A0A8S0H0S6 · A0A8S0H0S6_9PSED
- ProteinDeferrochelatase
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids436 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Involved in the recovery of exogenous heme iron. Extracts iron from heme while preserving the protoporphyrin ring intact.
Catalytic activity
- 2 H+ + heme b = Fe2+ + protoporphyrin IXThis reaction proceeds in the forward direction.
Cofactor
Note: Binds 1 heme b (iron(II)-protoporphyrin IX) group non-covalently per subunit.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Cellular Component | periplasmic space | |
Molecular Function | heme binding | |
Molecular Function | lyase activity | |
Molecular Function | metal ion binding | |
Molecular Function | peroxidase activity | |
Biological Process | iron import into cell |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameDeferrochelatase
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Gammaproteobacteria > Pseudomonadales > Pseudomonadaceae > Pseudomonas
Accessions
- Primary accessionA0A8S0H0S6
Proteomes
Subcellular Location
PTM/Processing
Features
Showing features for signal, chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-40 | |||||
Sequence: MNDSDQPNPSFSAQRRRVLLGMGAAGVALAGSSLSCPAMA | ||||||
Chain | PRO_5035960652 | 41-436 | Deferrochelatase | |||
Sequence: AAPAQVTEAPSSDKTQDRHDFHGQHQSGIVTPRPAAGMLVSFDVLASDRDDLERLFRTLDQRIAFLMRGGPVAQVDPKLPPLDSGILGPVVTPDNLTITVSVGESLFDERFGLEAAKPKRLIRMVGFPNDALEPACCHGDLSLQFCSNTADTNIHALRDIVKNLPDLLLVRWKQEGSVPPQAPAKPGEPAQSARNFLGFRDGSANPDSNDPKAMQQIVWVQPGSDEPAWAAHGSYQAVRIIRNFVERWDRTPLQEQESIIGRIKTSGAPMDGQKESQVPDYARDPHGKVTKLDAHIRLANPRTAQSQQNLILRRPFNYSNGVNKNGQLDMGLLFICYQADLEKGFIAVQTRLNGEPLEEYLKPTGGGYFFTLPGVTGEEDFIGRSLLDATRPKSTA |
Interaction
Subunit
Homodimer. Part of a ferrous iron transporter composed of EfeU, EfeO and EfeB.
Family & Domains
Features
Showing features for region, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 45-70 | Disordered | ||||
Sequence: QVTEAPSSDKTQDRHDFHGQHQSGIV | ||||||
Domain | 66-216 | Dyp-type peroxidase N-terminal | ||||
Sequence: QSGIVTPRPAAGMLVSFDVLASDRDDLERLFRTLDQRIAFLMRGGPVAQVDPKLPPLDSGILGPVVTPDNLTITVSVGESLFDERFGLEAAKPKRLIRMVGFPNDALEPACCHGDLSLQFCSNTADTNIHALRDIVKNLPDLLLVRWKQEG | ||||||
Region | 217-250 | Disordered | ||||
Sequence: SVPPQAPAKPGEPAQSARNFLGFRDGSANPDSND | ||||||
Domain | 233-415 | Dyp-type peroxidase C-terminal | ||||
Sequence: ARNFLGFRDGSANPDSNDPKAMQQIVWVQPGSDEPAWAAHGSYQAVRIIRNFVERWDRTPLQEQESIIGRIKTSGAPMDGQKESQVPDYARDPHGKVTKLDAHIRLANPRTAQSQQNLILRRPFNYSNGVNKNGQLDMGLLFICYQADLEKGFIAVQTRLNGEPLEEYLKPTGGGYFFTLPGV | ||||||
Region | 305-324 | Disordered | ||||
Sequence: TSGAPMDGQKESQVPDYARD |
Sequence similarities
Belongs to the DyP-type peroxidase family. EfeB subfamily.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length436
- Mass (Da)47,508
- Last updated2022-10-12 v1
- Checksum154514C4DA26C38F
Keywords
- Technical term