A0A8V8TMM0 · A0A8V8TMM0_HUMAN
- Proteinphosphatidylinositol-4,5-bisphosphate 3-kinase
- GenePIK3CD
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids1040 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score2/5
Function
Catalytic activity
- a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + ADP + H+This reaction proceeds in the forward direction.
Pathway
Phospholipid metabolism; phosphatidylinositol phosphate biosynthesis.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Molecular Function | 1-phosphatidylinositol-3-kinase activity | |
Biological Process | phosphatidylinositol 3-kinase/protein kinase B signal transduction | |
Biological Process | phosphatidylinositol-mediated signaling |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namephosphatidylinositol-4,5-bisphosphate 3-kinase
- EC number
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionA0A8V8TMM0
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Disease & Variants
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 683 variants from UniProt as well as other sources including ClinVar and dbSNP.
Genetic variation databases
PTM/Processing
Features
Showing features for modified residue (large scale data).
Type | ID | Position(s) | Source | Description | |||
---|---|---|---|---|---|---|---|
Modified residue (large scale data) | 516 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 1035 | PRIDE | Phosphoserine | ||||
Sequence: S |
Proteomic databases
Family & Domains
Features
Showing features for domain, region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 16-105 | PI3K-ABD | ||||
Sequence: ENQSVVVDFLLPTGVYLNFPVSRNANLSTIKQLLWHRAQYEPLFHMLSGPEAYVFTCINQTAEQQELEDEQRRLCDVQPFLPVLRLVARE | ||||||
Domain | 187-278 | PI3K-RBD | ||||
Sequence: NRALLVNVKFEGSEESFTFQVSTKDVPLALMACALRKKATVFRQPLVEQPEDYTLQVNGRHEYLYGSYPLCQFQYICSCLHSGLTPHLTMVH | ||||||
Region | 287-307 | Disordered | ||||
Sequence: DEQSNPAPQVQKPRAKPPPIP | ||||||
Domain | 319-472 | C2 PI3K-type | ||||
Sequence: LEQPFRIELIQGSKVNADERMKAGLFHGNEMLCKTVSSSEVSVCSEPVWKQRLEFDINICDLPRMARLCFALYAVIEKAKKARSTKKKSKKADCPIAWANLMLFDYKDQLKTGERCLYMWPSVPDEKGELLNPTGTVRSNPNTDSAAALLICLP | ||||||
Domain | 493-670 | PIK helical | ||||
Sequence: HSECVHVTEEEQLQLREILERRGSGELYEHEKDLVWKLRHEVQEHFPEALARLLLVTKWNKHEDVAQMLYLLCSWPELPVLSALELLDFSFPDCHVGSFAIKSLRKLTDDELFQYLLQLVQVLKYESYLDCELTKFLLDRALANRKIGHFLFWHLRSEMHVPSVALRFGLILEAYCRG | ||||||
Domain | 741-1023 | PI3K/PI4K catalytic | ||||
Sequence: CVEQCTFMDSKMKPLWIMYSNEEAGSGGSVGIIFKNGDDLRQDMLTLQMIQLMDVLWKQEGLDLRMTPYGCLPTGDRTGLIEVVLRSDTIANIQLNKSNMAATAAFNKDALLNWLKSKNPGEALDRAIEEFTLSCAGYCVATYVLGIGDRHSDNIMIRESGQLFHIDFGHFLGNFKTKFGINRERVPFILTYDFVHVIQQGKTNNSEKFERFRGYCERAYTILRRHGLLFLHLFALMRAAGLPELSCSKDIQYLKDSLALGKTEEEALKHFRVKFNEALRESW |
Sequence similarities
Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,040
- Mass (Da)119,040
- Last updated2022-12-14 v1
- Checksum86FFC98B208BFB8C
Computationally mapped potential isoform sequences
There are 7 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
O00329 | PK3CD_HUMAN | PIK3CD | 1044 | ||
B7ZM44 | B7ZM44_HUMAN | PIK3CD | 1043 | ||
F8W9P4 | F8W9P4_HUMAN | PIK3CD | 1068 | ||
A0A8V8TNW9 | A0A8V8TNW9_HUMAN | PIK3CD | 1012 | ||
A0A8V8TNP1 | A0A8V8TNP1_HUMAN | PIK3CD | 197 | ||
A0A8V8TM62 | A0A8V8TM62_HUMAN | PIK3CD | 996 | ||
A0A8V8TML5 | A0A8V8TML5_HUMAN | PIK3CD | 51 |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AL691449 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AL954705 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. |