A0A8V8TP61 · A0A8V8TP61_HUMAN

  • Protein
    PMS1 homolog 2, mismatch repair system component
  • Gene
    PMS2
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    2/5

Function

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentmismatch repair complex
Cellular Componentnucleus
Molecular FunctionATP binding
Molecular FunctionATP hydrolysis activity
Molecular FunctionATP-dependent DNA damage sensor activity
Molecular Functionmismatched DNA binding
Biological Processmismatch repair

Keywords

Names & Taxonomy

Protein names

  • Submitted names
    • PMS1 homolog 2, mismatch repair system component

Gene names

    • Name
      PMS2

Organism names

  • Taxonomic identifier
  • Organism
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    A0A8V8TP61

Proteomes

Organism-specific databases

Subcellular Location

Keywords

  • Cellular component

Disease & Variants

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 3,202 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Genetic variation databases

PTM/Processing

Features

Showing features for modified residue (large scale data).

TypeIDPosition(s)SourceDescription
Modified residue (large scale data)85PRIDEPhosphoserine
Modified residue (large scale data)216PRIDEPhosphoserine
Modified residue (large scale data)218PRIDEPhosphoserine
Modified residue (large scale data)249PRIDEPhosphoserine
Modified residue (large scale data)252PRIDEPhosphothreonine
Modified residue (large scale data)258PRIDEPhosphoserine
Modified residue (large scale data)348PRIDEPhosphoserine
Modified residue (large scale data)386PRIDEPhosphothreonine
Modified residue (large scale data)401PRIDEPhosphoserine
Modified residue (large scale data)410PRIDEPhosphothreonine
Modified residue (large scale data)416PRIDEPhosphoserine

Proteomic databases

Structure

3D structure databases

Family & Domains

Features

Showing features for domain, compositional bias, region.

TypeIDPosition(s)Description
Domain92-238DNA mismatch repair protein S5
Compositional bias208-253Basic and acidic residues
Region208-365Disordered
Compositional bias263-277Polar residues
Compositional bias297-311Basic and acidic residues
Compositional bias312-337Polar residues
Compositional bias343-365Basic and acidic residues
Domain491-635MutL C-terminal dimerisation

Sequence similarities

Belongs to the DNA mismatch repair MutL/HexB family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    675
  • Mass (Da)
    75,484
  • Last updated
    2022-12-14 v1
  • Checksum
    B0B31A3BB4B0CC33
MFDHNGKIIQKTPYPRPRGTTVSVQQLFSTLPVRHKEFQRNIKKEYAKMVQVLHAYCIISAGIRVSCTNQLGQGKRQPVVCTGGSPSIKENIGSVFGQKQLQSLIPFVQLPPSDSVCEEYGLSCSDALHNLFYISGFISQCTHGVGRSSTDRQFFFINRRPCDPAKVCRLVNEVYHMYNRHQYPFVVLNISVDSGNLIKMHAADLEKPMVEKQDQSPSLRTGEEKKDVSISRLREAFSLRHTTENKPHSPKTPEPRRSPLGQKRGMLSSSTSGAISDKGVLRPQKEAVSSSHGPSDPTDRAEVEKDSGHGSTSVDSEGFSIPDTGSHCSSEYAASSPGDRGSQEHVDSQEKAPKTDDSFSDVDCHSNQEDTGCKFRVLPQPTNLATPNTKRFKKEEILSSSDICQKLVNTQDMSASQVDVAVKINKKVVPLDFSMSSLAKRIKQLHHEAQQSEGEQNYRKFRAKICPGENQAAEDELRKEISKTMFAEMEIIGQFNLGFIITKLNEDIFIVDQHATDEKYNFEMLQQHTVLQGQRLIAPQTLNLTAVNEAVLIENLEIFRKNGFDFVIDENAPVTERAKLISLPTSKNWTFGPQDVDELIFMLSDSPGVMCRPSRVKQMFASRACRKSVMIGTALNTSEMKKLITHMGEMDHPWNCPHGRPTMRHIANLGVISQN

Computationally mapped potential isoform sequences

There are 36 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
P54278PMS2_HUMANPMS2862
C9J167C9J167_HUMANPMS2756
A0A2R8Y6S3A0A2R8Y6S3_HUMANPMS2727
A0A8V8TQG9A0A8V8TQG9_HUMANPMS2810
A0A8V8TQH3A0A8V8TQH3_HUMANPMS263
A0A8V8TQH7A0A8V8TQH7_HUMANPMS2208
A0A8V8TQI1A0A8V8TQI1_HUMANPMS2814
A0A8V8TQM5A0A8V8TQM5_HUMANPMS2343
A0A8V8TQN0A0A8V8TQN0_HUMANPMS288
A0A8V8TQR6A0A8V8TQR6_HUMANPMS296
A0A8V8TQS5A0A8V8TQS5_HUMANPMS2826
A0A8V8TQT4A0A8V8TQT4_HUMANPMS2267
A0A8V8TP84A0A8V8TP84_HUMANPMS2671
A0A8V8TP89A0A8V8TP89_HUMANPMS2771
A0A8V8TPD1A0A8V8TPD1_HUMANPMS271
A0A8V8TPE1A0A8V8TPE1_HUMANPMS2806
A0A8V8TPE7A0A8V8TPE7_HUMANPMS2264
A0A8V8TPJ6A0A8V8TPJ6_HUMANPMS2207
A0A8V8TPK2A0A8V8TPK2_HUMANPMS2347
A0A8V8TQ41A0A8V8TQ41_HUMANPMS248
A0A8V8TQ50A0A8V8TQ50_HUMANPMS2873
A0A8V8TQ88A0A8V8TQ88_HUMANPMS2247
A0A8V8TQ92A0A8V8TQ92_HUMANPMS2738
A0A8V8TNV6A0A8V8TNV6_HUMANPMS2100
A0A8V8TNW1A0A8V8TNW1_HUMANPMS291
A0A8V8TNX1A0A8V8TNX1_HUMANPMS272
A0A8V8TNX6A0A8V8TNX6_HUMANPMS2924
A0A8V8TNY8A0A8V8TNY8_HUMANPMS2796
A0A8V8TNZ8A0A8V8TNZ8_HUMANPMS2161
A0A8V8TP55A0A8V8TP55_HUMANPMS2399
A0A8V8TP66A0A8V8TP66_HUMANPMS2182
A0A8V8TP72A0A8V8TP72_HUMANPMS2861
A0A8V8TP79A0A8V8TP79_HUMANPMS2119
A0A8V8TNQ7A0A8V8TNQ7_HUMANPMS247
A0A8V8TNR3A0A8V8TNR3_HUMANPMS2151
A0A8V8TNR7A0A8V8TNR7_HUMANPMS2530

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias208-253Basic and acidic residues
Compositional bias263-277Polar residues
Compositional bias297-311Basic and acidic residues
Compositional bias312-337Polar residues
Compositional bias343-365Basic and acidic residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AC005995
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.

Genome annotation databases

Similar Proteins

Disclaimer

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