A0A8X7NTX4 · A0A8X7NTX4_CANPA
- ProteinDelta-aminolevulinic acid dehydratase
- GeneHEM2
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids341 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen.
Catalytic activity
- 2 5-aminolevulinate = porphobilinogen + 2 H2O + H+
Pathway
Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 1/4.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 134 | Zn2+ (UniProtKB | ChEBI); catalytic | |||
Binding site | 136 | Zn2+ (UniProtKB | ChEBI); catalytic | |||
Binding site | 144 | Zn2+ (UniProtKB | ChEBI); catalytic | |||
Active site | 211 | Schiff-base intermediate with substrate | |||
Binding site | 221 | 5-aminolevulinate 1 (UniProtKB | ChEBI) | |||
Binding site | 233 | 5-aminolevulinate 1 (UniProtKB | ChEBI) | |||
Active site | 264 | Schiff-base intermediate with substrate | |||
Binding site | 291 | 5-aminolevulinate 2 (UniProtKB | ChEBI) | |||
Binding site | 330 | 5-aminolevulinate 2 (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Molecular Function | porphobilinogen synthase activity | |
Molecular Function | zinc ion binding | |
Biological Process | heme biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameDelta-aminolevulinic acid dehydratase
- EC number
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Fungi > Dikarya > Ascomycota > Saccharomycotina > Saccharomycetes > Saccharomycetales > Debaryomycetaceae > Candida/Lodderomyces clade > Candida
Accessions
- Primary accessionA0A8X7NTX4
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Interaction
Subunit
Homooctamer.
Structure
Sequence
- Sequence statusComplete
- Length341
- Mass (Da)37,384
- Last updated2022-12-14 v1
- Checksum789838C084AC239D
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
JABWAB010000001 EMBL· GenBank· DDBJ | KAF6059593.1 EMBL· GenBank· DDBJ | Genomic DNA |