A0A8T6RI89 · A0A8T6RI89_9ARCH
- ProteinK(+)-insensitive pyrophosphate-energized proton pump
- GenehppA
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids722 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force.
Catalytic activity
- diphosphate + H+(in) + H2O = 2 H+(out) + 2 phosphate
Cofactor
Features
Showing features for site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Site | 489 | Determinant of potassium independence | ||||
Sequence: K |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | plasma membrane | |
Molecular Function | diphosphate hydrolysis-driven proton transmembrane transporter activity | |
Molecular Function | inorganic diphosphate phosphatase activity | |
Molecular Function | magnesium ion binding |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameK(+)-insensitive pyrophosphate-energized proton pump
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageArchaea > Asgard group > Candidatus Lokiarchaeota
Accessions
- Primary accessionA0A8T6RI89
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Multi-pass membrane protein
Membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 6-28 | Helical | ||||
Sequence: SLVFLILGAIGGIISIGFAFYLW | ||||||
Transmembrane | 60-78 | Helical | ||||
Sequence: FKTIFAIAGILSIIIFFAL | ||||||
Transmembrane | 90-113 | Helical | ||||
Sequence: FVFLSFWIGTITSLAASFIGMDIA | ||||||
Transmembrane | 141-165 | Helical | ||||
Sequence: IMGMLVFGVNVIQIVITYLFLYMIF | ||||||
Transmembrane | 171-190 | Helical | ||||
Sequence: AIVVNIVGCAFGGSFTSVIA | ||||||
Transmembrane | 274-296 | Helical | ||||
Sequence: VIFFPFLIRFIATIATIIGYFFV | ||||||
Transmembrane | 317-336 | Helical | ||||
Sequence: LYLSSSIIAVIYVLLVLLIF | ||||||
Transmembrane | 342-362 | Helical | ||||
Sequence: VFAAIFGIAANLIMGFIFEYF | ||||||
Transmembrane | 396-420 | Helical | ||||
Sequence: VFIPLSIIAMMILGAFGFGALFGVF | ||||||
Transmembrane | 426-449 | Helical | ||||
Sequence: FILGGTYGIVIMSMGMTSGTGIIL | ||||||
Transmembrane | 494-512 | Helical | ||||
Sequence: GFSIISGTTIGFVTIFAYI | ||||||
Transmembrane | 524-552 | Helical | ||||
Sequence: AMINMGFVNVAVGGIFGVITVFLFVSLLM | ||||||
Transmembrane | 600-619 | Helical | ||||
Sequence: MIFPALLIIIMPIAVGIFLG | ||||||
Transmembrane | 625-648 | Helical | ||||
Sequence: AFLIIATFTGGAMGIFMNVSGASW | ||||||
Transmembrane | 701-720 | Helical | ||||
Sequence: LAITFFPLFVFTYGIALHFI |
Keywords
- Cellular component
Interaction
Subunit
Homodimer.
Structure
Family & Domains
Sequence similarities
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length722
- Mass (Da)77,263
- Last updated2022-10-12 v1
- Checksum989D24B1B9D401C8