A0A8T3X464 · A0A8T3X464_9ARCH

Function

function

Essential for tRNA splicing and maturation. Acts by directly joining spliced tRNA halves to mature-sized tRNAs. Joins RNA with 2',3'-cyclic-phosphate or 3'-phosphate ends to RNA with 5'-hydroxy ends.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

Note: Binds 2 manganese ions per subunit.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site3Mn2+ 2 (UniProtKB | ChEBI)
Binding site3-4GMP (UniProtKB | ChEBI)
Binding site52-55GMP (UniProtKB | ChEBI)
Binding site59GMP (UniProtKB | ChEBI)
Active site78GMP-histidine intermediate
Binding site78-81GMP (UniProtKB | ChEBI)
Binding site154GMP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular FunctionGTP binding
Molecular Functionmetal ion binding
Molecular FunctionRNA ligase (ATP) activity
Biological ProcessRNA processing

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    tRNA-splicing ligase RtcB
  • EC number
  • Alternative names
    • 3'-phosphate/5'-hydroxy nucleic acid ligase

Gene names

    • ORF names
      HYV84_02995

Organism names

Accessions

  • Primary accession
    A0A8T3X464

Proteomes

Interaction

Subunit

Monomer.

Family & Domains

Features

Showing features for region, compositional bias.

TypeIDPosition(s)Description
Region71-98Disordered
Compositional bias76-92Polar residues

Sequence similarities

Belongs to the RtcB family.

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    155
  • Mass (Da)
    16,867
  • Last updated
    2022-10-12 v1
  • Checksum
    84134660295E1C29
VAHNTAKLEEYTVDGKKKKLIVHRKGATRSFGPGHSELIPIYEKYGQPVIIGGSMETGSYLLAGTKKAEEETFGSTAHGSGRTMSRNQAKHQWRGEQLQRDMEKRGIYVRTTTFSGLAEEAGGAYKDVDAVIMAAEEAGISRRVAKLVPMGNVKG

Features

Showing features for non-terminal residue, compositional bias.

TypeIDPosition(s)Description
Non-terminal residue1
Compositional bias76-92Polar residues

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JACPII010000033
EMBL· GenBank· DDBJ
MBI2576154.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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