A0A8T0UPZ9 · A0A8T0UPZ9_PANVG

Function

function

Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Binds 1 Mg2+ ion per monomer.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site23-28ATP (UniProtKB | ChEBI)
Binding site49a ribonucleoside 5'-phosphate (UniProtKB | ChEBI)
Binding site70-72a ribonucleoside 5'-phosphate (UniProtKB | ChEBI)
Binding site97-100a ribonucleoside 5'-phosphate (UniProtKB | ChEBI)
Binding site104CMP (UniProtKB | ChEBI)
Binding site136ATP (UniProtKB | ChEBI)
Binding site140a ribonucleoside 5'-phosphate (UniProtKB | ChEBI)
Binding site151a ribonucleoside 5'-phosphate (UniProtKB | ChEBI)
Binding site179ATP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Cellular Componentnucleus
Molecular Function(d)CMP kinase activity
Molecular FunctionATP binding
Molecular FunctionUMP kinase activity
Biological Process'de novo' pyrimidine nucleobase biosynthetic process
Biological ProcessCDP biosynthetic process
Biological Processphosphorylation
Biological ProcessUDP biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    UMP-CMP kinase
  • EC number
  • Alternative names
    • Deoxycytidylate kinase
      (CK
      ; dCMP kinase
      )
    • Uridine monophosphate/cytidine monophosphate kinase
      (UMP/CMP kinase
      ; UMP/CMPK
      )

Gene names

    • ORF names
      PVAP13_3KG111200

Organism names

  • Taxonomic identifier
  • Strain
    • AP13
  • Taxonomic lineage
    Eukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > Liliopsida > Poales > Poaceae > PACMAD clade > Panicoideae > Panicodae > Paniceae > Panicinae > Panicum > Panicum sect. Hiantes

Accessions

  • Primary accession
    A0A8T0UPZ9

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Monomer.

Family & Domains

Features

Showing features for region.

TypeIDPosition(s)Description
Region199-231Disordered

Domain

Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.

Sequence similarities

Belongs to the adenylate kinase family. UMP-CMP kinase subfamily.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    231
  • Mass (Da)
    25,619
  • Last updated
    2022-10-12 v1
  • Checksum
    B82861DA79FF45A6
MDEVGSFPPGKKIAVVFVIGGPGSGKGTQCSMIVKQFGFTHLSAGDLLREEAKSDTEQGTMIKNLMREGKLVPSELIVKLLLKAMLQSGNDKFLVDGFPRNEENRQAYESIIKIEPDFVLFIDCPKEELERRILNRNQGRDDDNIDTIRRRFEVFQESTLPVVQYYEKRRKLRRVDGAKSADAVFKDVKAIFTQLNTQNEASATASPHSRPTTAAAGNPSPSSPASSCVLL

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CM029041
EMBL· GenBank· DDBJ
KAG2624188.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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