A0A8W6ANL8 · A0A8W6ANL8_HUMAN
- ProteinInterleukin-2 receptor subunit beta
- GeneIL2RB
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids322 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | membrane | |
Molecular Function | cytokine receptor activity |
Keywords
- Molecular function
Names & Taxonomy
Protein names
- Recommended nameInterleukin-2 receptor subunit beta
- Alternative names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionA0A8W6ANL8
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Membrane ; Single-pass type I membrane protein
Keywords
- Cellular component
Disease & Variants
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 302 variants from UniProt as well as other sources including ClinVar and dbSNP.
Genetic variation databases
PTM/Processing
Interaction
Subunit
Non-covalent dimer of an alpha and a beta subunit. IL2R exists in 3 different forms: a high affinity dimer, an intermediate affinity monomer (beta subunit), and a low affinity monomer (alpha subunit). The high and intermediate affinity forms also associate with a gamma subunit. Interacts with SHB upon interleukin stimulation.
Sequence
- Sequence statusComplete
- Length322
- Mass (Da)36,331
- Last updated2022-12-14 v1
- Checksum2D0FB59E8D0B0EEC
Computationally mapped potential isoform sequences
There are 13 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
P14784 | IL2RB_HUMAN | IL2RB | 551 | ||
B0QYC0 | B0QYC0_HUMAN | IL2RB | 188 | ||
B0QYC1 | B0QYC1_HUMAN | IL2RB | 146 | ||
B0QYC2 | B0QYC2_HUMAN | IL2RB | 88 | ||
H7C1H9 | H7C1H9_HUMAN | IL2RB | 139 | ||
A0A8V8TNU9 | A0A8V8TNU9_HUMAN | IL2RB | 85 | ||
A0A8V8TNV4 | A0A8V8TNV4_HUMAN | IL2RB | 272 | ||
A0A8V8TP57 | A0A8V8TP57_HUMAN | IL2RB | 35 | ||
A0A8V8TP62 | A0A8V8TP62_HUMAN | IL2RB | 550 | ||
A0A8V8TMD3 | A0A8V8TMD3_HUMAN | IL2RB | 557 | ||
A0A8V8TMD8 | A0A8V8TMD8_HUMAN | IL2RB | 550 | ||
A0A8V8TMF2 | A0A8V8TMF2_HUMAN | IL2RB | 82 | ||
A0A8V8TMF6 | A0A8V8TMF6_HUMAN | IL2RB | 542 |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AL022314 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
KF457432 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
KF457436 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
Z82188 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. |