A0A8T0A3I5 · A0A8T0A3I5_9BILA

Function

function

Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Cofactor

[4Fe-4S] cluster (UniProtKB | Rhea| CHEBI:49883 )

GO annotations

AspectTerm
Cellular Componentmitochondrion
Cellular Componentnucleus
Molecular Function4 iron, 4 sulfur cluster binding
Molecular FunctionDNA binding
Molecular FunctionDNA-(apurinic or apyrimidinic site) endonuclease activity
Molecular Functionendonuclease activity
Molecular Functionlyase activity
Molecular Functionoxidized pyrimidine nucleobase lesion DNA N-glycosylase activity
Biological Processbase-excision repair, AP site formation
Biological Processnucleotide-excision repair

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Endonuclease III homolog
  • EC number
  • Alternative names
    • Bifunctional DNA N-glycosylase/DNA-(apurinic or apyrimidinic site) lyase
      (DNA glycosylase/AP lyase
      )

Gene names

    • Name
      NTH1
    • ORF names
      Mgra_00000841

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • VN-18
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Nematoda > Chromadorea > Rhabditida > Tylenchina > Tylenchomorpha > Tylenchoidea > Meloidogynidae > Meloidogyninae > Meloidogyne

Accessions

  • Primary accession
    A0A8T0A3I5

Proteomes

Subcellular Location

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain81-230HhH-GPD

Sequence similarities

Belongs to the Nth/MutY family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    259
  • Mass (Da)
    29,260
  • Last updated
    2022-10-12 v1
  • MD5 Checksum
    A17C3EC7A4E46E6D0F2609F9671CFF77
MAPKRSTAKILKTNQLNSLSTNEIEDINCSKQNKICQDIKLIKSMRKNADAPVDLMGCQTCADANADPKVFRFQTLVALMLSSQTKDQITSAAMERLRSVNCTISSILNLSNEQLEELLKPVGFYRRKAEYLKRVCAILRDKYNDDIPNTFEGLCELPGVGPKMANLAIKIAFGRIDEGIGVDTHVHRICNRLNWIKTKTAEQTEFELREVLPKDEWSTINQLLVGFGQTICLPVRPKCSECLLNGQCYYSKKINLKKK

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JABEBT010000004
EMBL· GenBank· DDBJ
KAF7639513.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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