A0A8T3V0F2 · A0A8T3V0F2_9EURY
- ProteinNAD kinase
- GenenadK
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids619 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
Catalytic activity
- ATP + NAD+ = ADP + H+ + NADP+
Cofactor
Protein has several cofactor binding sites:
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 73 | Mg2+ 1 (UniProtKB | ChEBI); catalytic | ||||
Sequence: E | ||||||
Binding site | 112 | Mg2+ 1 (UniProtKB | ChEBI); catalytic | ||||
Sequence: D | ||||||
Binding site | 114 | Mg2+ 1 (UniProtKB | ChEBI); catalytic | ||||
Sequence: I | ||||||
Binding site | 115 | Mg2+ 1 (UniProtKB | ChEBI); catalytic | ||||
Sequence: D | ||||||
Binding site | 241 | Mg2+ 1 (UniProtKB | ChEBI); catalytic | ||||
Sequence: D | ||||||
Active site | 399 | Proton acceptor | ||||
Sequence: D | ||||||
Binding site | 399-400 | NAD+ (UniProtKB | ChEBI) | ||||
Sequence: DG | ||||||
Binding site | 404 | NAD+ (UniProtKB | ChEBI) | ||||
Sequence: R | ||||||
Binding site | 467-468 | NAD+ (UniProtKB | ChEBI) | ||||
Sequence: NE | ||||||
Binding site | 478 | NAD+ (UniProtKB | ChEBI) | ||||
Sequence: K | ||||||
Binding site | 495 | NAD+ (UniProtKB | ChEBI) | ||||
Sequence: R | ||||||
Binding site | 497 | NAD+ (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 508-513 | NAD+ (UniProtKB | ChEBI) | ||||
Sequence: TAYAMS | ||||||
Binding site | 567 | NAD+ (UniProtKB | ChEBI) | ||||
Sequence: Q |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | ATP binding | |
Molecular Function | metal ion binding | |
Molecular Function | NAD+ kinase activity | |
Biological Process | NAD metabolic process | |
Biological Process | NADP biosynthetic process |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameNAD kinase
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageArchaea > Euryarchaeota > Methanomada group > Methanobacteria > Methanobacteriales > Methanobacteriaceae > Methanobrevibacter
Accessions
- Primary accessionA0A8T3V0F2
Proteomes
Subcellular Location
Structure
Sequence
- Sequence statusComplete
- Length619
- Mass (Da)68,805
- Last updated2022-10-12 v1
- Checksum89011C7F617232C2