A0A8X7X4B9 · A0A8X7X4B9_POLSE
- ProteinGuanylate cyclase
- GeneVit_2
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids2869 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
Catalytic activity
- GTP = 3',5'-cyclic GMP + diphosphate
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | membrane | |
Molecular Function | ATP binding | |
Molecular Function | guanylate cyclase activity | |
Molecular Function | lipid transporter activity | |
Molecular Function | nutrient reservoir activity | |
Molecular Function | protein kinase activity | |
Biological Process | cellular response to estrogen stimulus | |
Biological Process | intracellular signal transduction | |
Biological Process | response to estradiol | |
Biological Process | visual perception |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameGuanylate cyclase
- EC number
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Polypteriformes > Polypteridae > Polypterus
Accessions
- Primary accessionA0A8X7X4B9
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Photoreceptor outer segment membrane ; Single-pass type I membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 270-292 | Helical | ||||
Sequence: LAIGLPVAVFFTGFILTMVWFQY |
Keywords
- Cellular component
PTM/Processing
Features
Showing features for disulfide bond.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Disulfide bond | 1414↔1440 | |||||
Sequence: CQTSYVIQEEQKGNHIIVTKSKDLNNC | ||||||
Disulfide bond | 1456↔1459 | |||||
Sequence: CAYC |
Keywords
- PTM
Structure
Family & Domains
Features
Showing features for region, compositional bias, domain, coiled coil.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 24-52 | Disordered | ||||
Sequence: ENKKPRLQKQHEVERVKEKNEGSSRSQQF | ||||||
Compositional bias | 27-47 | Basic and acidic residues | ||||
Sequence: KPRLQKQHEVERVKEKNEGSS | ||||||
Domain | 313-611 | Protein kinase | ||||
Sequence: GKIDDDVGFGSITSLQKLNNLSNTSHVTDITVKTDKSTSPVQSCLEVGVYDGRSVAIRRLQKKHFTLSKSIRKEVKEVRELDHPNLCKFIGGSIEVPNVAIVTEYCPKGSLTDVLLNEEVPLNWGFRLSFATDIARAMAYLHQHKMFHGRLHSKNCVIDDRWVCKISDYGLANYRKEDFEKSGSIFSRKFSRLYCAPEVLLGSSSNITPAADIYSFSIILVEIATRSDLVSGDVDPVKTDITWRPPLPDFKLAKTDNYCPNEADYCELVKKCWNHSAPMRPTFEQIKKMLEKMNPHKVS | ||||||
Domain | 673-803 | Guanylate cyclase | ||||
Sequence: SSATVDIVGFTQLSSASTPHEVVDFLNKLYTTFDDIIDNYDVYKVETIGDAYMVVSGVPKVNGINHAGEIASMALGLVNVCETFKIPHKPNTQLKIRAGIHSGPVVSGVVGTKMPRYCLFGDTVNTASRME | ||||||
Coiled coil | 918-945 | |||||
Sequence: ASQYNHDMKRKEREFSKVKERLNQILID | ||||||
Coiled coil | 987-1014 | |||||
Sequence: LGDYEHRLKDLMIENAELKKVLQQMKKE | ||||||
Compositional bias | 1020-1036 | Basic and acidic residues | ||||
Sequence: HPQKHEFKEKKEESIDP | ||||||
Region | 1020-1050 | Disordered | ||||
Sequence: HPQKHEFKEKKEESIDPVASDDEEEPGENSK | ||||||
Domain | 1275-1895 | Vitellogenin | ||||
Sequence: LIPNKSSPEIQPKRSSLQDPNARLYGDDYVENVQSVMSSPPHYKGLQHSIIDPEIKEYNGNWPKDQFSPAEKLTQALASQLQRPIKFEYYNGRVGNIFAAEDIAETVINIQRGILNLLQVNIKKTQNVYELQEAGIGGVCQTSYVIQEEQKGNHIIVTKSKDLNNCEDRVKKDIGMAYMEHCAYCQQRGKNLRGAAAYTYILKPSDTGALITEANAQEIHQYTPFNERSGAAQMEARQKLILVNVKNNPVRAVDIQLERRGNLQYEFASEVLQTPIQLFRAKNPETEIVETLHHLVQNNQKEVHADAPAKFLQLTQLLRTASHPNFEAIWKQFENRRDYRRWILDAIPAVGNAYALRFFKEKIQENVLTTAEAAQALVTLMHLTKADHDTMPLAAALVHSHHVQQSPVLRKIAFLGYGTLVYKYCSARQNCPENFLQPLHDFAADAASKAHEEEIVLALKALGNAGQPASIKRIQKFLPGFSSSASHFPVKVQEIAAQLFMDKDLHHEVRIMSCIVLFEAKPPVALVATISDALLKETSLQLASFAYSHMKSLSRSSVPDYYPVAASVNVAIKLLSPKLDRLSYRYSKAIRMDTFKTEWMTGMAANAFIINSPNNVIPAAV | ||||||
Region | 2320-2395 | Disordered | ||||
Sequence: TDESAPKNLTQRSSSSSSSPSSSSSQSNSSSSSSSSSQQNDDRKQNLNVKSRRRSSRSSSSSSSSSSSSSSSSSSS | ||||||
Compositional bias | 2323-2363 | Polar residues | ||||
Sequence: SAPKNLTQRSSSSSSSPSSSSSQSNSSSSSSSSSQQNDDRK | ||||||
Compositional bias | 2371-2395 | Polar residues | ||||
Sequence: RRRSSRSSSSSSSSSSSSSSSSSSS | ||||||
Domain | 2607-2779 | VWFD | ||||
Sequence: GHCTLNRSKINTFNNAEFDAKLPDSCEVILAQDCTENLQYAVLYRKMDSLKRKMLRVVVANKNVQLSHSGESVNIQMNGQNVPSLPYSDRGVSVRRENNGVILEASEHGLKEVYFDKNQIKIQVASLKKGETCGLCGKGDGETRREYTMPSGRLTTCPSAFTQSWTITEETCD |
Sequence similarities
Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusFragment
- Length2,869
- Mass (Da)321,982
- Last updated2022-12-14 v1
- Checksum04A5D55F8968EA81
Features
Showing features for non-terminal residue, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Non-terminal residue | 1 | |||||
Sequence: M | ||||||
Compositional bias | 27-47 | Basic and acidic residues | ||||
Sequence: KPRLQKQHEVERVKEKNEGSS | ||||||
Compositional bias | 1020-1036 | Basic and acidic residues | ||||
Sequence: HPQKHEFKEKKEESIDP | ||||||
Compositional bias | 2323-2363 | Polar residues | ||||
Sequence: SAPKNLTQRSSSSSSSPSSSSSQSNSSSSSSSSSQQNDDRK | ||||||
Compositional bias | 2371-2395 | Polar residues | ||||
Sequence: RRRSSRSSSSSSSSSSSSSSSSSSS | ||||||
Non-terminal residue | 2869 | |||||
Sequence: S |
Keywords
- Technical term