A0A8V8TLA9 · A0A8V8TLA9_HUMAN

  • Protein
    Histone deacetylase 6
  • Gene
    HDAC6
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    1/5

Function

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentnucleus
Molecular Functionprotein lysine deacetylase activity

Keywords

Names & Taxonomy

Protein names

  • Submitted names
    • Histone deacetylase 6

Gene names

    • Name
      HDAC6

Organism names

  • Taxonomic identifier
  • Organism
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    A0A8V8TLA9

Proteomes

Organism-specific databases

Subcellular Location

Disease & Variants

Variants

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The viewer provides 349 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Genetic variation databases

PTM/Processing

Features

Showing features for modified residue (large scale data).

TypeIDPosition(s)SourceDescription
Modified residue (large scale data)16PRIDEPhosphoserine
Modified residue (large scale data)22PRIDEPhosphoserine
Modified residue (large scale data)43PRIDEPhosphoserine

Proteomic databases

Structure

3D structure databases

Family & Domains

Features

Showing features for compositional bias, region, domain.

TypeIDPosition(s)Description
Compositional bias1-34Polar residues
Region1-44Disordered
Domain106-401Histone deacetylase
Domain500-666Histone deacetylase

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    701
  • Mass (Da)
    77,688
  • Last updated
    2022-12-14 v1
  • Checksum
    9733D239F94759A1
MTSTGQDSTTTRQRRSRQNPQSPPQDSSVTSKRNIKKGAVPRSIPNLAEVKKKGKMKKLGQAMEEDLIVGLQGMDLNLEAEALAGTGLVLDEQLNEFHCLWDDSFPEGPERLHAIKEQLIQEGLLDRCVSFQARFAEKEELMLVHSLEYIDLMETTQYMNEGELRVLADTYDSVYLHPNSYSCACLASGSVLRLVDAVLGAEIRNGMAIIRPPGHHAQHSLMDGYCMFNHVAVAARYAQQKHRIRRVLIVDWDVHHGQGTQFTFDQDPSVLYFSIHRYEQGRFWPHLKASNWSTTGFGQGQGYTINVPWNQVGMRDADYIAAFLHVLLPVALEFQPQLVLVAAGFDALQGDPKGEMAATPAGFAQLTHLLMGLAGGKLILSLEGGYNLRALAEGVSASLHTLLGDPCPMLESPGAPCRSAQASVSCALEALEPFWEVLVRSTETVERDNMEEDNVEESEEEGPWEPPVLPILTWPVLQSRTGLVYDQNMMNHCNLWDSHHPEVPQRILRIMCRLEELGLAGRCLTLTPRPATEAELLTCHSAEYVGHLRATEKMKTRELHRESSNFDSIYICPSTFACAQLATGAACRLVEAVLSGEVLNGAAVVRPPGHHAEQDAACGFCFFNSVAVAARHAQTISGHALRILIVDWDVHHGNGTQHMFEDDPSLTQNWCWSQLALMLHGGIRWGAARCHLRVMPTSPTC

Computationally mapped potential isoform sequences

There are 16 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
Q9UBN7HDAC6_HUMANHDAC61215
A6NDI8A6NDI8_HUMANHDAC6210
C9J172C9J172_HUMANHDAC6142
A0A2R8Y6Z9A0A2R8Y6Z9_HUMANHDAC6669
A0A2R8Y758A0A2R8Y758_HUMANHDAC6211
A0A2R8Y5Z4A0A2R8Y5Z4_HUMANHDAC691
A0A2R8Y559A0A2R8Y559_HUMANHDAC61192
E7EP63E7EP63_HUMANHDAC6167
E7ER52E7ER52_HUMANHDAC6171
A0A2R8YDE6A0A2R8YDE6_HUMANHDAC61160
A0A2R8YCS4A0A2R8YCS4_HUMANHDAC6893
A0A8V8TM63A0A8V8TM63_HUMANHDAC6921
A0A8V8TMA5A0A8V8TMA5_HUMANHDAC61108
A0A8V8TL08A0A8V8TL08_HUMANHDAC61166
A0A8V8TKY7A0A8V8TKY7_HUMANHDAC61211
Q9BRX7Q9BRX7_HUMANHDAC6146

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias1-34Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AC231533
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.

Genome annotation databases

Similar Proteins

Disclaimer

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