A0A8X8BIG1 · A0A8X8BIG1_POLSE

Function

function

G-protein-coupled receptor that senses changes in the extracellular concentration of calcium ions and plays a key role in maintaining calcium homeostasis. Senses fluctuations in the circulating calcium concentration and modulates the production of parathyroid hormone (PTH) in parathyroid glands. The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system. The G-protein-coupled receptor activity is activated by a co-agonist mechanism: aromatic amino acids, such as Trp or Phe, act concertedly with divalent cations, such as calcium or magnesium, to achieve full receptor activation.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentplasma membrane
Molecular Functioncalcium ion binding
Molecular FunctionG protein-coupled receptor activity
Biological Processdetection of calcium ion
Biological Processintracellular calcium ion homeostasis
Biological Processregulation of calcium ion transport

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Extracellular calcium-sensing receptor

Gene names

    • Name
      Casr_28
    • ORF names
      GTO96_0013031

Organism names

  • Taxonomic identifier
  • Strain
    • Bchr_013
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Polypteriformes > Polypteridae > Polypterus

Accessions

  • Primary accession
    A0A8X8BIG1

Proteomes

Subcellular Location

Cell membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane340-368Helical
Transmembrane396-417Helical
Transmembrane454-473Helical
Transmembrane479-501Helical
Transmembrane555-576Helical
Transmembrane588-608Helical
Transmembrane1201-1226Helical
Transmembrane1238-1259Helical
Transmembrane1271-1293Helical
Transmembrane1314-1333Helical
Transmembrane1359-1381Helical
Transmembrane1393-1415Helical
Transmembrane1421-1443Helical

Keywords

PTM/Processing

Features

Showing features for signal, chain.

Type
IDPosition(s)Description
Signal1-21
ChainPRO_503646384222-1631Extracellular calcium-sensing receptor

Keywords

Interaction

Subunit

Homodimer; disulfide-linked. Interacts with VCP and RNF19A. Interacts with ARRB1.

Family & Domains

Features

Showing features for region, compositional bias, domain.

Type
IDPosition(s)Description
Region262-306Disordered
Compositional bias274-292Polar residues
Domain1201-1465G-protein coupled receptors family 3 profile
Compositional bias1483-1515Polar residues
Region1483-1524Disordered
Region1577-1631Disordered

Sequence similarities

Belongs to the G-protein coupled receptor 3 family.
Belongs to the SID1 family.

Keywords

Family and domain databases

Protein family/group databases

Sequence

  • Sequence status
    Fragment
  • Length
    1,631
  • Mass (Da)
    182,904
  • Last updated
    2022-12-14 v1
  • MD5 Checksum
    A3DE33F286F5D56B8689C568E4F3D018
MGSLSLAAAMLLASLLVGCQCQRKLPSSPQQAEFNRVYSGAVSRTTENIYSFSYTSRAGQVGGARRGTKQTLGKQVDAIRVFASADSKDLHYPVIFVVRQQKGVFYQRTYKYQEVSRTLCPLEPEEEELSAEHSLFIDVASMAPANVHYQLLVTWAKHFTLEVNSVVIRVEAEQAHPCTVVSVQDIVCPVYDLDHNVEFIGVYQSMTKQAAITVQRKDFPDGKFYIVFVVRPEDYACGGSFTTEEGANMVAAFHPIDSSGTEEGGYGAIEESSCRTPASHSSTPQDTARCRSYSDSSAEEDSDFDPVHNFDMNKDVARTKTFLYVSDLARKDSKSIRKKYQVYFCAFNNILSNAGYIMLGFLFLLIVLQRDMTYRRALEVKDIYATECGIPKHFGLFYAMAVALMMEGVLSACYHVCPNYSNFQFDTSFLYMIAGLCMLKLYQTRHPDINPRAYAVYAIFALVIFLAVLGVIFGKNATWFWILFSAVHVIASLALSTHIYYMGRLKIDVGVFKRIALVLYTDFIQQCNGPQYMCEIKAPFSHSAIFGLILRPKDFASYLLGIFICNLLLYLAFYIIMKLRSLEKIRPIPSFCIIATAVLWAAALYFFFQNLTSWERAQKKGDIILGGLFPIHFGVAAKDQDLSSRPESTECVRYNFRGFRWLQAMIFAIEEINNSSTLLPNITLGYRIFDTCNTVSKALEATLSFVAQNKIDSLNLDEFCNCSDHIPSTIAVVGATGSGISTAVANLLGLFYIPQVSYASSSRLLSNKNQYKSFLRTIPTDEYQATAMADIMDHFHWNWVITVAADDDYGRPGIEKFEQEVQERDICIDFSILISQYSDEKYIQETVDRIKNSSAKVIAVFSSGPDLEPLIKEIVRRNITDRIWLASEAWASSSLIAKQEFFHVVGGTIGFALRAGQIPGFRQFLQQVNPKKSPHNGFVREFWEETFSCYLRDSSDYKTAGLMNRRNSEVPQSGNVSAGFRAPCTGEENITSVETPYLDYTHLRISYNVYVAVYSIAHALQDILTCTPGKGLFINGSCADIKKVEAWQVLKQLRHLNFTNNMGEQVDFDESGDLLGNYTIINWHHNPEDGSVMFEEVGHYNMNAKSGERLYIDESKILWNGFLREVPFSNCSKDCDPGTRKGIIEGEPTCCFECVACPDGEYTDERDASECIKCSEDSWSNENHTSCILKQIEFLSWTEPFGIALTLFAALGIFLTSFVLGVFVKFRNTPIVKATNRELSYLLLFSLICCFSSSLIFIGEPQDWTCQLRQPAFGISFVLCISCILVKTNRVLLVFEAKIPTSLHRKWWGLNLQFLLVFLCTFVQIMTCGIWLYNSPPKSYRNHEMDDEIIFVTCNEGSLMALGFLIGYTCLLAAICFFFAFKSRKLPENFNEAKFITFSMLIFFIVWISFIPAYVSTHGKFVSAVEVIAILASSFGLLACIFFNKIYIILFKPSRNTIEEVRCSTAAHAFKVAARATLRRSTVSQKRSNSIDSSSVSTPNSSICSKTNSEEQSPPGGKQRECKQKVSFGSGTVTLSLSFEEAKRNSTGCKHMKRRNSLEAKASDDSLMRQKALLPLQNSEAGSEISFRTASISPSQESVSETCNSMDTAPFSSGNSIYPSSNAVPETSNTS

Features

Showing features for non-terminal residue, compositional bias.

Type
IDPosition(s)Description
Non-terminal residue1
Compositional bias274-292Polar residues
Compositional bias1483-1515Polar residues
Non-terminal residue1631

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JAATIS010008602
EMBL· GenBank· DDBJ
KAG2456461.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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