A0A8V8TKS0 · A0A8V8TKS0_HUMAN

  • Protein
    C-1-tetrahydrofolate synthase, cytoplasmic
  • Gene
    MTHFD1
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    3/5

Function

Catalytic activity

Pathway

One-carbon metabolism; tetrahydrofolate interconversion.

GO annotations

AspectTerm
Molecular FunctionATP binding
Molecular Functionformate-tetrahydrofolate ligase activity
Molecular Functionmethylenetetrahydrofolate dehydrogenase (NADP+) activity
Biological Processone-carbon metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

Gene names

    • Name
      MTHFD1

Organism names

  • Taxonomic identifier
  • Organism
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    A0A8V8TKS0

Proteomes

Organism-specific databases

Disease & Variants

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 679 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Genetic variation databases

PTM/Processing

Features

Showing features for modified residue (large scale data).

TypeIDPosition(s)SourceDescription
Modified residue (large scale data)237PRIDEPhosphoserine
Modified residue (large scale data)409PRIDEPhosphoserine

Proteomic databases

Interaction

Subunit

Homodimer.

Structure

3D structure databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain2-44Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic
Domain48-212Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding

Sequence similarities

In the C-terminal section; belongs to the formate--tetrahydrofolate ligase family.
In the N-terminal section; belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    762
  • Mass (Da)
    82,593
  • Last updated
    2022-12-14 v1
  • Checksum
    DBAB75E028DD271E
MKYITSLNEDSTVHGFLVQLPLDSENSINTEEVINAIAPEKDVDGLTSINAGKLARGDLNDCFIPCTPKGCLELIKETGVPIAGRHAVVVGRSKIVGAPMHDLLLWNNATVTTCHSKTAHLDEEVNKGDILVVATGQPEMVKGEWIKPGAIVIDCGINYVPDDKKPNGRKVVGDVAYDEAKERASFITPVPGGVGPMTVAMLMQSTVESAKRFLEKFKPGKWMIQYNNLNLKTPVPSDIDISRSCKPKPIGKLAREIGLLSEEVELYGETKAKVLLSALERLKHRPDGKYVVVTGITPTPLGEGKSTTTIGLVQALGAHLYQNVFACVRQPSQGPTFGIKGGAAGGGYSQVIPMEEFNLHLTGDIHAITAANNLVAAAIDARIFHELTQTDKALFNRLVPSVNGVRRFSDIQIRRLKRLGIEKTDPTTLTDEEINRFARLDIDPETITWQRVLDTNDRFLRKITIGQAPTEKGHTRTAQFDISVASEIMAVLALTTSLEDMRERLGKMVVASSKKGEPVSAEDLGVSGALTVLMKDAIKPNLMQTLEGTPVFVHAGPFANIAHGNSSIIADRIALKLVGPEGFVVTEAGFGADIGMEKFFNIKCRYSGLCPHVVVLVATVRALKMHGGGPTVTAGLPLPKAYIQENLELVEKGFSNLKKQIENARMFGIPVVVAVNAFNSQLRIKSGSLHRRSMEQMTLNYFPKLNTKLKSTRSRALGISPSAWLKHTCLCLTTQSKKVSLQASFCPFATSAPALGLVFCTP

Computationally mapped potential isoform sequences

There are 13 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
P11586C1TC_HUMANMTHFD1935
V9GZ32V9GZ32_HUMANMTHFD123
V9GZ78V9GZ78_HUMANMTHFD1854
V9GYY3V9GYY3_HUMANMTHFD1922
A0A494C1T2A0A494C1T2_HUMANMTHFD1644
A0A8V8TMA4A0A8V8TMA4_HUMANMTHFD1884
A0A8V8TMA9A0A8V8TMA9_HUMANMTHFD1356
A0A8V8TKR5A0A8V8TKR5_HUMANMTHFD1628
A0A8V8TKT4A0A8V8TKT4_HUMANMTHFD1906
A0A8V8TL46A0A8V8TL46_HUMANMTHFD1392
A0A8V8TL50A0A8V8TL50_HUMANMTHFD1852
A0A8C8UXK2A0A8C8UXK2_HUMANMTHFD1161
F5H2F4F5H2F4_HUMANMTHFD1964

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AL122035
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.

Genome annotation databases

Similar Proteins

Disclaimer

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