A0A8V8TNK7 · A0A8V8TNK7_HUMAN

  • Protein
    ADAM metallopeptidase domain 17
  • Gene
    ADAM17
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    2/5

Function

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Features

Showing features for binding site, active site.

157750100150200250300350400450500550
Type
IDPosition(s)Description
Binding site405Zn2+ (UniProtKB | ChEBI); catalytic
Active site406
Binding site409Zn2+ (UniProtKB | ChEBI); catalytic
Binding site415Zn2+ (UniProtKB | ChEBI); catalytic

GO annotations

AspectTerm
Cellular Componentmembrane
Molecular Functionmetal ion binding
Molecular Functionmetalloendopeptidase activity
Biological Processproteolysis
Biological Processregulation of cellular component organization

Keywords

Names & Taxonomy

Protein names

  • Submitted names
    • ADAM metallopeptidase domain 17

Gene names

    • Name
      ADAM17

Organism names

  • Taxonomic identifier
  • Organism
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    A0A8V8TNK7

Proteomes

Organism-specific databases

Subcellular Location

Membrane
; Single-pass type I membrane protein

Keywords

  • Cellular component

Disease & Variants

Variants

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The viewer provides 443 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Genetic variation databases

PTM/Processing

Features

Showing features for signal, chain.

Type
IDPosition(s)Description
Signal1-17
ChainPRO_503644404618-577

Proteomic databases

Structure

3D structure databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain223-474Peptidase M12B
Domain475-555Disintegrin

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    577
  • Mass (Da)
    65,589
  • Last updated
    2022-12-14 v1
  • Checksum
    E9ECA55B52BD1004
MRQSLLFLTSVVPFVLAPRPPDDPGFGPHQRLEKLDSLLSDYDILSLSNIQQHSVRKRDLQTSTHVETLLTFSALKRHFKLYLTSSTERFSQNFKVVVVDGKNESEYTVKWQDFFTGHVVGEPDSRVLAHIRDDDVIIRINTDGAEYNIEPLWRFVNDTKDKRMLVYKSEDIKNVSRLQSPKVCGYLKVDNEELLPKGLVDREPPEELVHRVKRRADPDPMKNTCKLLVVADHRFYRYMGRGEESTTTNYLIELIDRVDDIYRNTSWDNAGFKGYGIQIEQIRILKSPQEVKPGEKHYNMAKSYPNEEKDAWDVKMLLEQFSFDIAEEASKVCLAHLFTYQDFDMGTLGLAYVGSPRANSHGGVCPKAYYSPVGKKNIYLNSGLTSTKNYGKTILTKEADLVTTHELGHNFGAEHDPDGLAECAPNEDQGGKYVMYPIAVSGDHENNKMFSNCSKQSIYKTIESKAQECFQERSNKVCGNSRVDEGEECDPGIMYLNNDTCCNSDCTLKEGVQCSDRNSPCCKNCQFETAQKKCQEAINATCKGVSYCTGSCSCCFLGMLWVKCVCVFEKQDYVLFR

Computationally mapped potential isoform sequences

There are 11 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
P78536ADA17_HUMANADAM17824
A8K1B4A8K1B4_HUMANADAM17212
A0A8V8TPG8A0A8V8TPG8_HUMANADAM17285
A0A8V8TPV7A0A8V8TPV7_HUMANADAM17551
A0A8V8TNK2A0A8V8TNK2_HUMANADAM1753
A0A8V8TN27A0A8V8TN27_HUMANADAM17794
A0A3B3ISQ1A0A3B3ISQ1_HUMANADAM17181
A0A3B3ITB5A0A3B3ITB5_HUMANADAM1759
A0A3B3IST4A0A3B3IST4_HUMANADAM1756
A0A3B3ITW9A0A3B3ITW9_HUMANADAM1738
A6H8L4A6H8L4_HUMANADAM17258

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AC073195
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AC080162
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AC092206
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.

Genome annotation databases

Similar Proteins

Disclaimer

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