A0A8T2BDP6 · A0A8T2BDP6_9BRAS
- ProteinE3 ubiquitin-protein ligase ORTHRUS
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids1560 (go to sequence)
- Protein existencePredicted
- Annotation score3/5
Function
function
Multi domain E3 ubiquitin ligase that also plays a role in DNA methylation and histone modifications.
Catalytic activity
Pathway
Protein modification; protein ubiquitination.
GO annotations
all annotations | all molecular function | nucleotide binding | molecular_function | nucleic acid binding | dna binding | chromatin binding | dna-binding transcription factor activity | rna binding | cytoskeletal motor activity | catalytic activity | nuclease activity | signaling receptor binding | structural molecule activity | transporter activity | binding | protein binding | translation factor activity, rna binding | lipid binding | kinase activity | transferase activity | hydrolase activity | oxygen binding | enzyme regulator activity | carbohydrate binding | signaling receptor activity | translation regulator activity | transcription regulator activity | other molecular function | all biological process | carbohydrate metabolic process | generation of precursor metabolites and energy | nucleobase-containing compound metabolic process | dna metabolic process | translation | lipid metabolic process | transport | response to stress | cell cycle | cell communication | signal transduction | cell-cell signaling | multicellular organism development | circadian rhythm | biological_process | metabolic process | catabolic process | biosynthetic process | response to light stimulus | response to external stimulus | tropism | response to biotic stimulus | response to abiotic stimulus | response to endogenous stimulus | embryo development | post-embryonic development | fruit ripening | abscission | pollination | flower development | cellular process | programmed cell death | photosynthesis | cellular component organization | cell growth | protein metabolic process | cellular homeostasis | secondary metabolic process | reproductive process | cell differentiation | protein modification process | growth | epigenetic regulation of gene expression | response to chemical | anatomical structure development | regulation of molecular function | other biological process | all cellular component | cellular_component | extracellular region | cell wall | intracellular anatomical structure | nucleus | nuclear envelope | nucleoplasm | nucleolus | cytoplasm | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | cytosol | ribosome | cytoskeleton | plasma membrane | chloroplast | plastid | thylakoid | membrane | external encapsulating structure | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | nucleus | |
Molecular Function | DNA binding | |
Molecular Function | histone binding | |
Molecular Function | ubiquitin protein ligase activity | |
Molecular Function | zinc ion binding | |
Biological Process | DNA integration | |
Biological Process | protein ubiquitination |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameE3 ubiquitin-protein ligase ORTHRUS
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > malvids > Brassicales > Brassicaceae > Camelineae > Arabidopsis
Accessions
- Primary accessionA0A8T2BDP6
Proteomes
Subcellular Location
Structure
Family & Domains
Features
Showing features for domain, region, coiled coil.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 12-63 | PHD-type | ||||
Sequence: AGVCMRCKSTPPPEESLTCGTCVTPWHVSCLSLPPKTLESTLQWVCPDCSGE | ||||||
Domain | 143-182 | RING-type | ||||
Sequence: CSICMQLLQKPVSTPCGHNACLKCFLKWMRQGNRSCGTCR | ||||||
Domain | 270-421 | YDG | ||||
Sequence: VRNQGVLVGESWKGRHTARQWGVHFPLVSGIAGQTSYGAQSVVLAGGYEDDEDHGEWFLYTGSGGRDLSTRNLRTNSVQGFDQKFEKSNEALRLSCKLGYPVRVVRSSKDIHSAYAPEGELLRYDGVYRIEKCWIKVGVQGSYKVCRFLFIR | ||||||
Domain | 518-574 | RING-type | ||||
Sequence: CQICQQVMTNPVTTPCAHNFCKACLVSKFAGKTLMRERSRGGRTLRAQKNVMKCPCC | ||||||
Region | 599-633 | Disordered | ||||
Sequence: KNQEEEDNTEHVDEGECSGTSHEEETLPVSGDAEQ | ||||||
Coiled coil | 837-864 | |||||
Sequence: LEQLILKLRVEEENRKNEKSEFSSMEAK | ||||||
Domain | 904-918 | CCHC-type | ||||
Sequence: CWVCGKPGHRAKDCR | ||||||
Domain | 1139-1309 | Integrase catalytic | ||||
Sequence: YKSVEKSNVLLGLIHSDLCDFQSTPSRGGKNYYISFIDDYSKFCQIYLIKTKDEALDMFKKFKAEVENQLDKRIKILRSDRGGEYLSNEFSEFCSTYGIIHQTTAPYTPMQNGVAERKNRTLKEMMNSMLNDSGAPSNLWGEAILTANSILNKIPHKKCDKTPYEMWKDKT |
Domain
The RING fingers are required for ubiquitin ligase activity.
The YDG domain mediates the interaction with histone H3.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,560
- Mass (Da)176,196
- Last updated2022-10-12 v1
- ChecksumE62DB7F30B002196