A0A8T6ZFB0 · A0A8T6ZFB0_9BURK
- ProteinCarnitine monooxygenase oxygenase subunit
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids382 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Converts carnitine to trimethylamine and malic semialdehyde.
Catalytic activity
- (R)-carnitine + NADH + O2 + H+ = (3R)-3-hydroxy-4-oxobutanoate + trimethylamine + NAD+ + H2O
Cofactor
Protein has several cofactor binding sites:
Note: Binds 1 Fe cation per subunit.
Note: Binds 1 [2Fe-2S] cluster per subunit.
Pathway
Amine and polyamine metabolism; carnitine metabolism.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 96 | [2Fe-2S] cluster (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 98 | [2Fe-2S] cluster (UniProtKB | ChEBI) | ||||
Sequence: H | ||||||
Binding site | 116 | [2Fe-2S] cluster (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 119 | [2Fe-2S] cluster (UniProtKB | ChEBI) | ||||
Sequence: H | ||||||
Binding site | 218 | Fe cation (UniProtKB | ChEBI) | ||||
Sequence: H | ||||||
Binding site | 223 | Fe cation (UniProtKB | ChEBI) | ||||
Sequence: H | ||||||
Binding site | 333 | Fe cation (UniProtKB | ChEBI) | ||||
Sequence: D |
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | 2 iron, 2 sulfur cluster binding | |
Molecular Function | iron ion binding | |
Molecular Function | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen | |
Biological Process | carnitine metabolic process | |
Biological Process | catabolic process |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameCarnitine monooxygenase oxygenase subunit
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Betaproteobacteria > Burkholderiales > Burkholderiaceae > Paraburkholderia
Accessions
- Primary accessionA0A8T6ZFB0
Proteomes
Interaction
Subunit
Composed of an oxygenase subunit and a reductase subunit.
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 54-162 | Rieske | ||||
Sequence: WICVAHRSELAETNAYVTREVVGESILLVRGKDKVLRAFYNVCPHRGHQLLEGSGKAKNVITCPYHAWAFKLDGALAHANNCDHVESFDKENSTLVPVRVEEYAGFVFI |
Sequence similarities
Family and domain databases
Sequence
- Sequence statusComplete
- Length382
- Mass (Da)43,471
- Last updated2022-10-12 v1
- ChecksumF4638BAA9F7039E4
Keywords
- Technical term