A0A8S9XU06 · A0A8S9XU06_APOLU

Function

function

Catalyzes the last step of the cholesterol synthesis pathway, which transforms cholesta-5,7-dien-3beta-ol (7-dehydrocholesterol,7-DHC) into cholesterol by reducing the C7-C8 double bond of its sterol core. Can also metabolize cholesta-5,7,24-trien-3beta-ol (7-dehydrodemosterol, 7-DHD) to desmosterol, which is then metabolized by the Delta24-sterol reductase (DHCR24) to cholesterol. Modulates ferroptosis (a form of regulated cell death driven by iron-dependent lipid peroxidation) through the metabolic breakdown of the anti-ferroptotic metabolites 7-DHC and 7-DHD which, when accumulated, divert the propagation of peroxyl radical-mediated damage from phospholipid components to its sterol core, protecting plasma and mitochondrial membranes from phospholipid autoxidation.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

GO annotations

AspectTerm
Cellular Componentmembrane
Molecular Function7-dehydrocholesterol reductase activity
Molecular Functioncysteine-type peptidase activity
Biological Processbrassinosteroid biosynthetic process
Biological Processcholesterol biosynthetic process
Biological Processproteolysis

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    7-dehydrocholesterol reductase
  • EC number
  • Alternative names
    • Sterol Delta(7)-reductase

Gene names

    • ORF names
      GE061_013035

Organism names

  • Taxonomic identifier
  • Strain
    • 12Hb
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Paraneoptera > Hemiptera > Heteroptera > Panheteroptera > Cimicomorpha > Miridae > Mirini > Apolygus

Accessions

  • Primary accession
    A0A8S9XU06

Proteomes

Subcellular Location

Membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane12-31Helical
Transmembrane51-67Helical
Transmembrane124-141Helical
Transmembrane204-220Helical
Transmembrane241-261Helical
Transmembrane273-292Helical
Transmembrane351-379Helical

Keywords

  • Cellular component

PTM/Processing

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain454-514Cathepsin propeptide inhibitor
Domain541-757Peptidase C1A papain C-terminal

Sequence similarities

Belongs to the ERG4/ERG24 family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    758
  • Mass (Da)
    86,123
  • Last updated
    2022-10-12 v1
  • Checksum
    AD672DCB81409AD9
MAKFYDFIRYHLVPPIFIVLFTALVQIVAQFGRGNTLTWYAISDGIVGDRTSWIVVLTFVFWAYLFLRTPGKTLKGPPSPTGYVPIYRDNGLSYYTTTTVTYLLLDAIFDFELSSYIYDQTPQILGTLSLVALLLCFYLFLSPSDDPKSYEKMPALYVFYRGRNFHPRLLGVDVKQLSICRVGLMAFQILENAYFITYLKANGYSQPVFATFFLHTIYLVKFFGTEDKYFFTIDTTLDRAGYYLCWGSIAWVPCFFTYNSYFMVLHQPRISDSTAWVAIGIGLSAIAIQYLIDHQRHHFRSTGGKCKIWGSEPSFITATFTDHKGDQKNALLLTSGFWGTARHLNYAAEAVYALCVCIPGYGLGFTPFIYFFFLLVFVIHRVARDDEKCRAKYGTYWMKYCETVPYKIIPCVPSTRTFVFTSEDDFIMKAILLLVAVAVTARAVSLEKVVNGEWKLYKLVHSKTYEDEFEDAMRLELFKKSRREILEHNIKYELGLVKYTKGLNQFSDMLPEELAKYNGIIKPSNSSIHGPTFSKPSLVGIKAHVDWNAQGAVTEVKNQGHCGSCWAFASIGALEGQHFLKTKQLIPLSEQNLVDCAKGRRYHNRGCHGGWMNTAFQYIKDNRGVDTEDSYPYEAQDDECRFRKSNVGAKDAGFEQIPPGDEEALKAAVATKGPVAVAIDVKNSFYSYKRGVYFEQMCSPHTPRHAVLVVGYGSEGGEDYWLVKNSWGRGWGDDGFVKMARNRNDHCGIASYASYPLV

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
WIXP02000004
EMBL· GenBank· DDBJ
KAF6212512.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp