A0A914MFZ1 · A0A914MFZ1_MELIC
- Proteinglycerophosphocholine cholinephosphodiesterase
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids484 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
function
Choline-specific glycerophosphodiesterase that hydrolyzes glycerophosphocholine (GPC) and lysophosphatidylcholine (LPC) and contributes to supplying choline to the cells. Has a preference for LPC with short (12:0 and 14:0) or polyunsaturated (18:2 and 20:4) fatty acids. In vitro, hydrolyzes only choline-containing lysophospholipids, such as sphingosylphosphorylcholine (SPC), platelet-activating factor (PAF) and lysoPAF, but not other lysophospholipids.
Catalytic activity
- 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O = 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + phosphocholine + H+This reaction proceeds in the forward direction.
- 1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + H2O = 1-(9Z,12Z-octadecadienoyl)-sn-glycerol + phosphocholine + H+This reaction proceeds in the forward direction.
- 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O = 1-(9Z-octadecenoyl)-sn-glycerol + phosphocholine + H+This reaction proceeds in the forward direction.
- a 1-O-alkyl-sn-glycero-3-phosphocholine + H2O = a 1-O-alkyl-sn-glycerol + phosphocholine + H+This reaction proceeds in the forward direction.
- 1-dodecanoyl-sn-glycero-3-phosphocholine + H2O = 1-dodecanoyl-sn-glycerol + phosphocholine + H+This reaction proceeds in the forward direction.
- 1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycerol + phosphocholine + H+This reaction proceeds in the forward direction.
- 1-tetradecanoyl-sn-glycero-3-phosphocholine + H2O = 1-tetradecanoyl-sn-glycerol + phosphocholine + H+This reaction proceeds in the forward direction.
- sphing-4-enine-phosphocholine + H2O = sphing-4-enine + phosphocholine + H+This reaction proceeds in the forward direction.
- a 1-acyl-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn-glycerol + phosphocholine + H+This reaction proceeds in the forward direction.
- glycero-2-phosphocholine + H2O = phosphocholine + glycerol + H+This reaction proceeds in the forward direction.
Cofactor
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | membrane | |
Biological Process | lipid catabolic process |
Keywords
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameglycerophosphocholine cholinephosphodiesterase
- EC number
- Alternative names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Nematoda > Chromadorea > Rhabditida > Tylenchina > Tylenchomorpha > Tylenchoidea > Meloidogynidae > Meloidogyninae > Meloidogyne > Meloidogyne incognita group
Accessions
- Primary accessionA0A914MFZ1
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Lipid-anchor, GPI-anchor
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 459-479 | Helical | ||||
Sequence: ITLLLVVIEILIVCNFSFYFL |
Keywords
- Cellular component
PTM/Processing
Features
Showing features for signal, chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-19 | |||||
Sequence: MWGLRIFLYVVFSINFCFS | ||||||
Chain | PRO_5036907170 | 20-484 | glycerophosphocholine cholinephosphodiesterase | |||
Sequence: QKEPVGQNLILFLVDANLFNNTDSRMKFGAKTLIENGVEADYLIPVFPTQSYPNWFSLATGLYVENHNFTADFMFDPNNTLFFERDLGVDDLNEKWWRANPAPFWYSVGKAGIDVHCYWFATCHMPYVDLVVQVPLTRRHSFKNDEEHDLYSYIPNIMKYIQKYQVYRKQLVLLRYDGLGKALRTHGEDSEQTVQELSNFDQQVRKIQEEMETWDLLRSTNLIVLSDHGLIKSEEQNQYYIEECIADSTKIKQIANSLAFALIWPEEEEEDTIFFELKFCDQWANLASVDYEGETKEVEPSVGVYRQHEIPERFHWRNSRFIAPIVLIAQPGYQLLTRQIPSTSVSEKFGREWKMLDGWDNENPDLQGIFMARGPAFKSGYKGGPLEMIDIYQLVLNMLEVDPCHPNNGSWERVSEFLSDELEERSYQPQNFGIRNSRPITLLLVVIEILIVCNFSFYFLPTDLF |
Keywords
- PTM
Structure
Sequence
- Sequence statusComplete
- Length484
- Mass (Da)56,684
- Last updated2023-02-22 v1
- Checksum5DFC332042D11A4E
Keywords
- Technical term