A0A8X6NRT1 · A0A8X6NRT1_NEPPI
- ProteinMethylcytosine dioxygenase TET
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids289 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
function
Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in epigenetic chromatin reprogramming during embryonic development.
Catalytic activity
- a 5-formyl-2'-deoxycytidine in DNA + 2-oxoglutarate + O2 = a 5-carboxyl-2'-deoxycytidine in DNA + succinate + CO2 + H+
Cofactor
Protein has several cofactor binding sites:
Note: Binds 1 Fe2+ ion per subunit.
Note: The zinc ions have a structural role.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | nucleus | |
Molecular Function | 5-methylcytosine dioxygenase activity | |
Molecular Function | zinc ion binding | |
Biological Process | 5-methylcytosine catabolic process | |
Biological Process | chromosomal 5-methylcytosine DNA demethylation pathway | |
Biological Process | positive regulation of transcription by RNA polymerase II |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameMethylcytosine dioxygenase TET
- EC number
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Arthropoda > Chelicerata > Arachnida > Araneae > Araneomorphae > Entelegynae > Araneoidea > Nephilidae > Nephila
Accessions
- Primary accessionA0A8X6NRT1
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 1-286 | Methylcytosine dioxygenase TET1-3 oxygenase | |||
Sequence similarities
Belongs to the TET family.
Family and domain databases
Sequence
- Sequence statusFragment
- Length289
- Mass (Da)32,199
- Last updated2022-12-14 v1
- MD5 ChecksumD9479789D6759620EDFA0D563D683528
Features
Showing features for non-terminal residue.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Non-terminal residue | 1 | ||||
Non-terminal residue | 289 | ||||
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
BMAW01005713 EMBL· GenBank· DDBJ | GFS95675.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BMAW01012315 EMBL· GenBank· DDBJ | GFT27990.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BMAW01111062 EMBL· GenBank· DDBJ | GFT46086.1 EMBL· GenBank· DDBJ | Genomic DNA |