A0A8V8TKS0 · A0A8V8TKS0_HUMAN
- ProteinC-1-tetrahydrofolate synthase, cytoplasmic
- GeneMTHFD1
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids762 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score3/5
Function
Catalytic activity
- (6R)-5,10-methenyltetrahydrofolate + H2O = (6R)-10-formyltetrahydrofolate + H+
Pathway
One-carbon metabolism; tetrahydrofolate interconversion.
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | ATP binding | |
Molecular Function | formate-tetrahydrofolate ligase activity | |
Molecular Function | methylenetetrahydrofolate dehydrogenase (NADP+) activity | |
Biological Process | one-carbon metabolic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameC-1-tetrahydrofolate synthase, cytoplasmic
- EC number
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionA0A8V8TKS0
Proteomes
Organism-specific databases
Disease & Variants
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 679 variants from UniProt as well as other sources including ClinVar and dbSNP.
Genetic variation databases
PTM/Processing
Features
Showing features for modified residue (large scale data).
Type | ID | Position(s) | Source | Description | |||
---|---|---|---|---|---|---|---|
Modified residue (large scale data) | 237 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 409 | PRIDE | Phosphoserine | ||||
Sequence: S |
Proteomic databases
Interaction
Subunit
Homodimer.
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 2-44 | Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic | ||||
Sequence: KYITSLNEDSTVHGFLVQLPLDSENSINTEEVINAIAPEKDVD | ||||||
Domain | 48-212 | Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding | ||||
Sequence: SINAGKLARGDLNDCFIPCTPKGCLELIKETGVPIAGRHAVVVGRSKIVGAPMHDLLLWNNATVTTCHSKTAHLDEEVNKGDILVVATGQPEMVKGEWIKPGAIVIDCGINYVPDDKKPNGRKVVGDVAYDEAKERASFITPVPGGVGPMTVAMLMQSTVESAKR |
Sequence similarities
In the C-terminal section; belongs to the formate--tetrahydrofolate ligase family.
In the N-terminal section; belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length762
- Mass (Da)82,593
- Last updated2022-12-14 v1
- ChecksumDBAB75E028DD271E
Computationally mapped potential isoform sequences
There are 13 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
P11586 | C1TC_HUMAN | MTHFD1 | 935 | ||
V9GZ32 | V9GZ32_HUMAN | MTHFD1 | 23 | ||
V9GZ78 | V9GZ78_HUMAN | MTHFD1 | 854 | ||
V9GYY3 | V9GYY3_HUMAN | MTHFD1 | 922 | ||
A0A494C1T2 | A0A494C1T2_HUMAN | MTHFD1 | 644 | ||
A0A8V8TMA4 | A0A8V8TMA4_HUMAN | MTHFD1 | 884 | ||
A0A8V8TMA9 | A0A8V8TMA9_HUMAN | MTHFD1 | 356 | ||
A0A8V8TKR5 | A0A8V8TKR5_HUMAN | MTHFD1 | 628 | ||
A0A8V8TKT4 | A0A8V8TKT4_HUMAN | MTHFD1 | 906 | ||
A0A8V8TL46 | A0A8V8TL46_HUMAN | MTHFD1 | 392 | ||
A0A8V8TL50 | A0A8V8TL50_HUMAN | MTHFD1 | 852 | ||
A0A8C8UXK2 | A0A8C8UXK2_HUMAN | MTHFD1 | 161 | ||
F5H2F4 | F5H2F4_HUMAN | MTHFD1 | 964 |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AL122035 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. |