A0A8V8TP61 · A0A8V8TP61_HUMAN
- ProteinPMS1 homolog 2, mismatch repair system component
- GenePMS2
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids675 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score2/5
Function
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | mismatch repair complex | |
Cellular Component | nucleus | |
Molecular Function | ATP binding | |
Molecular Function | ATP hydrolysis activity | |
Molecular Function | ATP-dependent DNA damage sensor activity | |
Molecular Function | mismatched DNA binding | |
Biological Process | mismatch repair |
Keywords
- Biological process
Names & Taxonomy
Protein names
- Submitted names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionA0A8V8TP61
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Keywords
- Cellular component
Disease & Variants
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 3,202 variants from UniProt as well as other sources including ClinVar and dbSNP.
Genetic variation databases
PTM/Processing
Features
Showing features for modified residue (large scale data).
Type | ID | Position(s) | Source | Description | |||
---|---|---|---|---|---|---|---|
Modified residue (large scale data) | 85 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 216 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 218 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 249 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 252 | PRIDE | Phosphothreonine | ||||
Sequence: T | |||||||
Modified residue (large scale data) | 258 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 348 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 386 | PRIDE | Phosphothreonine | ||||
Sequence: T | |||||||
Modified residue (large scale data) | 401 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 410 | PRIDE | Phosphothreonine | ||||
Sequence: T | |||||||
Modified residue (large scale data) | 416 | PRIDE | Phosphoserine | ||||
Sequence: S |
Proteomic databases
Family & Domains
Features
Showing features for domain, compositional bias, region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 92-238 | DNA mismatch repair protein S5 | ||||
Sequence: IGSVFGQKQLQSLIPFVQLPPSDSVCEEYGLSCSDALHNLFYISGFISQCTHGVGRSSTDRQFFFINRRPCDPAKVCRLVNEVYHMYNRHQYPFVVLNISVDSGNLIKMHAADLEKPMVEKQDQSPSLRTGEEKKDVSISRLREAFS | ||||||
Compositional bias | 208-253 | Basic and acidic residues | ||||
Sequence: PMVEKQDQSPSLRTGEEKKDVSISRLREAFSLRHTTENKPHSPKTP | ||||||
Region | 208-365 | Disordered | ||||
Sequence: PMVEKQDQSPSLRTGEEKKDVSISRLREAFSLRHTTENKPHSPKTPEPRRSPLGQKRGMLSSSTSGAISDKGVLRPQKEAVSSSHGPSDPTDRAEVEKDSGHGSTSVDSEGFSIPDTGSHCSSEYAASSPGDRGSQEHVDSQEKAPKTDDSFSDVDCH | ||||||
Compositional bias | 263-277 | Polar residues | ||||
Sequence: KRGMLSSSTSGAISD | ||||||
Compositional bias | 297-311 | Basic and acidic residues | ||||
Sequence: PTDRAEVEKDSGHGS | ||||||
Compositional bias | 312-337 | Polar residues | ||||
Sequence: TSVDSEGFSIPDTGSHCSSEYAASSP | ||||||
Compositional bias | 343-365 | Basic and acidic residues | ||||
Sequence: QEHVDSQEKAPKTDDSFSDVDCH | ||||||
Domain | 491-635 | MutL C-terminal dimerisation | ||||
Sequence: IIGQFNLGFIITKLNEDIFIVDQHATDEKYNFEMLQQHTVLQGQRLIAPQTLNLTAVNEAVLIENLEIFRKNGFDFVIDENAPVTERAKLISLPTSKNWTFGPQDVDELIFMLSDSPGVMCRPSRVKQMFASRACRKSVMIGTAL |
Sequence similarities
Belongs to the DNA mismatch repair MutL/HexB family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length675
- Mass (Da)75,484
- Last updated2022-12-14 v1
- ChecksumB0B31A3BB4B0CC33
Computationally mapped potential isoform sequences
There are 36 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
P54278 | PMS2_HUMAN | PMS2 | 862 | ||
C9J167 | C9J167_HUMAN | PMS2 | 756 | ||
A0A2R8Y6S3 | A0A2R8Y6S3_HUMAN | PMS2 | 727 | ||
A0A8V8TQG9 | A0A8V8TQG9_HUMAN | PMS2 | 810 | ||
A0A8V8TQH3 | A0A8V8TQH3_HUMAN | PMS2 | 63 | ||
A0A8V8TQH7 | A0A8V8TQH7_HUMAN | PMS2 | 208 | ||
A0A8V8TQI1 | A0A8V8TQI1_HUMAN | PMS2 | 814 | ||
A0A8V8TQM5 | A0A8V8TQM5_HUMAN | PMS2 | 343 | ||
A0A8V8TQN0 | A0A8V8TQN0_HUMAN | PMS2 | 88 | ||
A0A8V8TQR6 | A0A8V8TQR6_HUMAN | PMS2 | 96 | ||
A0A8V8TQS5 | A0A8V8TQS5_HUMAN | PMS2 | 826 | ||
A0A8V8TQT4 | A0A8V8TQT4_HUMAN | PMS2 | 267 | ||
A0A8V8TP84 | A0A8V8TP84_HUMAN | PMS2 | 671 | ||
A0A8V8TP89 | A0A8V8TP89_HUMAN | PMS2 | 771 | ||
A0A8V8TPD1 | A0A8V8TPD1_HUMAN | PMS2 | 71 | ||
A0A8V8TPE1 | A0A8V8TPE1_HUMAN | PMS2 | 806 | ||
A0A8V8TPE7 | A0A8V8TPE7_HUMAN | PMS2 | 264 | ||
A0A8V8TPJ6 | A0A8V8TPJ6_HUMAN | PMS2 | 207 | ||
A0A8V8TPK2 | A0A8V8TPK2_HUMAN | PMS2 | 347 | ||
A0A8V8TQ41 | A0A8V8TQ41_HUMAN | PMS2 | 48 | ||
A0A8V8TQ50 | A0A8V8TQ50_HUMAN | PMS2 | 873 | ||
A0A8V8TQ88 | A0A8V8TQ88_HUMAN | PMS2 | 247 | ||
A0A8V8TQ92 | A0A8V8TQ92_HUMAN | PMS2 | 738 | ||
A0A8V8TNV6 | A0A8V8TNV6_HUMAN | PMS2 | 100 | ||
A0A8V8TNW1 | A0A8V8TNW1_HUMAN | PMS2 | 91 | ||
A0A8V8TNX1 | A0A8V8TNX1_HUMAN | PMS2 | 72 | ||
A0A8V8TNX6 | A0A8V8TNX6_HUMAN | PMS2 | 924 | ||
A0A8V8TNY8 | A0A8V8TNY8_HUMAN | PMS2 | 796 | ||
A0A8V8TNZ8 | A0A8V8TNZ8_HUMAN | PMS2 | 161 | ||
A0A8V8TP55 | A0A8V8TP55_HUMAN | PMS2 | 399 | ||
A0A8V8TP66 | A0A8V8TP66_HUMAN | PMS2 | 182 | ||
A0A8V8TP72 | A0A8V8TP72_HUMAN | PMS2 | 861 | ||
A0A8V8TP79 | A0A8V8TP79_HUMAN | PMS2 | 119 | ||
A0A8V8TNQ7 | A0A8V8TNQ7_HUMAN | PMS2 | 47 | ||
A0A8V8TNR3 | A0A8V8TNR3_HUMAN | PMS2 | 151 | ||
A0A8V8TNR7 | A0A8V8TNR7_HUMAN | PMS2 | 530 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 208-253 | Basic and acidic residues | ||||
Sequence: PMVEKQDQSPSLRTGEEKKDVSISRLREAFSLRHTTENKPHSPKTP | ||||||
Compositional bias | 263-277 | Polar residues | ||||
Sequence: KRGMLSSSTSGAISD | ||||||
Compositional bias | 297-311 | Basic and acidic residues | ||||
Sequence: PTDRAEVEKDSGHGS | ||||||
Compositional bias | 312-337 | Polar residues | ||||
Sequence: TSVDSEGFSIPDTGSHCSSEYAASSP | ||||||
Compositional bias | 343-365 | Basic and acidic residues | ||||
Sequence: QEHVDSQEKAPKTDDSFSDVDCH |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AC005995 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. |