A0A8V8TMZ9 · A0A8V8TMZ9_HUMAN

  • Protein
    Transporter
  • Gene
    SLC6A1
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    2/5

Function

Features

Showing features for binding site.

162350100150200250300350400450500550600
TypeIDPosition(s)Description
Binding site83Na+ 1 (UniProtKB | ChEBI)
Binding site85Na+ 1 (UniProtKB | ChEBI)
Binding site90Na+ 1 (UniProtKB | ChEBI)
Binding site319Na+ 1 (UniProtKB | ChEBI)
Binding site351Na+ 1 (UniProtKB | ChEBI)
Binding site416Na+ 1 (UniProtKB | ChEBI)
Binding site419Na+ 1 (UniProtKB | ChEBI)
Binding site420Na+ 1 (UniProtKB | ChEBI)

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentplasma membrane
Molecular Functiongamma-aminobutyric acid:sodium:chloride symporter activity
Biological Processneurotransmitter transport

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Transporter

Gene names

    • Name
      SLC6A1

Organism names

  • Taxonomic identifier
  • Organism
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    A0A8V8TMZ9

Proteomes

Organism-specific databases

Subcellular Location

Membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane77-95Helical
Transmembrane107-128Helical
Transmembrane149-176Helical
Transmembrane234-253Helical
Transmembrane265-288Helical
Transmembrane308-333Helical
Transmembrane345-370Helical
Transmembrane404-425Helical
Transmembrane446-471Helical
Transmembrane477-501Helical
Transmembrane522-541Helical
Transmembrane561-581Helical

Keywords

  • Cellular component

Disease & Variants

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 545 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Genetic variation databases

PTM/Processing

Features

Showing features for disulfide bond.

TypeIDPosition(s)Description
Disulfide bond188↔197

Keywords

Structure

3D structure databases

Family & Domains

Features

Showing features for region, compositional bias.

TypeIDPosition(s)Description
Region602-623Disordered
Compositional bias609-623Polar residues

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    623
  • Mass (Da)
    69,678
  • Last updated
    2022-12-14 v1
  • Checksum
    0DEF4192C6F49F91
MLSTWTGGDIARPSARTPASKFRDMATNGSKVADGQISTEVSEAPVANDKPKTLVVKVQKKAADLPDRDTWKGRFDFLMSCVGYAIGLGNVWRFPYLCGKNGGGAFLIPYFLTLIFAGVPLFLLECSLGQYTSIGGLGVWKLAPMFKGVGLAAAVLSFWLNIYYIVIISWAIYYLYNSFTTTLPWKQCDNPWNTDRCFSNYSMVNTTNMTSAVVEFWERNMHQMTDGLDKPGQIRWPLAITLAIAWILVYFCIWKGVGWTGKVVYFSATYPYIMLIILFFRGVTLPGAKEGILFYITPNFRKLSDSEVWLDAATQIFFSYGLGLGSLIALGSYNSFHNNVYRDSIIVCCINSCTSMFAGFVIFSIVGFMAHVTKRSIADVAASGPGLAFLAYPEAVTQLPISPLWAILFFSMLLMLGIDSQFCTVEGFITALVDEYPRLLRNRRELFIAAVCIISYLIGLSNITQGGIYVFKLFDYYSASGMSLLFLVFFECVSISWFYGVNRFYDNIQEMVGSRPCIWWKLCWSFFTPIIVAGVFIFSAVQMTPLTMGNYVFPKWGQGVGWLMALSSMVLIPGYMAYMFLTLKGSLKQRIQVMVQPSEDIVRPENGPEQPQAGSSTSKEAYI

Computationally mapped potential isoform sequences

There are 12 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
P30531SC6A1_HUMANSLC6A1599
C9J5P8C9J5P8_HUMANSLC6A1125
A0A2R8Y867A0A2R8Y867_HUMANSLC6A1458
A0A2R8Y3X2A0A2R8Y3X2_HUMANSLC6A1171
A0A2R8Y495A0A2R8Y495_HUMANSLC6A1184
A0A2R8Y4I3A0A2R8Y4I3_HUMANSLC6A1479
A0A2R8YDD5A0A2R8YDD5_HUMANSLC6A1608
A0A2R8YCM3A0A2R8YCM3_HUMANSLC6A1380
A0A2R8YFI0A0A2R8YFI0_HUMANSLC6A1112
A0A2R8YF74A0A2R8YF74_HUMANSLC6A1515
A0A2R8YEF0A0A2R8YEF0_HUMANSLC6A1162
B7Z3C5B7Z3C5_HUMANSLC6A1421

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias609-623Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AC024910
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
KF457578
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
KF457580
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.

Genome annotation databases

Similar Proteins

Disclaimer

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