A0A8V8TMZ9 · A0A8V8TMZ9_HUMAN
- ProteinTransporter
- GeneSLC6A1
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids623 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score2/5
Function
Features
Showing features for binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 83 | Na+ 1 (UniProtKB | ChEBI) | ||||
Sequence: G | ||||||
Binding site | 85 | Na+ 1 (UniProtKB | ChEBI) | ||||
Sequence: A | ||||||
Binding site | 90 | Na+ 1 (UniProtKB | ChEBI) | ||||
Sequence: N | ||||||
Binding site | 319 | Na+ 1 (UniProtKB | ChEBI) | ||||
Sequence: S | ||||||
Binding site | 351 | Na+ 1 (UniProtKB | ChEBI) | ||||
Sequence: N | ||||||
Binding site | 416 | Na+ 1 (UniProtKB | ChEBI) | ||||
Sequence: L | ||||||
Binding site | 419 | Na+ 1 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 420 | Na+ 1 (UniProtKB | ChEBI) | ||||
Sequence: S |
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Aspect | Term | |
---|---|---|
Cellular Component | plasma membrane | |
Molecular Function | gamma-aminobutyric acid:sodium:chloride symporter activity | |
Biological Process | neurotransmitter transport |
Keywords
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended nameTransporter
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionA0A8V8TMZ9
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 77-95 | Helical | ||||
Sequence: FLMSCVGYAIGLGNVWRFP | ||||||
Transmembrane | 107-128 | Helical | ||||
Sequence: LIPYFLTLIFAGVPLFLLECSL | ||||||
Transmembrane | 149-176 | Helical | ||||
Sequence: VGLAAAVLSFWLNIYYIVIISWAIYYLY | ||||||
Transmembrane | 234-253 | Helical | ||||
Sequence: IRWPLAITLAIAWILVYFCI | ||||||
Transmembrane | 265-288 | Helical | ||||
Sequence: YFSATYPYIMLIILFFRGVTLPGA | ||||||
Transmembrane | 308-333 | Helical | ||||
Sequence: VWLDAATQIFFSYGLGLGSLIALGSY | ||||||
Transmembrane | 345-370 | Helical | ||||
Sequence: IIVCCINSCTSMFAGFVIFSIVGFMA | ||||||
Transmembrane | 404-425 | Helical | ||||
Sequence: LWAILFFSMLLMLGIDSQFCTV | ||||||
Transmembrane | 446-471 | Helical | ||||
Sequence: LFIAAVCIISYLIGLSNITQGGIYVF | ||||||
Transmembrane | 477-501 | Helical | ||||
Sequence: YSASGMSLLFLVFFECVSISWFYGV | ||||||
Transmembrane | 522-541 | Helical | ||||
Sequence: LCWSFFTPIIVAGVFIFSAV | ||||||
Transmembrane | 561-581 | Helical | ||||
Sequence: GWLMALSSMVLIPGYMAYMFL |
Keywords
- Cellular component
Disease & Variants
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 545 variants from UniProt as well as other sources including ClinVar and dbSNP.
Genetic variation databases
PTM/Processing
Features
Showing features for disulfide bond.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Disulfide bond | 188↔197 | |||||
Sequence: CDNPWNTDRC |
Keywords
- PTM
Family & Domains
Features
Showing features for region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 602-623 | Disordered | ||||
Sequence: VRPENGPEQPQAGSSTSKEAYI | ||||||
Compositional bias | 609-623 | Polar residues | ||||
Sequence: EQPQAGSSTSKEAYI |
Sequence similarities
Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length623
- Mass (Da)69,678
- Last updated2022-12-14 v1
- Checksum0DEF4192C6F49F91
Computationally mapped potential isoform sequences
There are 12 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
P30531 | SC6A1_HUMAN | SLC6A1 | 599 | ||
C9J5P8 | C9J5P8_HUMAN | SLC6A1 | 125 | ||
A0A2R8Y867 | A0A2R8Y867_HUMAN | SLC6A1 | 458 | ||
A0A2R8Y3X2 | A0A2R8Y3X2_HUMAN | SLC6A1 | 171 | ||
A0A2R8Y495 | A0A2R8Y495_HUMAN | SLC6A1 | 184 | ||
A0A2R8Y4I3 | A0A2R8Y4I3_HUMAN | SLC6A1 | 479 | ||
A0A2R8YDD5 | A0A2R8YDD5_HUMAN | SLC6A1 | 608 | ||
A0A2R8YCM3 | A0A2R8YCM3_HUMAN | SLC6A1 | 380 | ||
A0A2R8YFI0 | A0A2R8YFI0_HUMAN | SLC6A1 | 112 | ||
A0A2R8YF74 | A0A2R8YF74_HUMAN | SLC6A1 | 515 | ||
A0A2R8YEF0 | A0A2R8YEF0_HUMAN | SLC6A1 | 162 | ||
B7Z3C5 | B7Z3C5_HUMAN | SLC6A1 | 421 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 609-623 | Polar residues | ||||
Sequence: EQPQAGSSTSKEAYI |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AC024910 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
KF457578 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
KF457580 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. |