A0A8X8RMJ2 · A0A8X8RMJ2_9CAUD
- ProteinNAD(+)--arginine ADP-ribosyltransferase
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids685 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
function
ADP-ribosyltransferase that efficiently ADP-ribosylates one of the two alpha subunits of host RNA polymerase RPOA on an arginine located in the C-terminal region. ADP-ribosylation of RPOA alpha subunit enhances the transcription of viral early genes. Also ribosylates RPOA subunits beta, beta' and sigma 70 and performs an autoribosylation reaction.
Catalytic activity
- L-arginyl-[protein] + NAD+ = N(omega)-(ADP-D-ribosyl)-L-arginyl-[protein] + nicotinamide + H+
Features
Showing features for site, active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Site | 6-7 | Cleavage | ||||
Sequence: EL | ||||||
Active site | 589 | |||||
Sequence: E |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | extracellular region | |
Cellular Component | virion component | |
Molecular Function | NAD+-protein-arginine ADP-ribosyltransferase activity | |
Molecular Function | nucleotidyltransferase activity | |
Biological Process | regulation of viral transcription |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameNAD(+)--arginine ADP-ribosyltransferase
- EC number
Organism names
- Organism
- Taxonomic lineageViruses > Duplodnaviria > Heunggongvirae > Uroviricota > Caudoviricetes > Straboviridae > Tevenvirinae > Tequatrovirus
Accessions
- Primary accessionA0A8X8RMJ2
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Note: About 25-50 copies per virion. This protein is injected into the bacterial cell along with the viral DNA.
Keywords
- Cellular component
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_5042300903 | 1-685 | NAD+--arginine ADP-ribosyltransferase | |||
Sequence: MELITELFDGASAPVVNLNPKHKIPQIFAIQAGEESVLPGFRFCTYTSGGDTNKNVKPGDKMMHIVMIGVNEKLSLVKLKNLGGNPIGVINAVFDTALQTMKQYKIDACLFRVLKSKTNGAARQMQVIADRLVRTKGAGRYVLLKEIWDYDKKYAYIMVYRKNANLEDIPGVPPISTELFTKVESKVGDVYVDVKTGNAVPKAVAVAASIALENDKRTDQAVIQKTKISRRLAAQAQYSTVDASLQGDSFAAKKYQELESKVPVYKAEGPMNSGVIQIGSNFGKGAIGGMRSASRFKSNDYELESFRNHIALAHARLRDPSIKLQSDTTYQGSQEYLKNKEFFDYKTDKILSDLADINISNSFDVIKKIINDLVKGSKATPDEKTAIIQFVMNGIYKLINESAAQAYEYASTEVTPKGLTQAESDVIEDYCADSYVEMNSFLLGKPDSTREEYMERAIKHIETLDSAFAKGSVLPPGTTLYRGQEVTFKTLRHNIENKMFYFKNFVSTSLKPNIFGEHGKNYMALDDSGAVFSGEGEGSVDAEDLMHMGSHSTYANEDAETSVGMVIKGAERIKVIVPGHLSGFPSEAEVILPRGILLKINKVSTYMMKETAYNKYLIEGTIVPPSEQLEESVYDGDHLMETGEVRPMAGFNQFLVEESKEEENEVSQILASLVNINGMSKKFKM |
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 416-620 | ADP ribosyltransferase | ||||
Sequence: PKGLTQAESDVIEDYCADSYVEMNSFLLGKPDSTREEYMERAIKHIETLDSAFAKGSVLPPGTTLYRGQEVTFKTLRHNIENKMFYFKNFVSTSLKPNIFGEHGKNYMALDDSGAVFSGEGEGSVDAEDLMHMGSHSTYANEDAETSVGMVIKGAERIKVIVPGHLSGFPSEAEVILPRGILLKINKVSTYMMKETAYNKYLIEG |
Sequence similarities
Belongs to the Tevenvirinae NAD(+)--arginine ADP-ribosyltransferase family.
Family and domain databases
Sequence
- Sequence statusComplete
- Length685
- Mass (Da)75,860
- Last updated2022-12-14 v1
- Checksum8644818614350F77