A0A914L0D4 · A0A914L0D4_MELIC
- ProteinPresenilin
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids550 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
function
Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namePresenilin
- EC number
Organism names
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Nematoda > Chromadorea > Rhabditida > Tylenchina > Tylenchomorpha > Tylenchoidea > Meloidogynidae > Meloidogyninae > Meloidogyne > Meloidogyne incognita group
Accessions
- Primary accessionA0A914L0D4
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Endoplasmic reticulum membrane ; Multi-pass membrane protein
Golgi apparatus membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 97-118 | Helical | ||||
Sequence: LFVPVSLCMAVVILTMMTVGYY | ||||||
Transmembrane | 146-167 | Helical | ||||
Sequence: LANAGILLVVIIVMTVILIVLY | ||||||
Transmembrane | 174-194 | Helical | ||||
Sequence: IIHAWLMLSSLMLLSMFTLSF | ||||||
Transmembrane | 206-226 | Helical | ||||
Sequence: IDYITLGIFLWNWCVLGMICI | ||||||
Transmembrane | 233-251 | Helical | ||||
Sequence: LLQQFYLVSVSALMALMFI | ||||||
Transmembrane | 257-276 | Helical | ||||
Sequence: WSVWSILAVLSIWDLVAVLC | ||||||
Transmembrane | 489-511 | Helical | ||||
Sequence: VTIACYVSILVGLAFTLMLLALF | ||||||
Transmembrane | 517-536 | Helical | ||||
Sequence: ALPISIFAGITFFFGTRWLI |
Keywords
- Cellular component
Interaction
Subunit
Homodimer.
Structure
Family & Domains
Features
Showing features for compositional bias, region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 1-38 | Polar residues | ||||
Sequence: MELATIPQNSSAMSTTGGTNGSPQHNQESGSNEQNNQQ | ||||||
Region | 1-79 | Disordered | ||||
Sequence: MELATIPQNSSAMSTTGGTNGSPQHNQESGSNEQNNQQKERVGGKKKTKQRPVSSDSKLCESAQRQNPSKRRRDSLTSE | ||||||
Compositional bias | 39-54 | Basic and acidic residues | ||||
Sequence: KERVGGKKKTKQRPVS | ||||||
Compositional bias | 65-79 | Basic and acidic residues | ||||
Sequence: RQNPSKRRRDSLTSE | ||||||
Region | 324-456 | Disordered | ||||
Sequence: ENEEEEQQRVENEQEQQLPSTSTSNNKTRTKREGSATSTDGLLEKDEKIESIKREKSSGEQSISRSRSAPGRPTSSSKRQNVTTSDDTIITIIGSSNDGAGTSSSQPTTSKESGRSPRRSRSAQNFGGNGDEN | ||||||
Compositional bias | 336-360 | Polar residues | ||||
Sequence: EQEQQLPSTSTSNNKTRTKREGSAT | ||||||
Compositional bias | 361-384 | Basic and acidic residues | ||||
Sequence: STDGLLEKDEKIESIKREKSSGEQ | ||||||
Compositional bias | 385-454 | Polar residues | ||||
Sequence: SISRSRSAPGRPTSSSKRQNVTTSDDTIITIIGSSNDGAGTSSSQPTTSKESGRSPRRSRSAQNFGGNGD |
Domain
The PAL motif is required for normal active site conformation.
Sequence similarities
Belongs to the peptidase A22A family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length550
- Mass (Da)61,041
- Last updated2023-02-22 v1
- Checksum1E76C4D199829FDA
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 1-38 | Polar residues | ||||
Sequence: MELATIPQNSSAMSTTGGTNGSPQHNQESGSNEQNNQQ | ||||||
Compositional bias | 39-54 | Basic and acidic residues | ||||
Sequence: KERVGGKKKTKQRPVS | ||||||
Compositional bias | 65-79 | Basic and acidic residues | ||||
Sequence: RQNPSKRRRDSLTSE | ||||||
Compositional bias | 336-360 | Polar residues | ||||
Sequence: EQEQQLPSTSTSNNKTRTKREGSAT | ||||||
Compositional bias | 361-384 | Basic and acidic residues | ||||
Sequence: STDGLLEKDEKIESIKREKSSGEQ | ||||||
Compositional bias | 385-454 | Polar residues | ||||
Sequence: SISRSRSAPGRPTSSSKRQNVTTSDDTIITIIGSSNDGAGTSSSQPTTSKESGRSPRRSRSAQNFGGNGD |
Keywords
- Technical term