A0A8T5EKM4 · A0A8T5EKM4_UNCEA

Function

function

Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

  • Endonucleolytic cleavage of RNA, removing extra 3' nucleotides from tRNA precursor, generating 3' termini of tRNAs. A 3'-hydroxy group is left at the tRNA terminus and a 5'-phosphoryl group is left at the trailer molecule.
    EC:3.1.26.11 (UniProtKB | ENZYME | Rhea)

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 2 Zn2+ ions.

Features

Showing features for binding site, active site.

Type
IDPosition(s)Description
Binding site73Zn2+ 1 (UniProtKB | ChEBI); catalytic
Binding site75Zn2+ 1 (UniProtKB | ChEBI); catalytic
Active site77Proton acceptor
Binding site77Zn2+ 2 (UniProtKB | ChEBI); catalytic
Binding site78Zn2+ 2 (UniProtKB | ChEBI); catalytic
Binding site199Zn2+ 1 (UniProtKB | ChEBI); catalytic
Binding site284Zn2+ 1 (UniProtKB | ChEBI); catalytic
Binding site284Zn2+ 2 (UniProtKB | ChEBI); catalytic
Binding site345Zn2+ 2 (UniProtKB | ChEBI); catalytic

GO annotations

AspectTerm
Molecular Function3'-tRNA processing endoribonuclease activity
Molecular Functionzinc ion binding

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Ribonuclease Z
  • EC number
  • Short names
    RNase Z
  • Alternative names
    • tRNA 3 endonuclease
    • tRNase Z

Gene names

    • Name
      rnz
    • ORF names
      HOE92_08090

Organism names

Accessions

  • Primary accession
    A0A8T5EKM4

Proteomes

Interaction

Subunit

Homodimer.

Family & Domains

Sequence similarities

Belongs to the RNase Z family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    401
  • Mass (Da)
    43,777
  • Last updated
    2022-10-12 v1
  • MD5 Checksum
    441F0A475FA12F20F54F1E8057A82E02
MELEAHLLGTSSARPANGREVSGSIVIVGKYQIAIDAGEGFQTRLKKQAKVLKNAKWESRISHTRLDVIALTHGHLDHCWGVLPMLLSMGLDCRNSPLSVLAPLHHDAYHALAKDGMDAKMPDSVPAVDLINQMRFWWELLFDKISSEEMFPIFWYTVSWIDGEEKWLQLDPQNSTVSQLSAPPKPIGPHSLTPHQTIHSVPSCGWRITSADRPGKFNAQRSAELSLSDNQISKLANGEDITIIATSDASSSAPSANSAANEILLASDFRGPSTSGVSILITGDTGAEAPELLALAKAAPLNLLIHESTYSDSHQSNAINYLHSTSRDAAKVATQIAAENLVLTHYSSRFVETEIPLTEAREAHPRVHAGEDGDIFQIERDGSLKIFRISDGSPFQILEPF

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JABIHC010000176
EMBL· GenBank· DDBJ
MBT3972161.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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