A0A8S9VHY6 · A0A8S9VHY6_PLAFO

Function

function

RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs. Catalyzes the formation of N4-acetylcytidine (ac4C) in 18S rRNA. Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis. Catalyzes the formation of ac4C in serine and leucine tRNAs. Requires a tRNA-binding adapter protein for full tRNA acetyltransferase activity but not for 18S rRNA acetylation.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site436-445ATP (UniProtKB | ChEBI)
Binding site612ATP (UniProtKB | ChEBI)
Binding site836-842acetyl-CoA (UniProtKB | ChEBI)
Binding site945acetyl-CoA (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Component90S preribosome
Cellular Componentnucleolus
Molecular FunctionATP binding
Molecular FunctionrRNA cytidine N-acetyltransferase activity
Molecular FunctiontRNA binding
Biological ProcessrRNA acetylation involved in maturation of SSU-rRNA
Biological ProcesstRNA acetylation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    RNA cytidine acetyltransferase
  • EC number
  • Alternative names
    • 18S rRNA cytosine acetyltransferase

Gene names

    • ORF names
      CYL21_3899

Organism names

  • Taxonomic identifier
  • Strain
    • NF54
  • Taxonomic lineage
    Eukaryota > Sar > Alveolata > Apicomplexa > Aconoidasida > Haemosporida > Plasmodiidae > Plasmodium > Plasmodium (Laverania)

Accessions

  • Primary accession
    A0A8S9VHY6

Proteomes

Subcellular Location

Keywords

  • Cellular component

Structure

3D structure databases

Family & Domains

Features

Showing features for domain, region, compositional bias.

TypeIDPosition(s)Description
Domain8-199tRNA(Met) cytidine acetyltransferase TmcA N-terminal
Region238-278Disordered
Compositional bias263-278Polar residues
Domain431-630Helicase
Domain670-746N-acetyltransferase
Domain800-972N-acetyltransferase
Domain1068-1235Possible tRNA binding
Region1249-1269Disordered
Compositional bias1253-1269Basic residues

Sequence similarities

Belongs to the RNA cytidine acetyltransferase family. NAT10 subfamily.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,269
  • Mass (Da)
    149,482
  • Last updated
    2022-10-12 v1
  • Checksum
    84DC905DDDECDF6C
MKKKVDNRIKILIENNIAVGQRSMFFVVGDEGKNVVVNFYFLLNRLINRTHNILWCYKKKLDFSTSKKKRYREMKKKIKKGTFDQTIDNNFDMFLKNADIRFCFYKESKKVLGKTYSICILQDFSYITPNILCRCLETVIGGGLIIFLINKQNELKDLYNLTLNYHKKYTMNGICNVYNNYIHRFFLSLNKCENAMFIDDEMNILPLNENYLKIKKITSKGSDGNGIGNNVTKLKHMEVQKEGEQSGSNINNNDDDDNDDNDNYSNSNNYSNSNSNNYSHTKSATLGGFLCPDKNLLQEKLKFLESICEENEKKKEEEKIFLYSSKFSRNDTCTKINKNGDIHSSDNKYTRDTYETYDSVTNTSTTANTYNNYISKKTKKKDVYSFLDRNIMNLLNICLSLDQLEVLLNMCKILRNDEEKKKNIKEVLFNLLANRGRGKSATLGLLLSLSIYFNYSNIIICSGNNEGVQTIYDFLDKGLHILGFNEFKDYEKIYDMGKIKEIVIFKNMKYLKQRIRFFDIIEEDILNSELMIIDEAACIPIDILKKKIKGEITILSTTLNGYEGTGKTFTFKLLKQLKKKFITQLSYEEFKNMNFLYFDKAYIDLTLTNPIRYSYNDQVEKWLNDFLCLNCNEPTNIKDNICSPSNCELYFVNKNIFKNYNRTSEILLKKIMTLFITSHYKNTPNDIIMILDSQQHHLFILINKNNNHYNNNNILEDQIDELDIYGVLHCAIDGIINNGNVKKTVKLEDIIHLVKNNNTQKENPTLDTKEINDSNDQKLEKKENINQINSDNHKELLINEYEGNLIPYIISDYFNYYFYNYIGIRIVRISIHPSMQNLNYGSEFLKKVCNYYNEYNSKQRHDNNTKQKIKINNNDSNNCGDSNNCGDSNNCDDSNNCDDNVKYSENIILFNCNGKNIYFDKKLKQIDYIGTCFGLTKGLLIFWQKNKFIPVFLKQQKNEITGEFSVLMLKDLNEDLKHIIANFYTDFVRSVTKLLPYSFKYMESFIVFNLLHNNNYSIPLKQDDAPTIVKDHNNTDHTYNHNGHIKNNLHNNHFYYDNYEDQHLSFYNNNLINQQTIFYFFHTNDICRLKRFVLEGRNFYEILYLLSTIANLILFKKVKIDLSFLEYTILYAVAFQKKTPKEISDEIKINVNQTNAIFRKIIHRFYNYIKDIMEKQIEKEVNAELNEKLKVKKKRSLNIELPSEEYKDELERNSLIVKKKLKKEKLSLMKEFNLEGDIKRKEINIKTNDNLEIKKKKKKKKKKKKQETN

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias263-278Polar residues
Compositional bias1253-1269Basic residues

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
QFXU01000017
EMBL· GenBank· DDBJ
KAF4328160.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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