A0A8S1BUC2 · A0A8S1BUC2_9INSE
- ProteinDihydroorotase
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids2177 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
Catalytic activity
- (S)-dihydroorotate + H2O = H+ + N-carbamoyl-L-aspartate
Cofactor
Pathway
Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 1/3.
Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 2/3.
Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 3/3.
Features
Showing features for active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Active site | 252 | Nucleophile | ||||
Sequence: C | ||||||
Active site | 336 | |||||
Sequence: H | ||||||
Active site | 338 | |||||
Sequence: E |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Molecular Function | amino acid binding | |
Molecular Function | aspartate carbamoyltransferase activity | |
Molecular Function | ATP binding | |
Molecular Function | carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity | |
Molecular Function | dihydroorotase activity | |
Molecular Function | metal ion binding | |
Biological Process | 'de novo' pyrimidine nucleobase biosynthetic process | |
Biological Process | citrulline biosynthetic process | |
Biological Process | glutamine metabolic process | |
Biological Process | UTP biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended nameDihydroorotase
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Palaeoptera > Ephemeroptera > Pisciforma > Baetidae > Cloeon
Accessions
- Primary accessionA0A8S1BUC2
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 516-708 | ATP-grasp | ||||
Sequence: AQKMASIGEKVSPSLSVVSMEEALEAGRKLGYPVLARSAYTLGGLGSGFANDENELIALAQQAFAHSKKLIIDKSLKGWKEVEYEVVRDAFDNCITVCNMENLDPLGIHTGESIVVAPSQTLNNREYHKLRSVAIKVIRSLGIIGECNIQYALSPHSDQYYIIEVNARLSRSSALASKATGYPLAYVAAKLCL | ||||||
Domain | 1047-1238 | ATP-grasp | ||||
Sequence: SRMLDRIGILQPRWRELTTLESSIEFCETVGFPCLIRPSYVLSGAAMNVAHNENDLKTYLQTAAKVSKEHPVVVSKFLLEAKEIDVDAVAKDGEILCMAVSEHVENAGVHSGDATLMTPPQDINSTTLKKISAIARAIADNLEVTGPFNMQLIAKDDELKVIECNVRVSRSFPFVSKTLEHDFVAVATRVML | ||||||
Domain | 1303-1458 | MGS-like | ||||
Sequence: FQLPKKCILLSIGTYKHKSELLLSIKNLSKMGFKLFASDGTAEFCNENGIKVTPVDWSFEDIGENSTCGKLNEMADFLANRKFDLVINLPKRDGGARRVSNLMTRGYRTRRMAVDYSIPLITNVKCAKLLIDALKKVGGAPLMKPHTDCLSMHQVM |
Sequence similarities
In the 2nd section; belongs to the CarB family.
In the 3rd section; belongs to the metallo-dependent hydrolases superfamily. DHOase family. CAD subfamily.
In the C-terminal section; belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
In the N-terminal section; belongs to the CarA family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length2,177
- Mass (Da)240,475
- Last updated2022-10-12 v1
- Checksum87535BF59D7A635F
Computationally mapped potential isoform sequences
There are 5 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A8S1BQU0 | A0A8S1BQU0_9INSE | CLODIP_2_CD05144 | 2183 | ||
A0A8S1BKJ1 | A0A8S1BKJ1_9INSE | CLODIP_2_CD05144 | 1997 | ||
A0A8S1BX64 | A0A8S1BX64_9INSE | CLODIP_2_CD05144 | 2095 | ||
A0A8S1BU61 | A0A8S1BU61_9INSE | CLODIP_2_CD05144 | 2034 | ||
A0A8S1BJS0 | A0A8S1BJS0_9INSE | CLODIP_2_CD05144 | 2101 |
Keywords
- Technical term