIATGYLDCCRKFLLNWKGFVFVLVSLMSFALSILVYFLLYGNRYIYESLLYHISRTDTRHNFSPYFYSFYLLDGETTFSQLVGRIAFGPQAALILLISVRFYDDLPFCWMLLTMAFIAFNKVCTSQYFLWFISLLPIAQRSIEMSLKRSVVLSSMWVIAQAIWLLAAYFLEFWGVNSFLFIWLASLLFFSTNVFIVAQLITHYRDPFQSVVMVFYLVGLGLGDAEDITVKGLNTIKKCVRVYLEAYTSILSYALDKSKLERFYGKEVIMADRELVEQHSDELLAGAEVSDVCMLVVGDPFGATTHSSLVLRARDLHIPVKVIHNASIINAVACCGLQLYSFGETVSIVMWTDSWQPDSYYDKIAANRSRGLHTLCLLDIKVKEQSVDNLLRGREIYEPPRYMSCSEAAKQLLQIAERKEKAGVQPAYSAETLCVGLARIGWNNQKIVSCSLSEMVLVDMGEPLHSLVIVGEMHPVEIDMLKAFAVRSAS

Keywords

Genome annotation databases

Similar Proteins

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