A0A8T3V0F2 · A0A8T3V0F2_9EURY

Function

function

Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

a divalent metal cation (UniProtKB | Rhea| CHEBI:60240 )

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site73Mg2+ 1 (UniProtKB | ChEBI); catalytic
Binding site112Mg2+ 1 (UniProtKB | ChEBI); catalytic
Binding site114Mg2+ 1 (UniProtKB | ChEBI); catalytic
Binding site115Mg2+ 1 (UniProtKB | ChEBI); catalytic
Binding site241Mg2+ 1 (UniProtKB | ChEBI); catalytic
Active site399Proton acceptor
Binding site399-400NAD+ (UniProtKB | ChEBI)
Binding site404NAD+ (UniProtKB | ChEBI)
Binding site467-468NAD+ (UniProtKB | ChEBI)
Binding site478NAD+ (UniProtKB | ChEBI)
Binding site495NAD+ (UniProtKB | ChEBI)
Binding site497NAD+ (UniProtKB | ChEBI)
Binding site508-513NAD+ (UniProtKB | ChEBI)
Binding site567NAD+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular FunctionATP binding
Molecular Functionmetal ion binding
Molecular FunctionNAD+ kinase activity
Biological ProcessNAD metabolic process
Biological ProcessNADP biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    NAD kinase
  • EC number
  • Alternative names
    • ATP-dependent NAD kinase

Gene names

    • Name
      nadK
    • ORF names
      E7Z83_02365

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • SIG22
  • Taxonomic lineage
    Archaea > Euryarchaeota > Methanomada group > Methanobacteria > Methanobacteriales > Methanobacteriaceae > Methanobrevibacter

Accessions

  • Primary accession
    A0A8T3V0F2

Proteomes

Subcellular Location

Keywords

Family & Domains

Sequence similarities

Belongs to the NAD kinase family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    619
  • Mass (Da)
    68,805
  • Last updated
    2022-10-12 v1
  • Checksum
    89011C7F617232C2
MDARDKKLATDLAYEIIKEVSRATRPYIGTPEAGEKVKMGADGTPTSLIDVISEEIVVNVLKEAPVYSYLVSEEIGELRLGKGTKRSISLTQELRRDDLSEDEKPRFIFLVDPIDGTSNAIKEIPAFAISIAVASVPDGRVATLNDVELAFISNLANGNFFEAEKGKGCWLNNKKVKPSDEVKISNMTLGGFTKSGTSQASELVDNARRMRVLGSVVLELSYVASGRYDAFLDLRGSRIIDISAAKLILEEAGGIITDKYGEKLNTTLSIYEKSIVVAANNEVLHKQMIDILNDNQTDFIGKIGVVGRIDQDRSALFSVKIIDYLLINGREVIIEKRLAQKIMELKQNPDIAKIIEKTKENYPEMRDMLDDINFNIDFEKMSRYIHEFDCDMAVILGGDGTLLRAESQMKPEIPVFGINMGTVGFLTDTEIQDTFTALDEVLRGDYYKEKRSRIVVSHENNHYSAINEVVIMTSKPAKMLHFQIKVDGEIIDEVRADGLIISTPSGSTAYAMSAGGPIMDPKVGGFLIIPICPYKLGARPFVVSDNSEIAVKLLKKGKSAVFVMDGQRNEEADYEEEIKFKKSDKDAYFIRTSTKYFYKKVKDKLGEGGVKDPNRCINE

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
SUTO01000002
EMBL· GenBank· DDBJ
MBE6489682.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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