A0A8T1PUH5 · A0A8T1PUH5_CARIL
- ProteinS-adenosylmethionine synthase
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids393 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the formation of S-adenosylmethionine from methionine and ATP. The reaction comprises two steps that are both catalyzed by the same enzyme: formation of S-adenosylmethionine (AdoMet) and triphosphate, and subsequent hydrolysis of the triphosphate.
Catalytic activity
- L-methionine + ATP + H2O = S-adenosyl-L-methionine + phosphate + diphosphate
Cofactor
Protein has several cofactor binding sites:
Note: Binds 1 potassium ion per subunit. The potassium ion interacts primarily with the substrate.
Mg2+ (UniProtKB | Rhea| CHEBI:18420 )
Co2+ (UniProtKB | Rhea| CHEBI:48828 )
Note: Binds 2 divalent ions per subunit. The metal ions interact primarily with the substrate. Can utilize magnesium, manganese or cobalt (in vitro).
Pathway
Amino-acid biosynthesis; S-adenosyl-L-methionine biosynthesis; S-adenosyl-L-methionine from L-methionine: step 1/1.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Molecular Function | ATP binding | |
Molecular Function | metal ion binding | |
Molecular Function | methionine adenosyltransferase activity | |
Biological Process | one-carbon metabolic process | |
Biological Process | S-adenosylmethionine biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameS-adenosylmethionine synthase
- EC number
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > fabids > Fagales > Juglandaceae > Carya
Accessions
- Primary accessionA0A8T1PUH5
Proteomes
Subcellular Location
Interaction
Subunit
Homotetramer.
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 4-101 | S-adenosylmethionine synthetase N-terminal | ||||
Sequence: FLFTSESVNEGHPDKLCDQISDAVLDACLEHDPESKVACETCTKTNMVMVFGEITTETNVDYEKIVRDTCRSIGFISNDVGLDADNCKVLVNIEQQSP | ||||||
Domain | 117-238 | S-adenosylmethionine synthetase central | ||||
Sequence: EIGAGDQGHMFGYATDETPELMPLSHVLATKLGARLTDVRKSGTCPWLRPDGKTQVTVEYYNDHGAMVPIRVHTVLISTQHDETVTNDEIAADLKEHVIKPVIPEKYLDEKTIFHLNPSGRF | ||||||
Domain | 240-381 | S-adenosylmethionine synthetase C-terminal | ||||
Sequence: IGGPHGDAGLTGRKIIIDTYGGWGAHGGGAFSGKDPTKVDRSGAYIVRQAAKSIVANGLARRCIVQVSYAIGVPEPLSVFVDTYCTGKIPDKEILKIVKENFDFRPGMISINLDLKRGGNGRFLKTAAYGHFGRDDPDFTWE |
Sequence similarities
Belongs to the AdoMet synthase family.
Family and domain databases
Sequence
- Sequence statusComplete
- Length393
- Mass (Da)43,209
- Last updated2022-10-12 v1
- Checksum9D5560B8292315C2
Computationally mapped potential isoform sequences
There is 1 potential isoform mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A8T1PRM6 | A0A8T1PRM6_CARIL | CIPAW_07G034900 | 398 |
Keywords
- Technical term