A0A8V8TM63 · A0A8V8TM63_HUMAN
- ProteinHistone deacetylase 6
- GeneHDAC6
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids921 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score1/5
Function
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Aspect | Term | |
---|---|---|
Cellular Component | nucleus | |
Molecular Function | protein lysine deacetylase activity |
Keywords
- Molecular function
Names & Taxonomy
Protein names
- Submitted names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionA0A8V8TM63
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Disease & Variants
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 469 variants from UniProt as well as other sources including ClinVar and dbSNP.
Genetic variation databases
PTM/Processing
Features
Showing features for modified residue (large scale data).
Type | ID | Position(s) | Source | Description | |||
---|---|---|---|---|---|---|---|
Modified residue (large scale data) | 16 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 22 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 43 | PRIDE | Phosphoserine | ||||
Sequence: S |
Proteomic databases
Family & Domains
Features
Showing features for compositional bias, region, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 1-34 | Polar residues | ||||
Sequence: MTSTGQDSTTTRQRRSRQNPQSPPQDSSVTSKRN | ||||||
Region | 1-44 | Disordered | ||||
Sequence: MTSTGQDSTTTRQRRSRQNPQSPPQDSSVTSKRNIKKGAVPRSI | ||||||
Domain | 106-401 | Histone deacetylase | ||||
Sequence: PEGPERLHAIKEQLIQEGLLDRCVSFQARFAEKEELMLVHSLEYIDLMETTQYMNEGELRVLADTYDSVYLHPNSYSCACLASGSVLRLVDAVLGAEIRNGMAIIRPPGHHAQHSLMDGYCMFNHVAVAARYAQQKHRIRRVLIVDWDVHHGQGTQFTFDQDPSVLYFSIHRYEQGRFWPHLKASNWSTTGFGQGQGYTINVPWNQVGMRDADYIAAFLHVLLPVALEFQPQLVLVAAGFDALQGDPKGEMAATPAGFAQLTHLLMGLAGGKLILSLEGGYNLRALAEGVSASLHT | ||||||
Domain | 500-797 | Histone deacetylase | ||||
Sequence: HPEVPQRILRIMCRLEELGLAGRCLTLTPRPATEAELLTCHSAEYVGHLRATEKMKTRELHRESSNFDSIYICPSTFACAQLATGAACRLVEAVLSGEVLNGAAVVRPPGHHAEQDAACGFCFFNSVAVAARHAQTISGHALRILIVDWDVHHGNGTQHMFEDDPSVLYVSLHRYDHGTFFPMGDEGASSQIGRAAGTGFTVNVAWNGPRMGDADYLAAWHRLVLPIAYEFNPELVLVSAGFDAARGDPLGGCQVSPEGYAHLTHLLMGLASGRIILILEGGYNLTSISESMAACTRS | ||||||
Region | 842-863 | Disordered | ||||
Sequence: REGPSSSKLVTKKAPQPAKPRL | ||||||
Region | 887-921 | Disordered | ||||
Sequence: SQDLGARQRISGGLRISGPRRGEPTRRGSWRSGHG | ||||||
Compositional bias | 906-921 | Basic and acidic residues | ||||
Sequence: RRGEPTRRGSWRSGHG |
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length921
- Mass (Da)101,551
- Last updated2022-12-14 v1
- Checksum7C11E77D3DC1EF8E
Computationally mapped potential isoform sequences
There are 16 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
Q9UBN7 | HDAC6_HUMAN | HDAC6 | 1215 | ||
A6NDI8 | A6NDI8_HUMAN | HDAC6 | 210 | ||
C9J172 | C9J172_HUMAN | HDAC6 | 142 | ||
A0A2R8Y6Z9 | A0A2R8Y6Z9_HUMAN | HDAC6 | 669 | ||
A0A2R8Y758 | A0A2R8Y758_HUMAN | HDAC6 | 211 | ||
A0A2R8Y5Z4 | A0A2R8Y5Z4_HUMAN | HDAC6 | 91 | ||
A0A2R8Y559 | A0A2R8Y559_HUMAN | HDAC6 | 1192 | ||
E7EP63 | E7EP63_HUMAN | HDAC6 | 167 | ||
E7ER52 | E7ER52_HUMAN | HDAC6 | 171 | ||
A0A2R8YDE6 | A0A2R8YDE6_HUMAN | HDAC6 | 1160 | ||
A0A2R8YCS4 | A0A2R8YCS4_HUMAN | HDAC6 | 893 | ||
A0A8V8TMA5 | A0A8V8TMA5_HUMAN | HDAC6 | 1108 | ||
A0A8V8TL08 | A0A8V8TL08_HUMAN | HDAC6 | 1166 | ||
A0A8V8TKY7 | A0A8V8TKY7_HUMAN | HDAC6 | 1211 | ||
A0A8V8TLA9 | A0A8V8TLA9_HUMAN | HDAC6 | 701 | ||
Q9BRX7 | Q9BRX7_HUMAN | HDAC6 | 146 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 1-34 | Polar residues | ||||
Sequence: MTSTGQDSTTTRQRRSRQNPQSPPQDSSVTSKRN | ||||||
Compositional bias | 906-921 | Basic and acidic residues | ||||
Sequence: RRGEPTRRGSWRSGHG |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AC231533 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. |