A0A8S3Z973 · A0A8S3Z973_9EUPU

  • Protein
    Peroxisomal bifunctional enzyme
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    5/5

Function

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

  • (2E)-hexadecenedioyl-CoA + H2O = (3S)-hydroxyhexadecanedioyl-CoA
    This reaction proceeds in the forward direction.
  • (2S,3S)-3-hydroxy-2-methylbutanoyl-CoA = (2E)-2-methylbut-2-enoyl-CoA + H2O
    This reaction proceeds in the backward direction.
  • (3E)-decenoyl-CoA = (2E)-decenoyl-CoA
    This reaction proceeds in the forward direction.
  • (3E)-hexenoyl-CoA = (2E)-hexenoyl-CoA
    This reaction proceeds in the forward direction.
  • (3E,5Z)-octadienoyl-CoA = (2E,5Z)-octadienoyl-CoA
    This reaction proceeds in the backward direction.
  • (3E,5Z)-tetradecadienoyl-CoA = (2E,5Z)-tetradecadienoyl-CoA
    This reaction proceeds in the backward direction.
  • (3S)-hydroxydecanoyl-CoA + NAD+ = 3-oxodecanoyl-CoA + H+ + NADH
    This reaction proceeds in the forward direction.
  • (3S)-hydroxydecanoyl-CoA = (2E)-decenoyl-CoA + H2O
    This reaction proceeds in the backward direction.
  • (3S)-hydroxyhexadecanedioyl-CoA + NAD+ = 3-oxohexadecanedioyl-CoA + H+ + NADH
    This reaction proceeds in the forward direction.
  • (3S)-hydroxyhexadecanoyl-CoA + NAD+ = 3-oxohexadecanoyl-CoA + H+ + NADH
    This reaction proceeds in the forward direction.
  • (3S)-hydroxyhexadecanoyl-CoA = (2E)-hexadecenoyl-CoA + H2O
    This reaction proceeds in the backward direction.
  • (3S)-hydroxyhexanoyl-CoA = (2E)-hexenoyl-CoA + H2O
    This reaction proceeds in the backward direction.
  • (3Z)-hexenoyl-CoA = (2E)-hexenoyl-CoA
    This reaction proceeds in the forward direction.
  • a (3E)-enoyl-CoA = a 4-saturated (2E)-enoyl-CoA
    This reaction proceeds in the forward direction.
    EC:5.3.3.8 (UniProtKB | ENZYME | Rhea)
  • a (3S)-3-hydroxyacyl-CoA + NAD+ = a 3-oxoacyl-CoA + H+ + NADH
    This reaction proceeds in the forward direction.
    EC:1.1.1.35 (UniProtKB | ENZYME | Rhea)
  • a (3Z)-enoyl-CoA = a 4-saturated (2E)-enoyl-CoA
    This reaction proceeds in the forward direction.
    EC:5.3.3.8 (UniProtKB | ENZYME | Rhea)
  • a 4-saturated-(3S)-3-hydroxyacyl-CoA = a (3E)-enoyl-CoA + H2O
    This reaction proceeds in the forward direction.
    EC:4.2.1.17 (UniProtKB | ENZYME | Rhea)

Pathway

Lipid metabolism; fatty acid beta-oxidation.

GO annotations

AspectTerm
Cellular Componentperoxisome
Molecular Function3-hydroxyacyl-CoA dehydrogenase activity
Molecular FunctionNAD+ binding
Biological Processfatty acid beta-oxidation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Peroxisomal bifunctional enzyme
  • EC number
  • Alternative names
    • Multifunctional enzyme 1

Gene names

    • ORF names
      CUNI_LOCUS11287

Organism names

  • Taxonomic identifier
  • Organism
  • Taxonomic lineage
    Eukaryota > Metazoa > Spiralia > Lophotrochozoa > Mollusca > Gastropoda > Heterobranchia > Euthyneura > Panpulmonata > Eupulmonata > Stylommatophora > Helicina > Helicoidea > Geomitridae > Candidula

Accessions

  • Primary accession
    A0A8S3Z973

Proteomes

Subcellular Location

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain297-4753-hydroxyacyl-CoA dehydrogenase NAD binding
Domain478-5813-hydroxyacyl-CoA dehydrogenase C-terminal
Domain618-7033-hydroxyacyl-CoA dehydrogenase C-terminal

Sequence similarities

Belongs to the enoyl-CoA hydratase/isomerase family.
In the C-terminal section; belongs to the 3-hydroxyacyl-CoA dehydrogenase family.
In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    720
  • Mass (Da)
    79,411
  • Last updated
    2022-10-12 v1
  • Checksum
    704378D5E916A1F6
MVDYIVDGNIAVLEINNPPVNALSIHVREGLLTGIQKANQDGSVQAIVIIGKGSTFPSGADIREFGKPPKEPWLTAVGEAIEASEKPVISALHGTALGGGLEVALFSHYRIADERSRVGFPEVKLGLLPGAQGTIRLPRLTGLAVAMRIITSGDHINAPEALKYGILDKLISGNLLQEAKTFAKSVIGKPLDNRRLSKIAVRDAATVDKHFDEALAEVKRKYKGMIAPVNCLKSIRGSAKLPFVEAARLEAALFRELLTSAQSAALRYSFFADRSAPRWKLPSGASIENTKPDIIKSVAVIGAGTMGSAIAICFIRVGIPVLLVEQNDKLLQNALKNIGQILQGSVKLNRITADQRKQSLQILRGETSLDIVSDVDLVVEAVFENLKLKQEIFARLDKICKPSALLCSNTSTLDIDKIAVATNRPGKVAGMHFFAPAHIMKLLENVYGTHTSPSTVATIMDIGKRIGKVSVLVRTCDGFVANRMNRMVGNEAVFMLEEGALPQDVDRVLEDFGMAMGPFRVTDLSGSDVGWRIRQERAKEQGIQLTYETRFVNGERYSSLPDRLYELGRYGQKTGKGWYRYEKPFARTAYPDPEITDVINSHCRSLGIERRVIPPQEIIERCLFAAINEGFKVLEEGVAEKPENIDIIWQYGLGFPRYRGGPMFYASQVGLKTIYERVCYYYDAFPHSSYWAPSDLLRKLASHSTEVPIDQWTSKERSRL

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CAJHNH020002146
EMBL· GenBank· DDBJ
CAG5125729.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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