A0A8V8TNG7 · A0A8V8TNG7_HUMAN

  • Protein
    CF transmembrane conductance regulator
  • Gene
    CFTR
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    1/5

Function

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentmembrane
Molecular FunctionABC-type transporter activity
Molecular FunctionATP binding
Molecular Functionchloride channel activity

Keywords

Names & Taxonomy

Protein names

  • Submitted names
    • CF transmembrane conductance regulator

Gene names

    • Name
      CFTR

Organism names

  • Taxonomic identifier
  • Organism
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    A0A8V8TNG7

Proteomes

Organism-specific databases

Subcellular Location

Membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane119-143Helical
Transmembrane195-215Helical
Transmembrane221-241Helical
Transmembrane304-326Helical

Keywords

  • Cellular component

Disease & Variants

Variants

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The viewer provides 842 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Genetic variation databases

PTM/Processing

Proteomic databases

Structure

3D structure databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain86-323ABC transmembrane type-1

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    478
  • Mass (Da)
    54,822
  • Last updated
    2022-12-14 v1
  • Checksum
    E67C78BCC2FB6C33
MQRSPLEKASVVSKLFFSWTRPILRKGYRQRLELSDIYQIPSVDSADNLSEKLEREWDRELASKKNPKLINALRRCFFWRFMFYGIFLYLGEVTKAVQPLLLGRIIASYDPDNKEERSIAIYLGIGLCLLFIVRTLLLHPAIFGLHHIGMQMRIAMFSLIYKKTLKLSSRVLDKISIGQLVSLLSNNLNKFDEGLALAHFVWIAPLQVALLMGLIWELLQASAFCGLGFLIVLALFQAGLGRMMMKYRDQRAGKISERLVITSEMIENIQSVKAYCWEEAMEKMIENLRQTELKLTRKAAYVRYFNSSAFFFSGFFVVFLSVLPYALIKGIILRKIFTTISFCIVLRMAVTRQFPWAVQTWYDSLGAINKIQDFLQKQEYKTLEYNLTTTEVVMENVTAFWEEGFGELFEKAKQNNNNRKTSNGDDSLFFSNFSLLGTPVLKDINFKIERGQLLAVAGSTGADFTSNGDYGRTGAFRG

Computationally mapped potential isoform sequences

There are 19 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
P13569CFTR_HUMANCFTR1480
C9J6L5C9J6L5_HUMANCFTR36
E7EPB6E7EPB6_HUMANCFTR1438
H0Y8A9H0Y8A9_HUMANCFTR190
M0QYZ3M0QYZ3_HUMANCFTR156
A0A8V8TPV6A0A8V8TPV6_HUMANCFTR1338
A0A8V8TQ89A0A8V8TQ89_HUMANCFTR536
A0A8V8TQ94A0A8V8TQ94_HUMANCFTR564
A0A8V8TNH2A0A8V8TNH2_HUMANCFTR1478
A0A8V8TNN0A0A8V8TNN0_HUMANCFTR1428
A0A8V8TNN7A0A8V8TNN7_HUMANCFTR57
A0A3B3IT97A0A3B3IT97_HUMANCFTR58
A0A3B3ITE0A0A3B3ITE0_HUMANCFTR1196
A0A3B3ITW0A0A3B3ITW0_HUMANCFTR842
A0A3B3ITW5A0A3B3ITW5_HUMANCFTR1187
A0A8I5KVV2A0A8I5KVV2_HUMANCFTR1300
A0A8I5KVL1A0A8I5KVL1_HUMANCFTR1180
A0A8I5KXQ9A0A8I5KXQ9_HUMANCFTR280
A0A669KBE8A0A669KBE8_HUMANCFTR333

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AC000061
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AC000111
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AC002465
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AC003045
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
KF458571
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
KF458574
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
KF458577
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.

Genome annotation databases

Similar Proteins

Disclaimer

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