A0A8S9ZKH7 · A0A8S9ZKH7_9BILA

Function

function

ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the membrane-bound receptor, and returning it to the cytosol to initiate a new round of targeting.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Features

Showing features for binding site, active site.

1961100200300400500600700800900
Type
IDPosition(s)Description
Binding site606-613ATP (UniProtKB | ChEBI)
Active site635
Binding site856ATP (UniProtKB | ChEBI)
Binding site883ATP (UniProtKB | ChEBI)
Binding site898Zn2+ (UniProtKB | ChEBI); ligand shared between dimeric partners
Binding site901Zn2+ (UniProtKB | ChEBI); ligand shared between dimeric partners

GO annotations

AspectTerm
Cellular ComponentGET complex
Molecular FunctionATP binding
Molecular FunctionATP hydrolysis activity
Molecular Functionhelicase activity
Molecular Functionmetal ion binding
Biological Processpost-translational protein targeting to endoplasmic reticulum membrane
Biological Processprotein insertion into ER membrane

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    ATPase ASNA1 homolog
  • EC number
  • Alternative names
    • Arsenical pump-driving ATPase homolog
    • Arsenite-stimulated ATPase

Gene names

    • ORF names
      Mgra_00006771

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • VN-18
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Nematoda > Chromadorea > Rhabditida > Tylenchina > Tylenchomorpha > Tylenchoidea > Meloidogynidae > Meloidogyninae > Meloidogyne

Accessions

  • Primary accession
    A0A8S9ZKH7

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Homodimer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain5-174Helicase C-terminal

Sequence similarities

Belongs to the arsA ATPase family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    961
  • Mass (Da)
    109,201
  • Last updated
    2022-10-12 v1
  • MD5 Checksum
    878755395A2287BB6157B1AFA943640C
MNCENLCKLLTNMCPSDFREHRSTERSSILTQLRDEHDGKICPILEAGILCGVAYHHSGLVNDERLLIESAYKNGIISIICCTSTLAAGVNLPARRVIIRSPYIGRQLIKKSQYLQMIGRAGRAGLDEKGDCITILKNGNEFSTFKNMLENPLEPCISGLCDDQQREAFFLDLIVLKMCSTIDEIFEVFKNSLFGIQKHDDIELRILTEKTLQSLLGNQMLIQPEVDHFFSTQIGMATFNANFNPQMALDINRDLSENLSQGIVLSSHFHLLYNCVQMDVEVIDLDWNLFHNEYLTLKKEERELLHLMGFSEGTIVQFILYSSNKMNISVKAQRFYVAFMLRQIWEQRPLWEVAQHFDVPRGWLQSVLQSALSQASSIIRFAERTPSLWALRSLLPEMVKRLSECTRQELIPLLSIDCVKAGRARLLYEHGYRTVGSIAKVNAKKLISDLGGKLNLTQAWRMINSAKTIIRDQIAEKAEELEKLGANDVFEFIEPTKIFTQKLNYSSDKATFRPVLNSFGFELEAEDEEEEEEKGKISPIIFHSMLLFIFFYLDLNCSFLIIISCLITKCGVVVKEKMNLEQELLDPTLKNVVEQRSLKWVFVGGKGGVGKTTCSCSLAVQLAKNRRSVLIISTDPAHNISDAFSQKFSKVPSKVNGFDNLYAMEVDGTGLGDGEPPLGPDDGKDIFSAGKKLLAEFAGGLPGIDEATSFSQMIKFMGFAFRFTTFLTKNKKAKFLPEENLKLHTRAVYLTANFPLVQSMDFEIVLFDTAPTGHTLRLLQFPSVIEKGLGKFLSLKSQFLPMFSQITPMFGFNDISMETTSNKLEETLRIVLFHFAIFLDDLLVNLTTFVCVCIAEFLSMYETERLVQELTKQDIDVHNIVVNQLLFPDRNSEGNITCKKCQSRYNIQQKYLEQISELYEDFHITKLPLLDTEVRGPQMIKEFSERLVNDSYPVKLTINFN

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JABEBT010000069
EMBL· GenBank· DDBJ
KAF7633801.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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