A0A8T2BDP6 · A0A8T2BDP6_9BRAS

Function

function

Multi domain E3 ubiquitin ligase that also plays a role in DNA methylation and histone modifications.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

  • S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N6-ubiquitinyl-[acceptor protein]-L-lysine.
    EC:2.3.2.27 (UniProtKB | ENZYME | Rhea)

Pathway

Protein modification; protein ubiquitination.

GO annotations

all annotationsall molecular functionnucleotide bindingmolecular_functionnucleic acid bindingdna bindingchromatin bindingdna-binding transcription factor activityrna bindingcytoskeletal motor activitycatalytic activitynuclease activitysignaling receptor bindingstructural molecule activitytransporter activitybindingprotein bindingtranslation factor activity, rna bindinglipid bindingkinase activitytransferase activityhydrolase activityoxygen bindingenzyme regulator activitycarbohydrate bindingsignaling receptor activitytranslation regulator activitytranscription regulator activityother molecular functionall biological processcarbohydrate metabolic processgeneration of precursor metabolites and energynucleobase-containing compound metabolic processdna metabolic processtranslationlipid metabolic processtransportresponse to stresscell cyclecell communicationsignal transductioncell-cell signalingmulticellular organism developmentcircadian rhythmbiological_processmetabolic processcatabolic processbiosynthetic processresponse to light stimulusresponse to external stimulustropismresponse to biotic stimulusresponse to abiotic stimulusresponse to endogenous stimulusembryo developmentpost-embryonic developmentfruit ripeningabscissionpollinationflower developmentcellular processprogrammed cell deathphotosynthesiscellular component organizationcell growthprotein metabolic processcellular homeostasissecondary metabolic processreproductive processcell differentiationprotein modification processgrowthepigenetic regulation of gene expressionresponse to chemicalanatomical structure developmentregulation of molecular functionother biological processall cellular componentcellular_componentextracellular regioncell wallintracellular anatomical structurenucleusnuclear envelopenucleoplasmnucleoluscytoplasmmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuscytosolribosomecytoskeletonplasma membranechloroplastplastidthylakoidmembraneexternal encapsulating structureother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentnucleus
Molecular FunctionDNA binding
Molecular Functionhistone binding
Molecular Functionubiquitin protein ligase activity
Molecular Functionzinc ion binding
Biological ProcessDNA integration
Biological Processprotein ubiquitination

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    E3 ubiquitin-protein ligase ORTHRUS
  • EC number
  • Alternative names
    • Protein VARIANT IN METHYLATION
    • RING-type E3 ubiquitin transferase ORTHRUS

Gene names

    • ORF names
      ISN45_Aa02g007360

Organism names

  • Taxonomic identifier
  • Strain
    • Allo738
  • Taxonomic lineage
    Eukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > malvids > Brassicales > Brassicaceae > Camelineae > Arabidopsis

Accessions

  • Primary accession
    A0A8T2BDP6

Proteomes

Subcellular Location

Keywords

  • Cellular component

Family & Domains

Features

Showing features for domain, region, coiled coil.

TypeIDPosition(s)Description
Domain12-63PHD-type
Domain143-182RING-type
Domain270-421YDG
Domain518-574RING-type
Region599-633Disordered
Coiled coil837-864
Domain904-918CCHC-type
Domain1139-1309Integrase catalytic

Domain

The RING fingers are required for ubiquitin ligase activity.
The YDG domain mediates the interaction with histone H3.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,560
  • Mass (Da)
    176,196
  • Last updated
    2022-10-12 v1
  • Checksum
    E62DB7F30B002196
MTRDTQFPCDPAGVCMRCKSTPPPEESLTCGTCVTPWHVSCLSLPPKTLESTLQWVCPDCSGETDALPVSGVAAGYGSVGSDLVVAIHEIEADDSLSAEEKAKKRQQLLSGKAVVDEDDEVEKKRKSKGKKPADEDVLSHFHCSICMQLLQKPVSTPCGHNACLKCFLKWMRQGNRSCGTCRSVVPESMISNPHINLSIVSAIRLARLSKRVDASTSKVVHVISNEDRPDKAFTTDRAKKLGNANASSGRIFVTIPRDHFGPITAEYDPVRNQGVLVGESWKGRHTARQWGVHFPLVSGIAGQTSYGAQSVVLAGGYEDDEDHGEWFLYTGSGGRDLSTRNLRTNSVQGFDQKFEKSNEALRLSCKLGYPVRVVRSSKDIHSAYAPEGELLRYDGVYRIEKCWIKVGVQGSYKVCRFLFIRCDNEPAPWTSDEHGDRPRPLPIVPELNMATNLFERKESPSWDFDEGEGRWRWMKPPPASRKPVNNVKDPEERKILRKAMTSTHSNTMRARLLKEFKCQICQQVMTNPVTTPCAHNFCKACLVSKFAGKTLMRERSRGGRTLRAQKNVMKCPCCPTDIAEFIQNPQVNREVAEVIEKLKNQEEEDNTEHVDEGECSGTSHEEETLPVSGDAEQPKKRIKLDIDAAVSATVVESDMKEEIDGVHTRVRIPGVDFKRWQQKMMFYLTTLNLAQCLTSEAPELPVEGDIPDEVIKASEAWSQNEFLCKNYILNALDDSLYDVYQIFQTPKELWESLEKKYKSEVASAKKFIVGKFLNFKMSDTISVVKQVEEIQIFAHELRDEDMGLNEAFLVASIIEKLPPTWKDFKIYLKHLHEDMSLEQLILKLRVEEENRKNEKSEFSSMEAKANVIEGNSSKFKGFKKNKNGKKPFIPPKGSNFKNKPQGACWVCGKPGHRAKDCRHKKEGKSVGDTSNANLVEDQFVAVVSEANMMTNSNDWWIDTGATKHVCSDASMFSMYVHGSEGEKLYMGNASTAKIEGKGKVVLKLTSGKELALMNVLHVPEIRKNLISGSLLSNKGFKMVFESDKVVLTKGGMYVGKGYLCDGLFKLNVVPIVNKNAGNSSASVYLLDSNDLWHARLGHVNYHSLNRMMNLGLLPKNNLKNHERSKCEVCVESKYSRHSYKSVEKSNVLLGLIHSDLCDFQSTPSRGGKNYYISFIDDYSKFCQIYLIKTKDEALDMFKKFKAEVENQLDKRIKILRSDRGGEYLSNEFSEFCSTYGIIHQTTAPYTPMQNGVAERKNRTLKEMMNSMLNDSGAPSNLWGEAILTANSILNKIPHKKCDKTPYEMWKDKTPSYKNMKVWGCLAKVQVPLPKRTIIGPKTVDCVYIGPAENSAAYRFIVHKSDNAEVKVNTIIESNEAEFFEDVFPYKEPRNPCTKRVRDDNDRVRIQEEEYEPRRSKRARVAKDFGTDFMTFLSEYEPQTYKAAMESLEASYWKEAIQSEVESILSNHTWELVDLPPGNKLIGHKWIFTKKLRPDGTIEKYKARLVAKGFRQKEGLDFFDTYSPVTRITSIRFLIAVSAIYDLEIHQMDVKTAFLNGELAR

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JAEFBK010000007
EMBL· GenBank· DDBJ
KAG7585378.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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