A0A8S0H5Q7 · A0A8S0H5Q7_9PSED
- ProteinThiol:disulfide interchange protein DsbD
- GenedsbD2
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids583 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps.
Catalytic activity
- [protein]-dithiol + NAD+ = [protein]-disulfide + H+ + NADH
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | plasma membrane | |
Molecular Function | electron transfer activity | |
Molecular Function | protein-disulfide reductase (NAD(P)H) activity | |
Biological Process | cytochrome complex assembly |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameThiol:disulfide interchange protein DsbD
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Gammaproteobacteria > Pseudomonadales > Pseudomonadaceae > Pseudomonas
Accessions
- Primary accessionA0A8S0H5Q7
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Cell inner membrane ; Multi-pass membrane protein
Membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 209-233 | Helical | ||||
Sequence: LALASSYVLCMALVYAGMGVIAALL | ||||||
Transmembrane | 245-265 | Helical | ||||
Sequence: WVLGSFAALFVLLSLPMFGFF | ||||||
Transmembrane | 286-319 | Helical | ||||
Sequence: GGSLIGCGILGALSALLVGPCMTAPLAGGLLYIA | ||||||
Transmembrane | 325-349 | Helical | ||||
Sequence: LFGGLALFALGLGIGLPLLLLVTLG | ||||||
Transmembrane | 361-379 | Helical | ||||
Sequence: NLLKGVFGILFLGTAIYML | ||||||
Transmembrane | 385-404 | Helical | ||||
Sequence: PGLWMGLWGALALVVAYCAW | ||||||
Transmembrane | 416-437 | Helical | ||||
Sequence: LFGAGALLFAAWGGMLLVGAAG |
Keywords
- Cellular component
PTM/Processing
Features
Showing features for signal, chain, disulfide bond.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-18 | |||||
Sequence: MRRLFLLLFMLFTTLAHA | ||||||
Chain | PRO_5035980044 | 19-583 | Thiol:disulfide interchange protein DsbD | |||
Sequence: GNNPFEVKPDFLPVGKAFVFTSERLPSGETQLFWQIADGYYLYQKRLKFDGVAPELQPTLPAGEDHSDEFFGQQTVYRQGLEVKLPAAASGKVKLGWQGCADAGLCYPPQTLEVDLGGAPAVAASNVAPTSNGSAQDQLLANDLQHKSWGLGLLAFFGFGLLLAFAPCSLPMLPILAGMVVGSGASPRRGLALASSYVLCMALVYAGMGVIAALLGSNLQAWLQQPWVLGSFAALFVLLSLPMFGFFELQMPALLRDRLEGASRQRQGGSLIGCGILGALSALLVGPCMTAPLAGGLLYIAQTGNALFGGLALFALGLGIGLPLLLLVTLGNRFLPKPGPWMNLLKGVFGILFLGTAIYMLRPVLNPGLWMGLWGALALVVAYCAWQQRAIAGRLLHLFGAGALLFAAWGGMLLVGAAGGGDDLWRPLKVYSGGPVANSVTAHDAFTTVKSPAELQGALDSARAQGQWVLLDYYADWCVSCKIMEKTVFGQPQVLEALKDVRLLRLDVTLDNADGRELLSRYKVPGPPSMLWIGPDGSERRSQRITGEVDANAFLQRWTQTREAR | ||||||
Disulfide bond | 118↔124 | Redox-active | ||||
Sequence: CADAGLC | ||||||
Disulfide bond | 496↔499 | Redox-active | ||||
Sequence: CVSC |
Keywords
- PTM
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 458-581 | Thioredoxin | ||||
Sequence: VTAHDAFTTVKSPAELQGALDSARAQGQWVLLDYYADWCVSCKIMEKTVFGQPQVLEALKDVRLLRLDVTLDNADGRELLSRYKVPGPPSMLWIGPDGSERRSQRITGEVDANAFLQRWTQTRE |
Sequence similarities
Belongs to the thioredoxin family. DsbD subfamily.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Sequence processingThe displayed sequence is further processed into a mature form.
- Length583
- Mass (Da)62,442
- Last updated2022-10-12 v1
- Checksum7785A4564F78E96F
Keywords
- Technical term