A0A8X7NTX4 · A0A8X7NTX4_CANPA

Function

function

Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen.

Catalytic activity

Pathway

Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 1/4.

Features

Showing features for binding site, active site.

134150100150200250300
Type
IDPosition(s)Description
Binding site134Zn2+ (UniProtKB | ChEBI); catalytic
Binding site136Zn2+ (UniProtKB | ChEBI); catalytic
Binding site144Zn2+ (UniProtKB | ChEBI); catalytic
Active site211Schiff-base intermediate with substrate
Binding site2215-aminolevulinate 1 (UniProtKB | ChEBI)
Binding site2335-aminolevulinate 1 (UniProtKB | ChEBI)
Active site264Schiff-base intermediate with substrate
Binding site2915-aminolevulinate 2 (UniProtKB | ChEBI)
Binding site3305-aminolevulinate 2 (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Functionporphobilinogen synthase activity
Molecular Functionzinc ion binding
Biological Processheme biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Delta-aminolevulinic acid dehydratase
  • EC number

Gene names

    • Name
      HEM2
    • ORF names
      FOB60_001175

Organism names

  • Taxonomic identifier
  • Strain
    • FDAARGOS_652
  • Taxonomic lineage
    Eukaryota > Fungi > Dikarya > Ascomycota > Saccharomycotina > Saccharomycetes > Saccharomycetales > Debaryomycetaceae > Candida/Lodderomyces clade > Candida

Accessions

  • Primary accession
    A0A8X7NTX4

Proteomes

Subcellular Location

Interaction

Subunit

Homooctamer.

Family & Domains

Sequence similarities

Belongs to the ALAD family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    341
  • Mass (Da)
    37,384
  • Last updated
    2022-12-14 v1
  • Checksum
    789838C084AC239D
MVHKAEFLETTEYSVKSVLQGGYNHPLSREWQQERQLTKNMFIFPLFVTDDPDEESEIPSLPNIKRYGVNKLIPYVGSLVEKGLRAVILFGVPLKPGVKDEFGTAADDPEGPVITSIKLLKENFPDLFIMCDVCLCEYTSHGHCGILNDDGSLKPEPSVKRIAAVAVNYAKAGANCVAPSDMMDGRIKDIKMGLIKAGLANKCLVMSYAAKFSGNLYGPFRDAAGSAPSHGDRKAYQLPPAGSGLARRALLRDMEEGADAVIVKPSTFYLDIISDASRVCRDYPICAYHVSGEYAMLHAAAEKGIVDLKGIAFEAHQGFLRAGARLIISYFTPEFLEWLQV

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JABWAB010000001
EMBL· GenBank· DDBJ
KAF6059593.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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