A0A8S1BYH7 · A0A8S1BYH7_9INSE
- ProteinPresenilin
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids488 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
function
Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namePresenilin
- EC number
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Palaeoptera > Ephemeroptera > Pisciforma > Baetidae > Cloeon
Accessions
- Primary accessionA0A8S1BYH7
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Endoplasmic reticulum membrane ; Multi-pass membrane protein
Golgi apparatus membrane ; Multi-pass membrane protein
Membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 104-125 | Helical | ||||
Sequence: LFVPVSLCMLVVVATISSISFY | ||||||
Transmembrane | 151-173 | Helical | ||||
Sequence: ALANAGILLIVIVIMTFILILLY | ||||||
Transmembrane | 180-201 | Helical | ||||
Sequence: VIHGWLILSSLMLLFVFAYLYL | ||||||
Transmembrane | 213-232 | Helical | ||||
Sequence: DYFTLAVIMWNVGVVGMICI | ||||||
Transmembrane | 244-260 | Helical | ||||
Sequence: YLIFIAALMALVFIKYL | ||||||
Transmembrane | 266-282 | Helical | ||||
Sequence: WVVLAVISIWDLVAVLT | ||||||
Transmembrane | 427-449 | Helical | ||||
Sequence: MTLACFIAILIGLCLTLLLLAII | ||||||
Transmembrane | 455-474 | Helical | ||||
Sequence: ALPISITFGLIFYFSTREIV |
Keywords
- Cellular component
Interaction
Subunit
Homodimer.
Structure
Family & Domains
Features
Showing features for compositional bias, region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 1-15 | Polar residues | ||||
Sequence: MSANQSGSEHTALMD | ||||||
Region | 1-85 | Disordered | ||||
Sequence: MSANQSGSEHTALMDAVVQQSEPPNYGTDRQTRQRPNKRTRSSVPVQGTGNPSRDDPSPPTVSRSPGQYDDRARLNDGTGPSGQE | ||||||
Compositional bias | 38-65 | Polar residues | ||||
Sequence: KRTRSSVPVQGTGNPSRDDPSPPTVSRS | ||||||
Region | 322-354 | Disordered | ||||
Sequence: GGETTGDETRPAARQAQRQERGQSGAGDDNGGF | ||||||
Compositional bias | 331-345 | Polar residues | ||||
Sequence: RPAARQAQRQERGQS |
Domain
The PAL motif is required for normal active site conformation.
Sequence similarities
Belongs to the peptidase A22A family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length488
- Mass (Da)54,284
- Last updated2022-10-12 v1
- ChecksumC69CD4608E9FEEEB
Computationally mapped potential isoform sequences
There is 1 potential isoform mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A8S1BY60 | A0A8S1BY60_9INSE | CLODIP_2_CD01790 | 475 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 1-15 | Polar residues | ||||
Sequence: MSANQSGSEHTALMD | ||||||
Compositional bias | 38-65 | Polar residues | ||||
Sequence: KRTRSSVPVQGTGNPSRDDPSPPTVSRS | ||||||
Compositional bias | 331-345 | Polar residues | ||||
Sequence: RPAARQAQRQERGQS |
Keywords
- Technical term