A0A8V8TN27 · A0A8V8TN27_HUMAN

  • Protein
    ADAM metallopeptidase domain 17
  • Gene
    ADAM17
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    2/5

Function

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Features

Showing features for binding site, active site.

1794100200300400500600700
Type
IDPosition(s)Description
Binding site375Zn2+ (UniProtKB | ChEBI); catalytic
Active site376
Binding site379Zn2+ (UniProtKB | ChEBI); catalytic
Binding site385Zn2+ (UniProtKB | ChEBI); catalytic

GO annotations

AspectTerm
Cellular Componentmembrane
Molecular Functionmetal ion binding
Molecular Functionmetalloendopeptidase activity
Biological Processproteolysis
Biological Processregulation of cellular component organization

Keywords

Names & Taxonomy

Protein names

  • Submitted names
    • ADAM metallopeptidase domain 17

Gene names

    • Name
      ADAM17

Organism names

  • Taxonomic identifier
  • Organism
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    A0A8V8TN27

Proteomes

Organism-specific databases

Subcellular Location

Membrane
; Single-pass type I membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane642-664Helical

Keywords

  • Cellular component

Disease & Variants

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 645 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Genetic variation databases

PTM/Processing

Features

Showing features for signal, chain, modified residue (large scale data).

Type
IDPosition(s)Source
Description
Signal1-17UniProt
ChainPRO_503645606018-794UniProt
Modified residue (large scale data)672PRIDEPhosphotyrosine
Modified residue (large scale data)705PRIDEPhosphothreonine
Modified residue (large scale data)755PRIDEPhosphoserine
Modified residue (large scale data)761PRIDEPhosphoserine
Modified residue (large scale data)778PRIDEPhosphoserine
Modified residue (large scale data)789PRIDEPhosphoserine

Proteomic databases

Structure

3D structure databases

Family & Domains

Features

Showing features for domain, region, compositional bias.

Type
IDPosition(s)Description
Domain282-444Peptidase M12B
Domain445-533Disintegrin
Region705-794Disordered
Compositional bias727-750Basic and acidic residues
Compositional bias765-794Basic and acidic residues

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    794
  • Mass (Da)
    89,509
  • Last updated
    2022-12-14 v1
  • Checksum
    9B77E456036A7F36
MRQSLLFLTSVVPFVLAPRPPDDPGFGPHQRLEKLDSLLSDYDILSLSNIQQHSVRKRDLQTSTHVETLLTFSALKRHFKLYLTSSTERFSQNFKVVVVDGKNESEYTVKWQDFFTGHVVGEPDSRVLAHIRDDDVIIRINTDGAEYNIEPLWRFVNDTKDKRMLVYKSEDIKNVSRLQSPKVCGYLKVDNEELLPKGLVDREPPEELVHRVKRRADPDPMKNTCKLLVVADHRFYRYMGRGEESTTTNYLIRILKSPQEVKPGEKHYNMAKSYPNEEKDAWDVKMLLEQFSFDIAEEASKVCLAHLFTYQDFDMGTLGLAYVGSPRANSHGGVCPKAYYSPVGKKNIYLNSGLTSTKNYGKTILTKEADLVTTHELGHNFGAEHDPDGLAECAPNEDQGGKYVMYPIAVSGDHENNKMFSNCSKQSIYKTIESKAQECFQERSNKVCGNSRVDEGEECDPGIMYLNNDTCCNSDCTLKEGVQCSDRNSPCCKNCQFETAQKKCQEAINATCKGVSYCTGNSSECPPPGNAEDDTVCLDLGKCKDGKCIPFCEREQQLESCACNETDNSCKVCCRDLSGRCVPYVDAEQKNLFLRKGKPCTVGFCDMNGKCEKRVQDVIERFWDFIDQLSINTFGKFLADNIVGSVLVFSLIFWIPFSILVHCVDKKLDKQYESLSLFHPSNVEMLSSMDSASVRIIKPFPAPQTPGRLQPAPVIPSAPAAPKLDHQRMDTIQEDPSTDSHMDEDGFEKDPFPNSSTAAKSFEDLTDHPVTRSEKAASFKLQRQNRVDSKETEC

Computationally mapped potential isoform sequences

There are 11 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
P78536ADA17_HUMANADAM17824
A8K1B4A8K1B4_HUMANADAM17212
A0A8V8TPG8A0A8V8TPG8_HUMANADAM17285
A0A8V8TPV7A0A8V8TPV7_HUMANADAM17551
A0A8V8TNK2A0A8V8TNK2_HUMANADAM1753
A0A8V8TNK7A0A8V8TNK7_HUMANADAM17577
A0A3B3ISQ1A0A3B3ISQ1_HUMANADAM17181
A0A3B3ITB5A0A3B3ITB5_HUMANADAM1759
A0A3B3IST4A0A3B3IST4_HUMANADAM1756
A0A3B3ITW9A0A3B3ITW9_HUMANADAM1738
A6H8L4A6H8L4_HUMANADAM17258

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias727-750Basic and acidic residues
Compositional bias765-794Basic and acidic residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AC073195
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AC080162
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AC092206
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.

Genome annotation databases

Similar Proteins

Disclaimer

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