A0A8V0XWK1 · A0A8V0XWK1_CHICK

  • Protein
    N-acetylgalactosamine-6-sulfatase
  • Gene
    GALNS
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    3/5

Function

Catalytic activity

  • Hydrolysis of the 6-sulfate groups of the N-acetyl-D-galactosamine 6-sulfate units of chondroitin sulfate and of the D-galactose 6-sulfate units of keratan sulfate.
    EC:3.1.6.4 (UniProtKB | ENZYME | Rhea)

Cofactor

Ca2+ (UniProtKB | Rhea| CHEBI:29108 )

Note: Binds 1 Ca2+ ion per subunit.

Features

Showing features for binding site, active site.

149750100150200250300350400450
TypeIDPosition(s)Description
Binding site29Ca2+ (UniProtKB | ChEBI)
Binding site30Ca2+ (UniProtKB | ChEBI)
Active site69Nucleophile
Binding site69Ca2+ (UniProtKB | ChEBI); via 3-oxoalanine
Active site132
Binding site279Ca2+ (UniProtKB | ChEBI)
Binding site280Ca2+ (UniProtKB | ChEBI)

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentlysosome
Molecular Functionmetal ion binding
Molecular FunctionN-acetylgalactosamine-6-sulfatase activity

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    N-acetylgalactosamine-6-sulfatase
  • EC number
  • Alternative names
    • Chondroitinsulfatase
    • Galactose-6-sulfate sulfatase
    • N-acetylgalactosamine-6-sulfate sulfatase

Gene names

    • Name
      GALNS

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • Broiler
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Archelosauria > Archosauria > Dinosauria > Saurischia > Theropoda > Coelurosauria > Aves > Neognathae > Galloanserae > Galliformes > Phasianidae > Phasianinae > Gallus

Accessions

  • Primary accession
    A0A8V0XWK1

Proteomes

Subcellular Location

Keywords

  • Cellular component

PTM/Processing

Features

Showing features for signal, chain, modified residue, glycosylation.

TypeIDPosition(s)Description
Signal1-18
ChainPRO_503649246519-497N-acetylgalactosamine-6-sulfatase
Modified residue693-oxoalanine (Cys)
Glycosylation194N-linked (GlcNAc...) asparagine
Glycosylation414N-linked (GlcNAc...) asparagine

Interaction

Subunit

Homodimer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain21-345Sulfatase N-terminal

Sequence similarities

Belongs to the sulfatase family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    497
  • Mass (Da)
    55,570
  • Last updated
    2022-12-14 v1
  • Checksum
    ACADF37E333605C3
MARAVLVPLWLCWALGCAAPPNVVLLLMDDMGWGDLGAFGEPSKETPNLDQMASEGMLFLDFYAANPLCSPSRAALLTGRLPVRNGFYTTNAHARNAYTPQDIVGGIQDSEILLPELLKKAGYTNKIIGKWHLGHRPQFHPLKHGFDEWFGSPNCHFGPYDNRALPNIPVYRDWEMIGRYYEDFKIDLRTGEANLTQIYLQEALDFISKQQASQQPFFLYWAIDATHAPVYASKHFLGTSQRGRYGDAVREIDDSVGKILKHLQKLGISENTFVFFTSDNGAALISAPKQGGSNGPFLCGKQTTFEGGMREPAIAWWPGHIPAGSVSRQLGSVMDLFTTSLSLVGLQPPSDRQIDGIDLLPAILQGKLIDRPIFYYRGNEMMAVRVGLYKAHYWTWSNSWEDYSKGIDFCPGQNVSGVTTHLQEEHSTLPLLFHLGRDPGEKYPLSFASDEYQGVMRRISAVVQQHKDTMVPGVPQLNVCDKAVMELELALLRREML

Computationally mapped potential isoform sequences

There are 6 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A8V0XWJ8A0A8V0XWJ8_CHICKGALNS547
A0A8V0XUL7A0A8V0XUL7_CHICKGALNS478
A0A8V0Y2M5A0A8V0Y2M5_CHICKGALNS498
A0A8V0Y2M9A0A8V0Y2M9_CHICKGALNS488
A0A8V0XQ94A0A8V0XQ94_CHICKGALNS505
A0A1D5PM49A0A1D5PM49_CHICKGALNS513

Keywords

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp