A0A8X7NR02 · A0A8X7NR02_CANPA

Function

function

Catalyzes the first intracellular reaction of sulfate assimilation, forming adenosine-5'-phosphosulfate (APS) from inorganic sulfate and ATP. Plays an important role in sulfate activation as a component of the biosynthesis pathway of sulfur-containing amino acids.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Catalytic activity

Pathway

Sulfur metabolism; hydrogen sulfide biosynthesis; sulfite from sulfate: step 1/3.

Features

Showing features for binding site, active site, site.

152250100150200250300350400450500
Type
IDPosition(s)Description
Binding site205sulfate (UniProtKB | ChEBI)
Binding site205-208ATP (UniProtKB | ChEBI)
Active site206
Active site207
Binding site207sulfate (UniProtKB | ChEBI)
Active site208
Site211Transition state stabilizer
Site214Transition state stabilizer
Binding site301-304ATP (UniProtKB | ChEBI)
Binding site305sulfate (UniProtKB | ChEBI)
Site340Induces change in substrate recognition on ATP binding
Binding site343ATP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular FunctionATP binding
Molecular Functionsulfate adenylyltransferase (ATP) activity
Biological Processcysteine biosynthetic process
Biological Processmethionine biosynthetic process
Biological Processsulfate assimilation via adenylyl sulfate reduction
Biological Processsulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin)

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Sulfate adenylyltransferase
  • EC number
  • Alternative names
    • ATP-sulfurylase
    • Sulfate adenylate transferase
      (SAT
      )

Gene names

    • Name
      MET3
    • ORF names
      FOB60_000349

Organism names

  • Taxonomic identifier
  • Strain
    • FDAARGOS_652
  • Taxonomic lineage
    Eukaryota > Fungi > Dikarya > Ascomycota > Saccharomycotina > Saccharomycetes > Saccharomycetales > Debaryomycetaceae > Candida/Lodderomyces clade > Candida

Accessions

  • Primary accession
    A0A8X7NR02

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Homohexamer. Dimer of trimers.

Family & Domains

Features

Showing features for region, domain.

Type
IDPosition(s)Description
Region1-175N-terminal
Domain5-170ATP-sulfurylase PUA-like
Domain180-398Sulphate adenylyltransferase catalytic
Region406-522Required for oligomerization; adenylyl-sulfate kinase-like

Domain

The oligomerization domain is distantly related to APS kinases, but it is not functional and does not bind APS. It is required for oligomerization of the enzyme, although the oligomerization state has no effect on the catalytic activity of the enzyme.

Sequence similarities

Belongs to the sulfate adenylyltransferase family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    522
  • Mass (Da)
    58,883
  • Last updated
    2022-12-14 v1
  • Checksum
    055E0D0FF0AA6471
MPIPKPHGGQLNDLIIRDVEKKPQLLKEVEKLPHLTLTPRQLCDLELILNGGFSPLTGFLNEDDYNSVVEDLRLTSVKNDQGKGLIWPIPITLDVSQQTAQQYKIGDRVALLDLRDETPLAILTIESIYIPDKQKEAKLVFRGDPEHPANKYLFETAGDVYIGGSLEGINYPKHYDYVDARKTPTELRNEFNSLGWTNQNIVAFQTRNPMHRAHRELTIRAANDIGSNAHILIHPVVGLTKPGDIDHHTRVKVYKQILQKFPEGLASLSLLPLAMRMGGDREALWHALIRTNYGVDHFIVGRDHAGPGKNSQGVDFYGPYDAQELLQKYQDELDIKIVPFRMVTYLPDEDRYAPIDTIDTTKVKTANISGTELRNKLRTGDAIPEWFSYPEVVKILRETNPPRFKQGFVIIIETESKLGQYLSFALQSTLNQFSGERRITKIDQQEHNVEPFIINELVKSGTGVILTTENTHTDKIAQLAGEGNSIIVGSNSDASKGQFKLNEDLNVTIDEIVSFLQQQGFY

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JABWAB010000001
EMBL· GenBank· DDBJ
KAF6058767.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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