A0A914KR54 · A0A914KR54_MELIC

Function

Catalytic activity

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Pathway

Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 1/3.
Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 2/3.
Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 3/3.

Features

Showing features for active site.

TypeIDPosition(s)Description
Active site286Nucleophile
Active site370
Active site372

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Functionamino acid binding
Molecular Functionaspartate carbamoyltransferase activity
Molecular FunctionATP binding
Molecular Functioncarbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
Molecular Functiondihydroorotase activity
Molecular Functionmetal ion binding
Biological Process'de novo' pyrimidine nucleobase biosynthetic process
Biological Processcitrulline biosynthetic process
Biological Processglutamine metabolic process
Biological ProcessUTP biosynthetic process

Keywords

Names & Taxonomy

Protein names

  • Submitted names
    • CAD protein

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Nematoda > Chromadorea > Rhabditida > Tylenchina > Tylenchomorpha > Tylenchoidea > Meloidogynidae > Meloidogyninae > Meloidogyne > Meloidogyne incognita group

Accessions

  • Primary accession
    A0A914KR54

Proteomes

Subcellular Location

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain550-742ATP-grasp
Domain1110-1301ATP-grasp
Domain1369-1538MGS-like

Sequence similarities

In the 2nd section; belongs to the CarB family.
In the 3rd section; belongs to the metallo-dependent hydrolases superfamily. DHOase family. CAD subfamily.
In the C-terminal section; belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
In the N-terminal section; belongs to the CarA family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    2,272
  • Mass (Da)
    255,017
  • Last updated
    2023-02-22 v1
  • Checksum
    5BB15B6F56BA1C5F
MISLATQQNINDEFEEINRFATLYLELPEGLKQQTQIRANLFGATKSISGEIVFQTGMCGYIESLTDPSYAQQLLVLTYPLIGNYGVPKFAKCDPKWPELLTCGFESDRIWPAALIVDRICEEGEYSHYEAATSLSKWLCDQGVTGLCGIDTRMLTKIIRTYGTLRAKIVIDSDRQDDIQFVNINEQNLVASVSRKSPKLFGNESDNSLFNVLAIDCGIKFNQIRCLLQRNCKVMVVPWDYEFNISDYDGLFISNGPGDPAKCTSLINRIASLLFSGTNIPIFGICLGHQLLASAAGANTYKMRFGNRGHNLPALHASSGRCFITAQNHGFAVDCNSLPKNWNELFINANDRSNEGMIHESKPYFSVQFHPEHCAGPDDTEWLFDVFVESMKIFKTTKDSVNLNQLINERLSFTTNYRDEVSNQKKVLILGSGGLSIGQAGEFDYSGSQAIKALREMGIKSILVNPNVATVQTTKGFADRAYFLPVTKEFVTEIIKKERPTGLLCTFGGQTALNCAIDLFRDGVLKDFNVRVLGTPIEAIVRTEDRDLFKHEILKIGERVAEGSAATNIIDAEKAAEKIGYPVLVRAAYALGGLGSGFATNKEELNVIAKQAFAHSNQVLIDKSIQGWKEIEYEVVRDAYDNCISVCNMENIDPVGIHTGESIVVAPSQTLNDHEYFMLRATALRVIRHFGIIGECNIQFALNPENMEYYIIEVNARLSRSSALASKATGYPLAYIAAKLALGASLPELQNSVTGETTACFEPSLDYCVVKVPRWDLGKFARVSTKIGSSMKSVGEVMAIGRSFEEAFQKALRMVNDHYEGFSPYLFKRKVRREDLQEPTDLRIFALARALFSEELKCDADQDYIDFVYKLCKINKWFLHRMRNIVDMYKRLQHRCSQYCSEKIKYNKHTFPALLKEAKQIGFSDAQIAKLIESTELNVKNLRKQFGIFPYVKQIDTVAAEWPAKTNYLYLTYNGNEHDIDFYDNTDSVIVLGSGVYRIGSSVEFDACSVGCVEELKRMGRQTIMINCNPETVSTDYDKCDRLYFEEISLEVVSQIYEYERPSGIILAFGGQAANNIALSLDSNLTGLNFRVFGTAPKFIDEAEDRFKFSRALDELKIEQPKWKNAKNISDAKIFCNSVGFPCLIRPSYVLSGAAMNVAHCVEDLHQFLNVAHSVADERTVVVSKFIENAKEIDVDVVCLNGKVLCMAISEHVENAGIHSGDATLVTPPQDLNEETRISINKIVRSIARRFMAVGPFNLQLIAKDNKLFVIECNLRVSRSFPFISKTLDFDFVGLATRAMMFSGEPKDFTFKPPPKPNKFGVKVPQFSFSRLSGADVVMGVEMLSTGEVACFGLSRQEAYLKGLLSTGFQLPTRAIFLSIGGPFKSEMLESVQKLFKLGYVLYGSKGTAHYYSCKGIPIKQLEWPFDDITSGEDWNDLSTSKMSTVNTTITDYVAKKNIDFMINLPIRGSGTYRVSAYRTRGYKTRRMAIDNGIPLITDIKCAKLFIQALNELEIKPNNSKIPPVNLHIDSISNECLVRMPGLIDVHVHMREPGGEHKETWESGTRAAISGGVTMVLAMPNTNPPLIDDASFTLIDKLASSNALCDYALYMGATMDNVKDGSFIGQKCAGLKMYLNQTFAVLQLPKMGQWMKHMRNFPSNRPIVVHAEGQTLAAVLYCAKLCKRALHICHVSTSEEINLIRSAKIEGQPVTCEVCPHHLFLTADQLPEGVKEVRPRLAISVDDCKALWENLEIIDCFSTDHAPHTWDEKCSANPPPGFPGIEYMLPLLLQAVKDGKLTEKQLIDRLYTNPRRIFELPEQPNTYIEVDKSEIWRIPKEGGFSKAGWTPFAGREVCGRVKTVVIRGVTVYVDGQFLVSPGFGTNVRLASNDNEDESAMPTSELLHLSSDFKYSDTDEEKHLRPSPDRPLNSTTETSLWYGRNVISVESFTKPMVKQVLDLALRCEKVVRERSLVFKDFLRQFIVCPMFFEPSTRTKCSFECAMKRLDGEILDFRNESSSEKKGETFEDTIQTIGLYTDLIVLRHPSKDACELALQAVSTLDRPVPIINAGDGTGEHPTQALLDLYTIREKLSSINHKTIAIVGDLKYGRTVHSLAKILCLYDGIILHYVSPSKSLGMPEHVKQYVEQYAKQFNKEIIQKEFTSLEDGIHNVDVIYMTRIQKERFTDSSEYEKIKGKFILTPKLLNMASTRTEQETFFSTSDRRHPTPIVMHPLPRNDEISTELDTDERVVFMKQAGYGLYVRMALLTLVLRKDF

Keywords

Genome annotation databases

Similar Proteins

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