A0A8V8TQH4 · A0A8V8TQH4_HUMAN
- Protein5'-3' exonuclease PLD3
- GenePLD3
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids346 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score3/5
Function
Catalytic activity
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | early endosome membrane | |
Cellular Component | endoplasmic reticulum membrane | |
Cellular Component | Golgi membrane | |
Cellular Component | late endosome membrane | |
Cellular Component | lysosomal lumen | |
Molecular Function | nuclease activity |
Keywords
- Molecular function
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended name5'-3' exonuclease PLD3
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionA0A8V8TQH4
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Early endosome membrane ; Single-pass type II membrane protein
Endoplasmic reticulum membrane ; Single-pass type II membrane protein
Endosome membrane ; Single-pass type II membrane protein
Golgi apparatus membrane ; Single-pass type II membrane protein
Late endosome membrane ; Single-pass type II membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 38-60 | Helical | ||||
Sequence: WVLLVLILAVVGFGALMTQLFLW |
Keywords
- Cellular component
Disease & Variants
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 350 variants from UniProt as well as other sources including ClinVar and dbSNP.
Genetic variation databases
PTM/Processing
Proteomic databases
Interaction
Subunit
Interacts with APP.
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 196-223 | PLD phosphodiesterase | ||||
Sequence: THGVLHTKFWVVDQTHFYLGSANMDWRS |
Sequence similarities
Belongs to the phospholipase D family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length346
- Mass (Da)38,757
- Last updated2022-12-14 v1
- Checksum2A9BF285F3E6BE93
Computationally mapped potential isoform sequences
There are 15 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
Q8IV08 | PLD3_HUMAN | PLD3 | 490 | ||
M0R1F7 | M0R1F7_HUMAN | PLD3 | 213 | ||
M0R3G9 | M0R3G9_HUMAN | PLD3 | 71 | ||
M0R2W7 | M0R2W7_HUMAN | PLD3 | 111 | ||
M0R2E7 | M0R2E7_HUMAN | PLD3 | 44 | ||
A0A0A0MS28 | A0A0A0MS28_HUMAN | PLD3 | 128 | ||
M0QY94 | M0QY94_HUMAN | PLD3 | 70 | ||
M0QX50 | M0QX50_HUMAN | PLD3 | 81 | ||
M0QX99 | M0QX99_HUMAN | PLD3 | 119 | ||
M0QZK2 | M0QZK2_HUMAN | PLD3 | 28 | ||
M0QYJ4 | M0QYJ4_HUMAN | PLD3 | 121 | ||
A0A8V8TRD4 | A0A8V8TRD4_HUMAN | PLD3 | 507 | ||
A0A8V8TPY8 | A0A8V8TPY8_HUMAN | PLD3 | 468 | ||
A0A8V8TQH6 | A0A8V8TQH6_HUMAN | PLD3 | 464 | ||
E2QRG1 | E2QRG1_HUMAN | PLD3 | 177 |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AC010271 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AC118344 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. |