A0A914QVN7 · A0A914QVN7_9BILA
- ProteinO-acyltransferase
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids464 (go to sequence)
- Protein existenceInferred from homology
- Annotation score5/5
Function
Catalytic activity
- (9Z)-octadecenoate + 1,2-di-(9Z-octadecenoyl)-glycerol + H+ = 1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2OThis reaction proceeds in the forward direction.
- (9Z)-octadecenoyl-CoA + 1,2-di-(9Z-octadecenoyl)-sn-glycerol = 1,2,3-tri-(9Z-octadecenoyl)-glycerol + CoAThis reaction proceeds in the forward direction.
- (9Z)-octadecenoyl-CoA + 1,3-di-(9Z-octadecenoyl)-glycerol = 1,2,3-tri-(9Z-octadecenoyl)-glycerol + CoAThis reaction proceeds in the forward direction.
- (9Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-glycerol = 1,2-di-(9Z-octadecenoyl)-glycerol + CoAThis reaction proceeds in the forward direction.
- (9Z)-octadecenoyl-CoA + 1-O-(9Z-octadecenyl)-glycerol = 1-O-(9Z-octadecyl)-3-(9Z-octadecenoyl)-glycerol + CoAThis reaction proceeds in the forward direction.
- (9Z)-octadecenoyl-CoA + 1-O-(9Z-octadecyl)-3-(9Z-octadecenoyl)-glycerol = 1-O-(9Z-octadecenyl)-2,3-di-(9Z-octadecenoyl)glycerol + CoAThis reaction proceeds in the forward direction.
- (9Z)-octadecenoyl-CoA + 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-3-(9Z)-octadecenoyl-sn-glycerol + CoAThis reaction proceeds in the forward direction.
- (9Z)-octadecenoyl-CoA + 2,3-di-(9Z)-octadecenoyl-sn-glycerol = 1,2,3-tri-(9Z-octadecenoyl)-glycerol + CoAThis reaction proceeds in the forward direction.
- (9Z)-octadecenoyl-CoA + 2-(9Z-octadecenoyl)-glycerol = 1,2-di-(9Z-octadecenoyl)-sn-glycerol + CoAThis reaction proceeds in the forward direction.
- 1,2-di-(9Z-octadecenoyl)-sn-glycerol + hexadecanoyl-CoA = 1,2-di-(9Z)-octadecenoyl-3-hexadecanoyl-sn-glycerol + CoAThis reaction proceeds in the forward direction.
- 13-cis-retinol + hexadecanoyl-CoA = 13-cis-retinyl hexadecanoate + CoAThis reaction proceeds in the forward direction.
- 2-(9Z-octadecenoyl)-glycerol + hexadecanoyl-CoA = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + CoAThis reaction proceeds in the forward direction.
- all-trans-retinol + hexadecanoyl-CoA = all-trans-retinyl hexadecanoate + CoAThis reaction proceeds in the forward direction.
- hexadecan-1-ol + hexadecanoyl-CoA = CoA + hexadecanyl hexadecanoateThis reaction proceeds in the forward direction.
- hexadecane-1,2-diol + 2 hexadecanoyl-CoA = 1,2-O,O-dihexadecanoyl-1,2-hexadecanediol + 2 CoAThis reaction proceeds in the forward direction.
- hexadecane-1,2-diol + hexadecanoyl-CoA = 2-hydroxyhexadecyl hexadecanoate + CoAThis reaction proceeds in the forward direction.
Pathway
Lipid metabolism; glycerolipid metabolism.
Features
Showing features for active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Active site | 382 | |||||
Sequence: H |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | endoplasmic reticulum membrane | |
Molecular Function | diacylglycerol O-acyltransferase activity | |
Biological Process | triglyceride biosynthetic process |
Keywords
- Molecular function
Names & Taxonomy
Protein names
- Recommended nameO-acyltransferase
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Nematoda > Chromadorea > Rhabditida > Tylenchina > Panagrolaimomorpha > Panagrolaimoidea > Panagrolaimidae > Panagrolaimus
Accessions
- Primary accessionA0A914QVN7
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Endoplasmic reticulum membrane ; Multi-pass membrane protein
Membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 63-83 | Helical | ||||
Sequence: FWGFFNLAMLLLIVSNARVAL | ||||||
Transmembrane | 112-132 | Helical | ||||
Sequence: LVMLFCSNITCILVFFTEKIL | ||||||
Transmembrane | 144-164 | Helical | ||||
Sequence: VWYIALISAHLTLPVLVTLWL | ||||||
Transmembrane | 170-191 | Helical | ||||
Sequence: FASLALAIIVVEALKLVSYIHV | ||||||
Transmembrane | 249-268 | Helical | ||||
Sequence: LAEFLCFGILGVALCEQWVV | ||||||
Transmembrane | 299-320 | Helical | ||||
Sequence: IIWLLFFYTIFHSSLNLLAEIL | ||||||
Transmembrane | 364-381 | Helical | ||||
Sequence: GYSRLTASVAVFFISAIF | ||||||
Transmembrane | 393-411 | Helical | ||||
Sequence: FRMWAFLAMLSQIPLSMLT | ||||||
Transmembrane | 423-441 | Helical | ||||
Sequence: IVVWLSLLVGQPMAILIYV |
Keywords
- Cellular component
Interaction
Subunit
Homodimer or homotetramer; both forms have similar enzymatic activities.
Structure
Family & Domains
Features
Showing features for compositional bias, region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 1-27 | Polar residues | ||||
Sequence: MTSGSGQQTELRKRRSPSSSSSSEEPR | ||||||
Region | 1-52 | Disordered | ||||
Sequence: MTSGSGQQTELRKRRSPSSSSSSEEPRSKQAQLKKEKASQPPDQPCHSPQDS |
Sequence similarities
Belongs to the membrane-bound acyltransferase family. Sterol o-acyltransferase subfamily.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length464
- Mass (Da)53,733
- Last updated2023-02-22 v1
- ChecksumC949FC20C6906A2A
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 1-27 | Polar residues | ||||
Sequence: MTSGSGQQTELRKRRSPSSSSSSEEPR |
Keywords
- Technical term