A0A8T6Z9L5 · A0A8T6Z9L5_9BURK
- ProteinCytochrome c oxidase subunit 2
- GenecoxB
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids543 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B).
Catalytic activity
- 4 Fe(II)-[cytochrome c] + O2 + 8 H+(in) = 4 Fe(III)-[cytochrome c] + 2 H2O + 4 H+(out)
4 RHEA-COMP:10350 + CHEBI:15379 + 8 H+ (in)CHEBI:15378= 4 RHEA-COMP:14399 + 2 CHEBI:15377 + 4 H+ (out)CHEBI:15378
Cofactor
Note: Binds a copper A center.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | periplasmic space | |
Cellular Component | plasma membrane | |
Molecular Function | copper ion binding | |
Molecular Function | cytochrome-c oxidase activity | |
Molecular Function | heme binding | |
Biological Process | ATP synthesis coupled electron transport |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameCytochrome c oxidase subunit 2
- EC number
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Betaproteobacteria > Burkholderiales > Burkholderiaceae > Paraburkholderia
Accessions
- Primary accessionA0A8T6Z9L5
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Multi-pass membrane protein
Membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Transmembrane | 59-86 | Helical | |||
Transmembrane | 107-125 | Helical | |||
Keywords
- Cellular component
PTM/Processing
Features
Showing features for signal, chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Signal | 1-33 | ||||
Chain | PRO_5035842010 | 34-543 | Cytochrome c oxidase subunit 2 | ||
Structure
Family & Domains
Features
Showing features for domain, region.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 40-135 | Cytochrome oxidase subunit II transmembrane region profile | |||
Domain | 136-276 | Cytochrome oxidase subunit II copper A binding | |||
Domain | 296-373 | Cytochrome c | |||
Region | 389-420 | Disordered | |||
Domain | 434-543 | OmpA-like | |||
Sequence similarities
Belongs to the cytochrome c oxidase subunit 2 family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length543
- Mass (Da)57,484
- Last updated2022-10-12 v1
- MD5 ChecksumCB6167EE9BD815486A61B35235206C71
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
JTDB02000002 EMBL· GenBank· DDBJ | NLP61332.1 EMBL· GenBank· DDBJ | Genomic DNA |