A0A8T4XKL3 · A0A8T4XKL3_9ARCH

Function

function

Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Binds 1 Mg2+ ion per subunit.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site15-20substrate
Binding site44Mg2+ (UniProtKB | ChEBI)
Active site73Proton acceptor
Binding site73Mg2+ (UniProtKB | ChEBI)
Binding site74substrate
Binding site149-152substrate
Binding site173substrate
Binding site178-179substrate

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Functionmetal ion binding
Molecular Functionnucleoside triphosphate diphosphatase activity
Molecular Functionnucleotide binding
Molecular Functionribonucleoside triphosphate phosphatase activity
Biological Processnucleotide metabolic process
Biological Processpurine nucleoside triphosphate catabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    dITP/XTP pyrophosphatase
  • EC number
  • Alternative names
    • Non-canonical purine NTP pyrophosphatase
    • Non-standard purine NTP pyrophosphatase
    • Nucleoside-triphosphate diphosphatase
    • Nucleoside-triphosphate pyrophosphatase
      (NTPase
      )

Gene names

    • ORF names
      KEJ14_02755

Organism names

Accessions

  • Primary accession
    A0A8T4XKL3

Proteomes

Subcellular Location

Interaction

Subunit

Homodimer.

Family & Domains

Sequence similarities

Belongs to the HAM1 NTPase family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    195
  • Mass (Da)
    21,990
  • Last updated
    2022-10-12 v1
  • Checksum
    FE88693ACD2DF619
MNKNFPYGRLIFFVTENAHKFNEARSVLAEYNVAVAMIKMRTLEVQDDDIENIARIRVLQAVREVNLPVIVEDAGLFIDALGGFPGPYSSYVYRKIGLGGILKLLNGVNDRSAKFKSVVAFCDPNNNLKCFHGIVEGRISLEARGSGGFGFDPIFEPNESPGKTFGEMTTEEKCRFSHRARALREFAKWYRSWQA

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JAGTQF010000007
EMBL· GenBank· DDBJ
MBS7606745.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp