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A0A8X6NRT1 · A0A8X6NRT1_NEPPI

Function

function

Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in epigenetic chromatin reprogramming during embryonic development.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
Fe2+ (UniProtKB | Rhea| CHEBI:29033 )

Note: Binds 1 Fe2+ ion per subunit.
Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: The zinc ions have a structural role.

GO annotations

AspectTerm
Cellular Componentnucleus
Molecular Function5-methylcytosine dioxygenase activity
Molecular Functionzinc ion binding
Biological Process5-methylcytosine catabolic process
Biological Processchromosomal 5-methylcytosine DNA demethylation pathway
Biological Processpositive regulation of transcription by RNA polymerase II

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Methylcytosine dioxygenase TET
  • EC number

Gene names

    • ORF names
      NPIL_147841
      , NPIL_298281
      , NPIL_478671

Organism names

Accessions

  • Primary accession
    A0A8X6NRT1

Proteomes

Subcellular Location

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-286Methylcytosine dioxygenase TET1-3 oxygenase

Sequence similarities

Belongs to the TET family.

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    289
  • Mass (Da)
    32,199
  • Last updated
    2022-12-14 v1
  • MD5 Checksum
    D9479789D6759620EDFA0D563D683528
VVTLTKHKGWEKPEDEQLHVLPLYVMDSTDECGSKESQDKKIASGALEVLKKFPIDFKIRTTPLKPCKTRGRKPKDGFSPRKQALQTAFKQLIASGKLRRIEPPEVYQKCHAGNNRLFPMPTHHQNNSQSNNKDFMNSQQIFSNGYGSSVQSNVLMPSNSYKREETACKFYAGKHISHNSYSTTLNQVWMSQSQHDFNSASSVRNSQNPSANTMQGGCYHNSSSFSSNDASFSSNNNSSFSSNNNSFSSNNNLSFSSNNNSFSSNNNNSFSSNNNNSFSSNNNNSFSSN

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue1
Non-terminal residue289

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
BMAW01005713
EMBL· GenBank· DDBJ
GFS95675.1
EMBL· GenBank· DDBJ
Genomic DNA
BMAW01012315
EMBL· GenBank· DDBJ
GFT27990.1
EMBL· GenBank· DDBJ
Genomic DNA
BMAW01111062
EMBL· GenBank· DDBJ
GFT46086.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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