A0A8V8TNB8 · A0A8V8TNB8_HUMAN
- ProteinLow affinity immunoglobulin gamma Fc region receptor III-A
- GeneFCGR3A
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids262 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score1/5
Function
Names & Taxonomy
Protein names
- Recommended nameLow affinity immunoglobulin gamma Fc region receptor III-A
Gene names
Organism names
- Organism
- Taxonomic lineagecellular organisms > Eukaryota (eucaryotes) > Opisthokonta > Metazoa (metazoans) > Eumetazoa > Bilateria > Deuterostomia > Chordata (chordates) > Craniata > Vertebrata (vertebrates) > Gnathostomata (jawed vertebrates) > Teleostomi > Euteleostomi (bony vertebrates) > Sarcopterygii > Dipnotetrapodomorpha > Tetrapoda (tetrapods) > Amniota (amniotes) > Mammalia (mammals) > Theria > Eutheria (placentals) > Boreoeutheria > Euarchontoglires > Primates > Haplorrhini > Simiiformes > Catarrhini > Hominoidea (apes) > Hominidae (great apes) > Homininae > Homo
Accessions
- Primary accessionA0A8V8TNB8
Proteomes
Organism-specific databases
Disease & Variants
Variants
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The viewer provides 407 variants from UniProt as well as other sources including ClinVar and dbSNP.
Genetic variation databases
PTM/Processing
Features
Showing features for signal, chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-20 | |||||
Sequence: MWQLLLPTALLLLVSAGMRT | ||||||
Chain | PRO_5036494508 | 21-262 | Low affinity immunoglobulin gamma Fc region receptor III-A | |||
Sequence: EDLPKAVVFLEPQWYRVLEKDSVTLKCQGAYSPEDNSTQWFHNESLISSQASSYFIDAATVDDSGEYRCQTNLSTLSDPVQLEVHIGWLLLQAPRWVFKEEDPIHLRCHSWKNTALHKVTYLQNGKGRKYFHHNSDFYIPKATLKDSGSYFCRGLFGSKNVSSETVNITITQGETCATLECPGTPVCGTCNHTGKLSWEEIPDSYTHFFICGSLLVITRRSPKVPDCRVGLQLCFSPFFWGS |
Proteomic databases
Interaction
Subunit
Forms a heterooligomeric complex with ITAM-containing signaling subunits FCER1G. Interacts (via transmembrane domain) with signaling subunits; this interaction is a prerequisite for receptor complex expression on the cell surface and intracellular signal transduction. Binds the Fc region of antigen-complexed IgG.
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 24-105 | Ig-like | ||||
Sequence: PKAVVFLEPQWYRVLEKDSVTLKCQGAYSPEDNSTQWFHNESLISSQASSYFIDAATVDDSGEYRCQTNLSTLSDPVQLEVH | ||||||
Domain | 120-189 | Ig-like | ||||
Sequence: EEDPIHLRCHSWKNTALHKVTYLQNGKGRKYFHHNSDFYIPKATLKDSGSYFCRGLFGSKNVSSETVNIT |
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length262
- Mass (Da)29,627
- Last updated2022-12-14 v1
- Checksum9574E812A900A33F
Computationally mapped potential isoform sequences
There are 6 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
P08637 | FCG3A_HUMAN | FCGR3A | 254 | ||
H0Y755 | H0Y755_HUMAN | FCGR3A | 253 | ||
C9JC71 | C9JC71_HUMAN | FCGR3A | 135 | ||
A0A8V8TPL1 | A0A8V8TPL1_HUMAN | FCGR3A | 237 | ||
A0A8V8TQ03 | A0A8V8TQ03_HUMAN | FCGR3A | 269 | ||
A0A8V8TNB3 | A0A8V8TNB3_HUMAN | FCGR3A | 110 |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AL590385 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. |