A0A8T5IC00 · A0A8T5IC00_UNCEA

  • Protein
    NAD-dependent protein deacylase
  • Gene
    cobB
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form. Deacetylates the N-terminal lysine residue of Alba, the major archaeal chromatin protein and that, in turn, increases Alba's DNA binding affinity, thereby repressing transcription.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Features

Showing features for active site, binding site.

TypeIDPosition(s)Description
Active site113Nucleophile
Active site205
Active site207
Binding site259-278NAD+ (UniProtKB | ChEBI)
Binding site303substrate
Binding site306substrate
Binding site337-340NAD+ (UniProtKB | ChEBI)
Active site355Proton acceptor
Binding site423-425NAD+ (UniProtKB | ChEBI)
Binding site449-451NAD+ (UniProtKB | ChEBI)
Binding site467NAD+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular FunctionNAD+ binding
Molecular FunctionNAD-dependent histone deacetylase activity
Molecular Functionprotein-malonyllysine demalonylase activity
Molecular Functionprotein-succinyllysine desuccinylase activity
Molecular Functiontransferase activity
Biological Processglutamine metabolic process
Biological Processprotein deacetylation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    NAD-dependent protein deacylase
  • EC number
  • Alternative names
    • Regulatory protein SIR2 homolog

Gene names

    • Name
      cobB
    • ORF names
      HOA04_00245

Organism names

Accessions

  • Primary accession
    A0A8T5IC00

Proteomes

Subcellular Location

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain233-481Deacetylase sirtuin-type

Domain

2 residues (Tyr-303 and Arg-306) present in a large hydrophobic pocket are probably involved in substrate specificity. They are important for desuccinylation activity, but dispensable for deacetylation activity.

Sequence similarities

Belongs to the sirtuin family. Class III subfamily.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    484
  • Mass (Da)
    53,763
  • Last updated
    2022-10-12 v1
  • Checksum
    233B6934DD1B866A
MAARLVILDLLCEKEVYGPKGNAAALGVFGDDLEVLALTPQAPELTGEGEWDGLPFQRIPMPTEITSFLEQGIDALVISGSRSNITQPEEWMEGCASFVRQVVEYGVPTLGICFGHQLLAHAFGGELERQSKSFNDISSIKLLQADKLFEGCNESPKVIFTHQDQVVSLPQRLKLLASAVHAPIAAFRIHTEEGIPMKAWGVQFHPESTPEICRYASSVGDMPFAEGDARIEELAGSNILQNFARLALNKTPRVVVLTGAGISAESGLKTFRDNDGLWENHRLEDVASPIAWRRDPELVWRFYQARRRQLLEAEPNSAHYALAELENKVDSFTLITQNVDDLHSRAGSKNMVQMHGQLRLLRCEACYEIFEKMQTEDLEDDFITCQCEKGILRPHIVWFGEEPLGMMRIKRETMAADIFIVIGTSGVVYPANSLLPIAKSNGAYCIGVNLEAPGNVELFDEFHQGKAGEVLPELVEKLLQEWSS

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JABHOI010000011
EMBL· GenBank· DDBJ
MBT6971515.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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