A0A8V0XWK1 · A0A8V0XWK1_CHICK
- ProteinN-acetylgalactosamine-6-sulfatase
- GeneGALNS
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids497 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score3/5
Function
Catalytic activity
Cofactor
Note: Binds 1 Ca2+ ion per subunit.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 29 | Ca2+ (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 30 | Ca2+ (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Active site | 69 | Nucleophile | ||||
Sequence: C | ||||||
Binding site | 69 | Ca2+ (UniProtKB | ChEBI); via 3-oxoalanine | ||||
Sequence: C | ||||||
Active site | 132 | |||||
Sequence: H | ||||||
Binding site | 279 | Ca2+ (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 280 | Ca2+ (UniProtKB | ChEBI) | ||||
Sequence: N |
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | lysosome | |
Molecular Function | metal ion binding | |
Molecular Function | N-acetylgalactosamine-6-sulfatase activity |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameN-acetylgalactosamine-6-sulfatase
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Archelosauria > Archosauria > Dinosauria > Saurischia > Theropoda > Coelurosauria > Aves > Neognathae > Galloanserae > Galliformes > Phasianidae > Phasianinae > Gallus
Accessions
- Primary accessionA0A8V0XWK1
Proteomes
Subcellular Location
PTM/Processing
Features
Showing features for signal, chain, modified residue, glycosylation.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-18 | |||||
Sequence: MARAVLVPLWLCWALGCA | ||||||
Chain | PRO_5036492465 | 19-497 | N-acetylgalactosamine-6-sulfatase | |||
Sequence: APPNVVLLLMDDMGWGDLGAFGEPSKETPNLDQMASEGMLFLDFYAANPLCSPSRAALLTGRLPVRNGFYTTNAHARNAYTPQDIVGGIQDSEILLPELLKKAGYTNKIIGKWHLGHRPQFHPLKHGFDEWFGSPNCHFGPYDNRALPNIPVYRDWEMIGRYYEDFKIDLRTGEANLTQIYLQEALDFISKQQASQQPFFLYWAIDATHAPVYASKHFLGTSQRGRYGDAVREIDDSVGKILKHLQKLGISENTFVFFTSDNGAALISAPKQGGSNGPFLCGKQTTFEGGMREPAIAWWPGHIPAGSVSRQLGSVMDLFTTSLSLVGLQPPSDRQIDGIDLLPAILQGKLIDRPIFYYRGNEMMAVRVGLYKAHYWTWSNSWEDYSKGIDFCPGQNVSGVTTHLQEEHSTLPLLFHLGRDPGEKYPLSFASDEYQGVMRRISAVVQQHKDTMVPGVPQLNVCDKAVMELELALLRREML | ||||||
Modified residue | 69 | 3-oxoalanine (Cys) | ||||
Sequence: C | ||||||
Glycosylation | 194 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 414 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N |
Interaction
Subunit
Homodimer.
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 21-345 | Sulfatase N-terminal | ||||
Sequence: PNVVLLLMDDMGWGDLGAFGEPSKETPNLDQMASEGMLFLDFYAANPLCSPSRAALLTGRLPVRNGFYTTNAHARNAYTPQDIVGGIQDSEILLPELLKKAGYTNKIIGKWHLGHRPQFHPLKHGFDEWFGSPNCHFGPYDNRALPNIPVYRDWEMIGRYYEDFKIDLRTGEANLTQIYLQEALDFISKQQASQQPFFLYWAIDATHAPVYASKHFLGTSQRGRYGDAVREIDDSVGKILKHLQKLGISENTFVFFTSDNGAALISAPKQGGSNGPFLCGKQTTFEGGMREPAIAWWPGHIPAGSVSRQLGSVMDLFTTSLSLVG |
Sequence similarities
Belongs to the sulfatase family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length497
- Mass (Da)55,570
- Last updated2022-12-14 v1
- ChecksumACADF37E333605C3
Computationally mapped potential isoform sequences
There are 6 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A8V0XWJ8 | A0A8V0XWJ8_CHICK | GALNS | 547 | ||
A0A8V0XUL7 | A0A8V0XUL7_CHICK | GALNS | 478 | ||
A0A8V0Y2M5 | A0A8V0Y2M5_CHICK | GALNS | 498 | ||
A0A8V0Y2M9 | A0A8V0Y2M9_CHICK | GALNS | 488 | ||
A0A8V0XQ94 | A0A8V0XQ94_CHICK | GALNS | 505 | ||
A0A1D5PM49 | A0A1D5PM49_CHICK | GALNS | 513 |
Keywords
- Technical term