A0A8V8TNK7 · A0A8V8TNK7_HUMAN
- ProteinADAM metallopeptidase domain 17
- GeneADAM17
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids577 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score2/5
Function
Cofactor
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 405 | Zn2+ (UniProtKB | ChEBI); catalytic | |||
Active site | 406 | ||||
Binding site | 409 | Zn2+ (UniProtKB | ChEBI); catalytic | |||
Binding site | 415 | Zn2+ (UniProtKB | ChEBI); catalytic | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | membrane | |
Molecular Function | metal ion binding | |
Molecular Function | metalloendopeptidase activity | |
Biological Process | proteolysis | |
Biological Process | regulation of cellular component organization |
Keywords
- Molecular function
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Submitted names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionA0A8V8TNK7
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Membrane ; Single-pass type I membrane protein
Keywords
- Cellular component
Disease & Variants
Variants
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The viewer provides 443 variants from UniProt as well as other sources including ClinVar and dbSNP.
Genetic variation databases
PTM/Processing
Features
Showing features for signal, chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Signal | 1-17 | ||||
Chain | PRO_5036444046 | 18-577 | |||
Proteomic databases
Sequence
- Sequence statusComplete
- Length577
- Mass (Da)65,589
- Last updated2022-12-14 v1
- ChecksumE9ECA55B52BD1004
Computationally mapped potential isoform sequences
There are 11 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
P78536 | ADA17_HUMAN | ADAM17 | 824 | ||
A8K1B4 | A8K1B4_HUMAN | ADAM17 | 212 | ||
A0A8V8TPG8 | A0A8V8TPG8_HUMAN | ADAM17 | 285 | ||
A0A8V8TPV7 | A0A8V8TPV7_HUMAN | ADAM17 | 551 | ||
A0A8V8TNK2 | A0A8V8TNK2_HUMAN | ADAM17 | 53 | ||
A0A8V8TN27 | A0A8V8TN27_HUMAN | ADAM17 | 794 | ||
A0A3B3ISQ1 | A0A3B3ISQ1_HUMAN | ADAM17 | 181 | ||
A0A3B3ITB5 | A0A3B3ITB5_HUMAN | ADAM17 | 59 | ||
A0A3B3IST4 | A0A3B3IST4_HUMAN | ADAM17 | 56 | ||
A0A3B3ITW9 | A0A3B3ITW9_HUMAN | ADAM17 | 38 | ||
A6H8L4 | A6H8L4_HUMAN | ADAM17 | 258 |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AC073195 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AC080162 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AC092206 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. |