A0A914L0D4 · A0A914L0D4_MELIC

Function

function

Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentapical plasma membrane
Cellular Componentcell cortex
Cellular Componentcell surface
Cellular Componentciliary rootlet
Cellular Componentdendritic shaft
Cellular Componentendoplasmic reticulum membrane
Cellular ComponentGolgi membrane
Cellular Componentgrowth cone
Cellular Componentlysosomal membrane
Cellular Componentmembrane raft
Cellular Componentmitochondrial inner membrane
Cellular Componentneuromuscular junction
Cellular Componentneuronal cell body
Cellular Componentnucleus
Cellular Componentperinuclear region of cytoplasm
Cellular ComponentZ disc
Molecular Functionaspartic endopeptidase activity, intramembrane cleaving
Biological Processamyloid precursor protein catabolic process
Biological Processamyloid-beta metabolic process
Biological Processcalcium ion transport
Biological Processmembrane protein ectodomain proteolysis
Biological Processnegative regulation of apoptotic process
Biological ProcessNotch receptor processing
Biological ProcessNotch signaling pathway
Biological Processprotein processing

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Presenilin
  • EC number

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Nematoda > Chromadorea > Rhabditida > Tylenchina > Tylenchomorpha > Tylenchoidea > Meloidogynidae > Meloidogyninae > Meloidogyne > Meloidogyne incognita group

Accessions

  • Primary accession
    A0A914L0D4

Proteomes

Subcellular Location

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane97-118Helical
Transmembrane146-167Helical
Transmembrane174-194Helical
Transmembrane206-226Helical
Transmembrane233-251Helical
Transmembrane257-276Helical
Transmembrane489-511Helical
Transmembrane517-536Helical

Keywords

Interaction

Subunit

Homodimer.

Family & Domains

Features

Showing features for compositional bias, region.

TypeIDPosition(s)Description
Compositional bias1-38Polar residues
Region1-79Disordered
Compositional bias39-54Basic and acidic residues
Compositional bias65-79Basic and acidic residues
Region324-456Disordered
Compositional bias336-360Polar residues
Compositional bias361-384Basic and acidic residues
Compositional bias385-454Polar residues

Domain

The PAL motif is required for normal active site conformation.

Sequence similarities

Belongs to the peptidase A22A family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    550
  • Mass (Da)
    61,041
  • Last updated
    2023-02-22 v1
  • Checksum
    1E76C4D199829FDA
MELATIPQNSSAMSTTGGTNGSPQHNQESGSNEQNNQQKERVGGKKKTKQRPVSSDSKLCESAQRQNPSKRRRDSLTSEKMMEEQALKYGASHVIHLFVPVSLCMAVVILTMMTVGYYSKAGEYLPYTPFHGKTTDGAGEILLQSLANAGILLVVIIVMTVILIVLYKSKCYKIIHAWLMLSSLMLLSMFTLSFIEELFRNYNIPIDYITLGIFLWNWCVLGMICIHWQGPLLLQQFYLVSVSALMALMFIKHLPEWSVWSILAVLSIWDLVAVLCPKGPLRILVETAQKRDEPIFPALIYSSGILYMYTLTGMGQVNNAVDYENEEEEQQRVENEQEQQLPSTSTSNNKTRTKREGSATSTDGLLEKDEKIESIKREKSSGEQSISRSRSAPGRPTSSSKRQNVTTSDDTIITIIGSSNDGAGTSSSQPTTSKESGRSPRRSRSAQNFGGNGDENNLVEERGVKLGLGDFIFYSVLVGKASSYGDWNVTIACYVSILVGLAFTLMLLALFRKALPALPISIFAGITFFFGTRWLITPLMKEIALRQLIL

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias1-38Polar residues
Compositional bias39-54Basic and acidic residues
Compositional bias65-79Basic and acidic residues
Compositional bias336-360Polar residues
Compositional bias361-384Basic and acidic residues
Compositional bias385-454Polar residues

Keywords

Genome annotation databases

Similar Proteins

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