A0A8S1BUC2 · A0A8S1BUC2_9INSE

  • Protein
    Dihydroorotase
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    4/5

Function

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Pathway

Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 1/3.
Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 2/3.
Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 3/3.

Features

Showing features for active site.

TypeIDPosition(s)Description
Active site252Nucleophile
Active site336
Active site338

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Functionamino acid binding
Molecular Functionaspartate carbamoyltransferase activity
Molecular FunctionATP binding
Molecular Functioncarbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
Molecular Functiondihydroorotase activity
Molecular Functionmetal ion binding
Biological Process'de novo' pyrimidine nucleobase biosynthetic process
Biological Processcitrulline biosynthetic process
Biological Processglutamine metabolic process
Biological ProcessUTP biosynthetic process

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Dihydroorotase

Gene names

    • ORF names
      CLODIP_2_CD05144

Organism names

  • Taxonomic identifier
  • Organism
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Palaeoptera > Ephemeroptera > Pisciforma > Baetidae > Cloeon

Accessions

  • Primary accession
    A0A8S1BUC2

Proteomes

Subcellular Location

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain516-708ATP-grasp
Domain1047-1238ATP-grasp
Domain1303-1458MGS-like

Sequence similarities

In the 2nd section; belongs to the CarB family.
In the 3rd section; belongs to the metallo-dependent hydrolases superfamily. DHOase family. CAD subfamily.
In the C-terminal section; belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
In the N-terminal section; belongs to the CarA family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    2,177
  • Mass (Da)
    240,475
  • Last updated
    2022-10-12 v1
  • Checksum
    87535BF59D7A635F
MQSMAKLVLSFPPYIFVALTLWPVFQTGMVGYVEALTDPSYHGQFLLLTYPLIGNYGVPEDTKDELGLSRWFESDKIHAKALIVSEKCDKPSHFQSVKSIDKWLEENDVTGLCGVDTRALTRILRETGSTLARIVLGEPSSDDMVREIPDLNLHNLVDEVSPKDAVVVYNKGGTPKIRLMHCGAKTNQIRCLIKRGAQVEVVPWDHPLLEEQDKFDALFLSNGPGDPALCSTLVENLKKLMEAVVKPIFGICLGHQILAIAAGFTTYKMKYGNRGHNLPCVHLSTGRCFMTTQNHGFAVADNDIPEHWSALFVNKNDGSNEGIVHNKLPYFSVQFHPEHCGGPEDLECLFDVFLKVAQNYLSSPASFTSVNAYLNEQFSYVRADSTEKIIRKVLLLGSGGLSIGQAGEFDYSGSQALKALRENGIISVLINPNIATVQTSRGLADKVYFLPITPEYVEQVIQYERPDGILLTFGGQTALNCGVTLEEKGVLKKYNVEVLGTPISAITITEDREYFAQKMASIGEKVSPSLSVVSMEEALEAGRKLGYPVLARSAYTLGGLGSGFANDENELIALAQQAFAHSKKLIIDKSLKGWKEVEYEVVRDAFDNCITVCNMENLDPLGIHTGESIVVAPSQTLNNREYHKLRSVAIKVIRSLGIIGECNIQYALSPHSDQYYIIEVNARLSRSSALASKATGYPLAYVAAKLCLGKPLTEIKNSVTGVTTACFEPSLDYCVVKIPRWDLSKFSRVSTKIGSSMKSVGEVMAVGRNFEEAFQKALRMTDENVLGFDPYFKPASEKELSEPTDKRMFVLAAAIKEGLSLETLNALTNIDPWFLHKMQAIIALQNELEQSTELTVPLLTRAKKMGFSDKQIASFVSSTELNIRQKRSQVSGPWVKQIDTVSAEFPASTNYLYLTYDGSSHDLDFPGNYVMVIGSGVYRIGSSVEFDWCAVGCLRELKRLGKKTIMLNYNPETVSTDYDMSDRLYFDEISFEVAMDVYQLEDPEGIILSMGGQLPNNIAMDLFRQQARVLGTSPEMVDNAENRFKFSRMLDRIGILQPRWRELTTLESSIEFCETVGFPCLIRPSYVLSGAAMNVAHNENDLKTYLQTAAKVSKEHPVVVSKFLLEAKEIDVDAVAKDGEILCMAVSEHVENAGVHSGDATLMTPPQDINSTTLKKISAIARAIADNLEVTGPFNMQLIAKDDELKVIECNVRVSRSFPFVSKTLEHDFVAVATRVMLGYVEKPVDVLSGCKKVGVKVPQFSFSRLTGADVMLGVEMASTGEVACFGENRYEAYLKALMSTGFQLPKKCILLSIGTYKHKSELLLSIKNLSKMGFKLFASDGTAEFCNENGIKVTPVDWSFEDIGENSTCGKLNEMADFLANRKFDLVINLPKRDGGARRVSNLMTRGYRTRRMAVDYSIPLITNVKCAKLLIDALKKVGGAPLMKPHTDCLSMHQVMRLPGMIDVHVHLREPGATHKEDFETGTSAALAGGVTMICAMPNTNPALTDVTALNYISELASQKAKCDYALFAGASEENTDSVSLLASKVAGLKMYMNDTFTTLKLDDFEVCSQHMKNWPNHLPLCVHAEGATLSTALLLASWNKRPLHVCHVARKQEILAIKKAKEMGMQVTCEVSPHHLFISSEDMDVQSPLSKVKPPICTRDDVQALWDNLSVIDVFATDHAPHLISEKMEHGVPGFPGLETALPLLLNAVNEGKLSMADILSRFHTNPKRIFNLPDQPDTFIEVDMTQTMTVPSMPAYSKAGWTPFAGRTLKGVVHRVVLRGEVAYLEGKVLVGAGFGQDVRKWPAQLPVPSVSLVPTVDNSFTPPIPPPIPPPQEQPKHRIDMQARVMKELNIKPADETIPQLEHAHRTQIMHVLSSRMFSKEQLNRIFDVAETFKIAVQKERSIDHILKGKVLASAFFEVSTRTSSSFSAAMWRLGGSVIHIDEASSSAQKGESLEDSMQVMAGYADVIVLRHPRPGAVDSAAACCRKPVINAGDGTGEHPTQALLDIFSIRHEIGTVNGLTITLVGDLKHGRTVHSLAKLLTLYKVTLRYVAPPGLEMPQEVQDVVAGAGIKQECHTDLESVLPDTDVLYMTRIQRERFTSKVDYEAALGVYRVTPQLMRLAKRKMVVLHPLPRLQEIATEFDTDPRAAYFRQAEHGLYVRMALLAMVLGRC

Computationally mapped potential isoform sequences

There are 5 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A8S1BQU0A0A8S1BQU0_9INSECLODIP_2_CD051442183
A0A8S1BKJ1A0A8S1BKJ1_9INSECLODIP_2_CD051441997
A0A8S1BX64A0A8S1BX64_9INSECLODIP_2_CD051442095
A0A8S1BU61A0A8S1BU61_9INSECLODIP_2_CD051442034
A0A8S1BJS0A0A8S1BJS0_9INSECLODIP_2_CD051442101

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CADEPI010000001
EMBL· GenBank· DDBJ
CAB3359447.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp